Sentences with phrase «other mechanisms of resistance»

Using tumor biopsies from BRAF melanoma patients treated with either BRAF inhibitors or with combined BRAF and MEK inhibitors, a recently FDA - approved drug combination to fight the other mechanisms of resistance, the researchers found that tumors resistant to the BRAF inhibitors had increased levels of autophagy compared with baseline tumors.

Not exact matches

«Indeed, we believe AR - V7 and other, related variants are a mechanism of resistance in this disease and patients who have them may have a poorer prognosis.»

Adult drug resistant cancer cells may contribute to this problem, and the authors discuss these and other cancer drug resistance mechanisms in their recent publication in the September issue of the journal Cancers.

Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.

«Knowing how these bacteria protect themselves, what the mechanisms of self - resistance of the bacteria are, is important because they could transfer that resistance to other bacteria,» said Tingting Huang, a research associate in the Shen laboratory who was first author of the study with Ryan M. Peterson of the University of Wisconsin, Madison.

The study also may have broader implications for how clinicians approach the development of such treatments and understand mechanisms behind resistance to treatment in other cancers.

Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»

Drs. Baughn and Minato hope that the understanding of mechanisms for synergy will lead them and others to more potent drug combinations that can be deployed in the fight against pathogenic microbes as drug resistance becomes increasingly commonplace.

First of all, it seems that biodiversity may not offer as much protection if the event in question is very extreme: buffering mechanisms which drive ecosystem resistance, such as compensation by better - adapted species or species taking over the functional role of others (functional redundancy), may simply be overwhelmed in such cases.

p53 on the other hand is an anti-cancer gene that normally reduces life span whilst lowering the risk of cancer - the traditional view being that mechanisms of extended longevity and mechanisms of cancer resistance have evolved to a point of balance.

Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.

However, the mechanism of resistance in prostate cancer, and to PARPi other than olaparib, is unknown.

The role of gene regulation in C. auris drug resistance mechanisms and host interactions — such as overexpression of ERG11 and other known fluconazole resistance genes — are currently unknown.

Interpretation: The exo - E415G SNP and plasmepsin 2 - 3 amplification are markers of piperaquine resistance and dihydroartemisinin - piperaquine failures in Cambodia, and can help monitor the spread of these phenotypes into other countries of the Greater Mekong subregion, and elucidate the mechanism of piperaquine resistance.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

Dr. Fiona is also experienced in treating a wide variety of other conditions and has a particular interest in inflammatory disorders, disorders of insulin resistance, and the complex mechanisms of the hormonal system — and in particular, in the connection between the endocrine and immune systems (immuno - endocrinology).