Depletion of Kap104p resulted in a rapid shift of Nab2p from the nucleus to the cytoplasm without affecting the localization of
other nuclear proteins tested.
Not exact matches
The study, «The
nuclear transport receptor Importin - 11 is a tumor suppressor that maintains PTEN
protein,» which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin - 11 may destabilize PTEN, leading to the development of lung, prostate, and
other cancers.
A more generalized version of the technique,
nuclear magnetic resonance (NMR), also offers enormous benefits, enabling scientists to characterize the chemical compositions of materials as well as the structures of
proteins and
other important biomolecules without having to penetrate the objects under study physically.
The
protein binds to RNA in the nucleus to form «small
nuclear ribonucleoproteins,» which help splice the messenger RNA of many
other genes, in preparation for
nuclear export and transcription.
Known key pathological mechanisms are related to defects in structural
proteins,
nuclear proteins, intermediate filaments and
other cyoskeletal
proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.
However, using a new technique known as sensitivity - enhanced
nuclear magnetic resonance (NMR), Whitehead Institute and MIT researchers have shown that they can analyze the structure that a yeast
protein forms as it interacts with
other proteins in a cell.
Other types of RNA play important roles in regulating gene expression (microRNAs), RNA processing by the spliceosome (small
nuclear RNAs or snRNA), and
protein translation (tRNAs).
Naringenin, a chemical found in grapefruit and in
other citrus fruits, activates
proteins called
nuclear receptors that cause the liver to break down fatty acids, study researchers from Hebrew University of Jerusalem and Massachusetts General Hospital in Boston said in a statement.