Not exact matches
Habit then uses blood samples and DNA from a cheek swab to glean details on glucose levels and
obesity - related
genes, among
other factors that could affect metabolism.
However, in the modern time of plenty, their
genes are a liability, leading to high rates of
obesity and diabetes compared with
other races.
«In the current study, we analyzed dozens of variants of those
genes and
other genes frequently associated with
obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to
obesity and ate the most saturated fat had the highest BMIs.»
The CREBRF variant appears to be rare in
other populations, but studying how the
gene works may help researchers better understand
obesity.
George Bray, who heads the clinical
obesity and metabolism department at Louisiana State University, says environment and behavior — like lack of access to exercise facilities and overeating — so strongly affect
gene activity that you can not focus on one while ignoring the
other.
«So that highlights that there are going to be several
genes involved with
obesity, and they're going to interact with each
other in complicated ways.
The researchers note that while some
genes involved in
obesity could already have been implicated in
other aspects of human health,
others could be part of pathways that are not yet understood.
In
other research, a knockout of the
gene that encodes one type of lncRNA in mice conferred some resistance to
obesity caused by a high - fat diet.
Working in mice that were put on high - fat diets to model diabetes, «we demonstrated that
obesity increases the expression of pro-inflammatory
genes in abdominal fat, but not in
other organs such as the liver or muscle, nor in subcutaneous fat,» says Jongsoon Lee, PhD, Assistant Investigator in Joslin's Section on Pathophysiology and Molecular Pharmacology and Assistant Professor of Medicine at Harvard Medical School.
Viewed this way, humans can be considered to have lost two
genes — one affecting uricase and the
other affecting the ability to produce vitamin C — whose absence helped our ancestors during famine but, in today's world, may be increasing our risk for
obesity and diabetes.
In a study published January in the journal Molecular Biology and Evolution, Gibbs and his team compared the DNA of the fat fruit flies to a control group in the lab and found nearly 400 candidate
genes potentially associated with
obesity and
other health problems.
The researchers, mathematician Cristian Tomasetti and cancer geneticist Bert Vogelstein, both of Johns Hopkins University, set out to determine what proportion of cancer mutations are due to unpredictable DNA - copying errors — as opposed to the two
other main contributors to cancer, inherited
genes and environmental factors, such as smoking and
obesity.
Other accomplishments in this area include the mapping of variation in the FTO
gene for
obesity, characterizing the role of interleukin (IL)-6, IL - 10, and IL - 1RA in
obesity and insulin resistance in African Americans (AA), and determining the loci associated with CRP, IL - 10, IL - 1Ra, and IL - 6 levels in a GWAS of AA.
deCODE has discovered a
gene with certain variations that predispose to
obesity and
others that predispose to thinness Reykjavik, ICELAND, September 30, 2003 — deCODE genetics (Nasdaq / Nasdaq Europe: DCGN) today announced that it has achieved a milestone under its...
Soon several
other scientists revealed ADCY3 findings associating positive correlations between severe
obesity and mutations in the
gene.
We have identified common alleles of
genes that contribute significantly to both of the principal processes involved in
obesity — basic energy metabolism on the one hand and the regulation of appetite on the
other,» said Kari Stefansson, CEO of deCODE.
This seemingly small amounts of junk can also switch on
genes that trigger cancer, heart disease, Alzheimer's,
obesity, and
other common, preventable conditions.
Recent research into a field of science called nutrigenomics makes it safe and easy to use a simple home kit to examine your
genes for the presence of particular variants that predispose you to weakness in detoxification, Vitamin D metabolism, antioxidant processing,
other nutrient imbalances and certain conditions, such as
obesity, hypertension, diabetes and cardiovascular disease.
In the Diet,
Obesity, and
Gene (Diogenes) Project, increased protein consumption together with a modest reduction in glycemic index was beneficial for weight control.49 Substituting protein for carbohydrate also partly resulted in lower blood pressure, improved lipids levels, and concomitantly reduced cardiovascular risk.50 Higher vitamin D intake might have beneficial effects on the reduction of visceral adipose tissue51 and
other cardiovascular risk factors52.
Other ovarian cancer risk factors include certain
gene mutations, infertility, early menstruation,
obesity and age.
Dog breeds such as Labradors, Beagles, and Shelties are more prone to
obesity than
others, suggesting there is an inherited «fat
gene» in dogs.