Not exact matches
Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17
other lipids it was tested against, including cholesterol, glycolipids, and
other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two
phosphoinositides.
Investigators compared WR321, a non-human monoclonal IgG antibody that binds to
phosphoinositide lipids, developed by Dr. Gary Matyas at MHRP, with a human monoclonal IgG antibody that in recent studies was found to have lipid - binding characteristics, including binding to
phosphoinositides, but also bound to numerous
other lipids.
«For the first time, it appears that a monoclonal antibody that binds only to highly purified intracellular
phosphoinositide lipids, and not to any of 17
other types of lipids or to HIV protein, results in the secretion of HIV - inhibitory beta - chemokines.»