Sentences with phrase «other real effects»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Over time, as people became more and more aware of the effects commonly used products can have on the environment, plastic - happy clients who once cared mostly for cost and convenience morphed into savvy customers with real concerns about the impact polyethylene and other petroleum - based products have on the ecosystem.

It's efficiencies like these that make Rose think he and the 100,000 other individuals who compose Canada's plastics business — 400 of whom work at Layfield — are effecting real change in a sector not always known for boasting high levels of innovation.

Other characteristics that are shared due to the common methodology include: (1) The estimates encompass both transfers and changes in society's real resources (the latter being benefits in the context of the 2016 RIA but costs in this RIA because gains are forgone); (2) the estimates have a tendency toward overestimation in that they reflect an assumption that the April 2016 Fiduciary Rule will eliminate (rather than just reduce) underperformance associated with the practice of incentivizing broker recommendations through variable front - end - load sharing; and (3) the estimates have a tendency toward underestimation in that they represented only one negative effect (poor mutual fund selection) of one source of conflict (load sharing), in one market segment (IRA investments in front - load mutual funds).

Actual results could differ materially from those expressed in or implied by the forward - looking statements contained in this release because of a variety of factors, including conditions to, or changes in the timing of, proposed real estate and other transactions, prevailing interest rates and non-recurring charges, store closings, competitive pressures from specialty stores, general merchandise stores, off - price and discount stores, manufacturers» outlets, the Internet, mail - order catalogs and television shopping and general consumer spending levels, including the impact of the availability and level of consumer debt, the effect of weather and other factors identified in documents filed by the company with the Securities and Exchange Commission.

In effect, you'd be stripping cities and city - regions of real earnings with which they could reinvest and effectively transferring those earnings to keep other places on life support.

In nearly all real - world data, there are short - term fluctuations, random effects, and other influences that create «noise» in the values that we observe.

The effect will be to limit real estate lending to loans for the actual construction or purchase of buildings and other capital improvements, i.e., for tangible capital formation.

House values in other cities surrounding the 87 metros likely rose as well, due to the «halo» effect of real estate market appreciation.

not only is the placebo effect very real, you don't have to have any actual change interventional treatment (in other words, you don't need to add a sham treatment / placebo for the effect to be seen)-- just the increased attention and tracking / support by interested parties can improve clinical status

Third, the Eucharist has other values than effecting the real presence of Jesus.

the other curious thing is when theists go after the atheists over our knowledge of scripture, most atheists were once theists so we would have some idea of scripture like you all however with the onslaught of attacks from religious folks in the real world when they discover we're not «one of them» has the same effect as the villian in the comics unwittingly creating the superhero.

For while relations are real and can be experienced, forming the context of man's being and providing resources of energy and power which are greater and other than he, himself, can effect, they are also expressive of what he, in himself, represents.

But if some adults, even a few, believed «Gilligan «s Island» was real, imagine the effect other television programs have, programs which place much greater emphasis upon reality.

The absolutization of history and the ignoring of the effects of a real nature upon historical events has had other negative consequences against which Kantian theology does little to protect us.

In other words, it is not the lie that matters, but only its real effects, and since the effects are not big enough, realist supporters of Obama can dismiss the importance of this issue.

The naturalists on the other hand, with a powerful impetus from Aristotle, took the categories of physics and biology such as form and matter, time and space, cause and effect, and sought real being in that which man shares with all nature.

I wonder if we could do a better job in the formation of Catholic thinkers — perhaps with Youth Education classes, perhaps in the Newman Centers — in preventing the assumption that the life of faith has to be compartmentalized away from all other mental activity, where it can have no real effect.

The knock on effect of this is that khedira would probably go juve to replace him so he won't be joining our rivals, and one of falqao or cavani would go juve meaning that Manu won't get one of them.plus the other would entertain a move to Real Madrid to replace hernandez.

A real man can manage his job and his family without letting either interrupt or effect the other!

Personally, after the amount of research I've done just on the topic of pregnancy and TOPICAL chemicals, oils, and other ingredients in health and beauty products, I remain incredibly skeptical of the idea that enough of the acid inside a stone could really enter a baby's bloodstream in amounts that would have a real, profound effect on pain.

Also, being a real estate investor myself, and very much not a leftist, I will offer some insights on the other secondary and less visible effects you might have missed.

Though the potential for technology to have such results is real and significant, other manifestations are far more advanced, and have already generated palpable effects on both intra-state and interstate relations.

He identified other negative effects of corruption as, posing a real threat to national security; eroding the development of a universal culture of good governance, democratic values, gender equality, human rights, justice and the rule of law.

Not unlike others, previous guest columnists included, the late supervisor preferred not to mention this referendum, or its real effect.

The effect is that he is damaging, in a serious way, the ability of other public services to cope: he will visit real damage on other services that are intimately linked to the NHS.

John Burns is a Binghamton area real estate developer who hopes the casino expansion will mean spin - off jobs and have the effect of trickling down to other sectors of the local economy.

«The combined effect of both parameters showed no real patterns, as some pollutants were more sensitive to changes in temperature and others to increased organic carbon content,» says Matyas Ripszam.

One common misinterpretation is that a P value of.05 implies a 95 percent probability that the effect is real (or, in other words, that the chance of a false positive is only 5 percent).

Beyond that, we now have the evidence that reinforces earlier findings on the effects of ambient pollution at large and can say that these effects are very likely real, not just loosely correlated or tied up with other economic issues like household migration dynamics.»

But it is a complicated picture: the effect that extra atmospheric CO2 has in these kind of experimental setups might not reflect its effects in the real world, where other factors — such as elevated heat, or changes in precipitation — come into play.

Some people think there is no way that the online world can have an effect on real life; others argue that social media is so influential that the Arab Spring was catalyzed by networking sites, says James Fowler, a political scientist at the University of California, San Diego, who led the study in collaboration with Facebook's data - science team.

The potential for harmful effects is especially real in the case of children and youths — with the higher threat of repeated injury and cumulative effects of concussions (and links to other serious neurological illnesses)-- accurate diagnosis and proper follow - up is essential.

A separate meta - analysis including studies directing rTMS at other brain regions revealed a mean weighted effect size of 0.33 (95 % CI: 0.17 to 0.50) in favor of real TMS.

«The real challenge is to tweak the addictive effect of drugs like nicotine or other psychostimulants without totally crushing the person's desire to pursue healthy behavior.»

These are rare, and while the diabetes risk is the most concerning, doctors need to balance these side effects with the real dangers of heart attack, stroke and other heart - related problems if people don't take statins and their cholesterol levels remain high.

Couple other things we find — a lot of these microbes in our body — fungus and bacteria and parasites — EMF's or electromagnetic frequencies have a real negative effect on making these infections worse.

There may be an influence but then... how do we know that in a real bodily context the other veggies don't have a powerful effect as well.

It can be a simple exercise tip or your complete workout, it can be your Killer abdominal training showing your real results or some simple safety tip which may help others, do let the world know about your experience and I promise by the Law of Cause and Effect, someone in your life will come at the right moment and help you out too.

Obviously the degree of toxicity also varies from chemical to chemical, some having immediate effect, others not showing their real dangers until years down the road.

Would dropping it have any real effect on my arsenic intake (if I eat other grains / grain - like foods)?

So what the science tells us is that there truly is no real division between the body and the mind and emotions, it's all part of the same web, and we know this from the research studies that have been done, groups at Harvard, Johns Hopkins, a lot of the big, very reputable universities are now actually doing research on this, and there are even journals, scientific and medical journals exploring what we call psychosomatic medicine, in other words the placebo effect.

But the literature is so sparse in this area that we can not make any real statements or predictions about the effects of fasting, other than that we just don't know, and that we should continue to emphasize the centrality of awareness, caution, and loving nourishment in moving forward.

Two business rivals who despise each other in real life unwittingly fall in Brexit shitstorm forecast, brexit predictions, brexit effects, brexit problems, brexit issues, brexit successes (no, seriously)

I'm a w4m date, other members are plenty of real effect amounts to find personals ads, e.: one side has image; posted today; bundle duplicates; include adult entertainment, adult.

Like any other kind of special effect, CGI is at its most effective when we're unable or unwilling to tell where the real world ends and the make - believe begins.

It doesn't try to show some drastic change, but it does attempt to convince others that change can indeed happen, it also never puts blame on one person, because obviously with marriage it is a joint effort, there will be trials and on other occasions it simply won't work, but time and commitment can change that, rarely can a simple film like this address so much in such limited issues, but sharp, often improvisational dialogue and strong performances create a very real and insightful piece that underplays everything for maximum effect, which works.

Kenneth Lonergan's Manchester By the Sea (six nominations) is another film by a real movie artist: a study of grief and the ways in which it is denied and displaced into other human activities which in turn have their effects on other people.

A large part of that is due to Rick Lazzarini's superb creature effects, which look real and physical, so there's none of the shoddy CGI you associate with other mid-to-late-90s effects movies (looking at you, Jumanji).

The use of 3D layers, CGI, and real - time effects create a look not seen in other productions.