A three - phase experiment was conducted on a doubled - haploid population derived from the cross RL4452 / AC Domain to determine if the resistance of a recently discovered gene (Lr2BS) worked with
other resistance genes to synergistically enhance resistance to leaf rust.
A plasmid in the E. coli carried the gene for extended spectrum cephalosporin resistance, as well as four
other resistance genes.
What is so encouraging about the first successful unpicking of a wheat gene that confers resistance to a devastating fungal disease is the promise it holds for deciphering
other resistance genes, en route to a natural barrier to infection, at a time when the fungus has already developed tolerance to most types of fungicides.
«We're also looking at as many genes as possible in the wild banana and screening them to identify
other resistance genes, not only for resistance to TR4 but to other diseases.»
Not exact matches
I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling
resistance in targeted antibody drugs, improving
gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and
other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.
Scientists could search within them for
resistance genes and
other desirable traits to use in engineering and breeding programs.
Researchers now have the tools to identify
resistance genes in wild bananas or
other plant species.
The bacteria behind gonorrhoea readily acquire
genes for resisting drugs and so from 2012, UK patients were given two antibiotics at once — azithromycin pills plus a ceftriaxone injection — so if bacteria acquired
resistance to one, they would be killed by the
other.
One of the newest banes of U.S. medical centers, a supervirulent and multidrug - resistant strain of Acinetobacter baumannii, likewise appears to have picked up most of its
resistance in
gene swaps with
other species.
The scientists also generated a panel of (reconstructed) ancestral and existing TRIM5
genes (19 total), expressed them in cultured cell lines, and exposed the cells to 16 different retroviruses (lentiviruses and
others) to see which TRIM5 versions conferred
resistance to which viruses.
When the team induced expression of the corresponding
gene in the leaves of two
other plant species (one closely related to S. lycopersicum and the
other more distantly related), both plants reacted to presence of the C. reflexa peptide with increased production of ethylene, and exhibited increased
resistance to C. reflexa infestation.
At this stage, the bacteriophage infected
other Salmonella cells, possibly also spreading novel virulence or
resistance genes, the authors say.
The activity of four transcription factors — proteins that regulate the expression of
other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment
resistance of the deadly brain tumor.
So even if you start off [with] say, a resistant type of staph infection, that line of staph organisms not only, will they be more resistant, but they may pass some of the
genes for that
resistance off to completely
other unrelated types of bacteria.
Genetic factors can contribute to the degree of longevity in at least two important ways: An individual may inherit certain genetic variations that predispose him or her to disease that decreases longevity;
other gene variants may confer disease
resistance, thereby increasing it.
The
gene for colistin
resistance can be easily spread to
other bacteria, making it likely that colistin
resistance will become widespread in the future.»
The researchers suspected those hyperactive
genes might be behind the
resistance — playing off each
other to create a smaller network within the larger tuberculosis response network.
Although many different malaria
resistance loci have been postulated over the years, this is one of very few that have stood up to stringent testing in a large multi-centre study; the
others include the
genes for sickle cell and the O blood group.
The team cut and pasted a bovine
gene for NRAMP1, a protein linked to
resistance against TB and
other bacterial infections, into fetal dairy cow genomes.
The
other glyphosate -
resistance mechanism involves the same
gene.
Still, the qualities that make it easier for certain bacteria to pick up the
resistance gene, and
other genes that enhance that one's performance, are unclear, the researchers report in the 1 March issue of Lancet Infectious Diseases.
The researchers also found
genes in these isolates that confer
resistance to numerous
other antibiotics, as well as
genes associated with decreased susceptibility to disinfectants.
Finally, the researchers found that the vancomycin - resistant enterococci (VRE) bacteria found in the untreated wastewater contains a
gene capable of transferring vancomycin
resistance to
other strains of bacteria.
By comparing differences in the
gene that confers antibiotic
resistance, as well as
other pieces of DNA, the team determined that 70 % of their samples included just five bacterial strains.
«Nevertheless, this
gene will be useful in combination with
other STB
resistance genes, and our study provides tools for rapid lab - based tracing of Stb6 in wheat breeding lines,» says Kanyuka.
Most
resistance genes, in wheat and
other plants, code for protein receptors located inside cells; the Stb6
gene codes for a receptor protein on the cell's surface.
The
genes encoding NDM - 1 and
other antibiotic
resistance factors are usually carried on plasmids — circular strands of DNA separate from the bacterial genome — making it easier for them to spread through populations.
«Because TIA - 1 is known to suppress COX - 2 expression in
other cells, we reasoned that the inactivation of the TIA - 1
gene would increase COX - 2 expression in neurons and, consequently, would increase
resistance to acute seizures,» he continues.
We assume that phages acquire
resistance genes from already resistant bacteria and then transfer those
genes to
other bacteria,» says Hilbert.
Researchers will also want to find out whether bacterial integrons of
other species can also pick up
genes besides those for antibiotic
resistance.
Others might be engineered to include nutrients like beta carotene, iron, and vitamin A. Instead of one
gene to fight off insects or disease, crops will be engineered with «stacks» of
resistance genes to prevent pests from evolving
resistance to a single approach.
They did, however, find copies of
genes related to CDR1, CDR2, and few
others that encode
other transporters associated with drug
resistance — although the way they function in C. krusei is unknown.
The
other possibility is that
resistance genes will migrate from the crop to the weeds.
«It is incredibly tempting to assume that antibiotics are promoting the spread of
resistance by increasing the rate at which bacteria share resistant
genes with each
other, but our research shows they often aren't.»
Others were similar to existing
resistance genes, but not precisely the same.
Gene therapy could impart this kind of
resistance to
others.
Previous research by Professor Keevil and Dr Warnes has proved copper's efficacy against norovirus, influenza and hospital superbugs, such as MRSA and Klebsiella, plus stopping the transfer of antibiotic
resistance genes to
other bacteria to create new superbugs.
Prof Bentzen from Dalhousie University said: «Although this study focused on MHC
genes in vertebrates, the evolutionary dynamics described in it likely apply to
other gene families, for example
resistance genes and those which prevent self - fertilization in plants (self - incompatibility loci) that are caught up in their own evolutionary races.»
Lee says the research team will measure the amount of methylation in patients» cells when they begin their treatment and the presence of
genes associated with irinotecan
resistance, among
other possible biomarkers.
By transferring only the
genes necessary for disease
resistance, Gray says the technique may leave the vine's
other traits intact.
Perhaps most alarming to some scientists is that 21 % of the lab moths carried the
resistance gene — a rate 10 times higher than that seen in any
other bug.
But because some of the
genes could indicate pathogenic characteristics — such as
resistance to antibiotics — the researchers want to learn more about the potential health implications, and whether
other buildings house similar biofilms.
Both the carbapenem
resistance and the colistin
resistance genes are on separate plasmids, which means in principle they could spread to
other bacteria.»
Many
other applications are arising — for example, Lapitan's lab discovered that inhibiting one
gene can broaden wheat's
resistance to the devastating Russian wheat aphid.
Non-flowering plants could also ensure the containment of
genes for herbicide
resistance (or
other traits conferred to the organisms), counteracting the concern that transgenic trees would spread their lab - produced genetics throughout nearby wild forest.
These
genes exist on plasmids, small segments of DNA that are capable of moving from one bacterium to another, potentially spreading antibiotic
resistance to
other bacterial species.
So for example, if one microbe is resistant to antibiotics and the
other one isn't, if we let them have sex, maybe one of them will pass the
resistance gene on to the
other one and we can figure out where it is by seeing how long it takes for that
gene to get from one microbe to the
other.
Under these conditions, natural selection may be favoring
genes that confer
resistance to disease, such as AIDS and malaria, or enhance reproductive fitness in
other ways, researchers said in a report in Science.
In
other research, a knockout of the
gene that encodes one type of lncRNA in mice conferred some
resistance to obesity caused by a high - fat diet.
But what our studies suggest is that there is a whole new universe where you can now screen for
other functions, like the ability to block conjugation or to induce the loss of
resistance genes.