So, I stay invested in equities in almost all markets, and let
my other risk reduction techniques do my work, rather than making large changes in asset allocation.
I have ordered several tests on an early - access basis and plan to make this test a standard tool for helping me to decide which of my patients may benefit from screening at an earlier age, breast MRIs, and
other risk reduction measures.
This discussion also does not consider any specific facts or circumstances that may be relevant to holders subject to special rules under the U.S. federal income tax laws, including, without limitation, certain former citizens or long - term residents of the United States, partnerships or other pass - through entities, real estate investment trusts, regulated investment companies, «controlled foreign corporations,» «passive foreign investment companies,» corporations that accumulate earnings to avoid U.S. federal income tax, banks, financial institutions, investment funds, insurance companies, brokers, dealers or traders in securities, commodities or currencies, tax - exempt organizations, tax - qualified retirement plans, persons subject to the alternative minimum tax, persons that own, or have owned, actually or constructively, more than 5 % of our common stock and persons holding our common stock as part of a hedging or conversion transaction or straddle, or a constructive sale, or
other risk reduction strategy.
Not exact matches
Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost
reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or
other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our
other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and
other customers, and the
risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or
other security attacks, information technology failures, or
other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and
other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any
reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and
other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and
other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and
other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the
risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among
other things.
These
risks and uncertainties include, among
others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and
other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a
reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those
risks and uncertainties described under the heading «
Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
Such
risks, uncertainties and
other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among
other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of
other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost
reduction efforts and restructuring costs and savings and
other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and
other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and
other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among
other things import / export) and
other laws and regulations in the U.S. and
other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the
risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the
other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20)
risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21)
risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22)
risks associated with third party contracts containing consent and / or
other provisions that may be triggered by the Rockwell merger agreement; (23)
risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.
The primary advantages for most companies entering the realm of franchising are capital, speed of growth, motivated management, and
risk reduction — but there are many
others as well.
Leading clinical investigations seeking to address cardiovascular
risk reduction beyond lowering LDL - C focus on interrupting the atherosclerotic process (e.g., plaque formation and instability) by beneficially affecting
other lipid, lipoprotein and inflammation biomarkers and cellular functions thought to be related to atherosclerosis and cardiovascular events.
Risks associated with the Consumer Discretionary sector include, among
others, apparel price deflation due to low - cost entries, high inventory levels and pressure from e-commerce players;
reduction in traditional advertising dollars; increasing household debt levels that could limit consumer appetite for discretionary purchases; declining consumer acceptance of new product introductions; and geopolitical uncertainty that could impact consumer sentiment.
if required or permitted by law, including as necessary to comply with the law, to protect the rights or safety of our website,
other users, or third parties (e.g., for fraud protection and credit
risk reduction purposes; for protecting and defending the rights or property of Vision Critical, its customers,
other users, or members of the public), or
If they are broadly in line with each
other, the United States
risks suffering, instead, the same consequences that Germany and China suffered, with
reduction in both desired and actual investment.
Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward - looking statements, including, without limitation: BlackBerry's ability to enhance its current products and services, or develop new products and services in a timely manner or at competitive prices, including
risks related to new product introductions;
risks related to BlackBerry's ability to mitigate the impact of the anticipated decline in BlackBerry's infrastructure access fees on its consolidated revenue by developing an integrated services and software offering; intense competition, rapid change and significant strategic alliances within BlackBerry's industry; BlackBerry's reliance on carrier partners and distributors;
risks associated with BlackBerry's foreign operations, including
risks related to recent political and economic developments in Venezuela and the impact of foreign currency restrictions;
risks relating to network disruptions and
other business interruptions, including costs, potential liabilities, lost revenues and reputational damage associated with service interruptions;
risks related to BlackBerry's ability to implement and to realize the anticipated benefits of its CORE program; BlackBerry's ability to maintain or increase its cash balance; security
risks; BlackBerry's ability to attract and retain key personnel;
risks related to intellectual property rights; BlackBerry's ability to expand and manage BlackBerry ® World ™;
risks related to the collection, storage, transmission, use and disclosure of confidential and personal information; BlackBerry's ability to manage inventory and asset
risk; BlackBerry's reliance on suppliers of functional components for its products and
risks relating to its supply chain; BlackBerry's ability to obtain rights to use software or components supplied by third parties; BlackBerry's ability to successfully maintain and enhance its brand;
risks related to government regulations, including regulations relating to encryption technology; BlackBerry's ability to continue to adapt to recent board and management changes and headcount
reductions; reliance on strategic alliances with third - party network infrastructure developers, software platform vendors and service platform vendors; BlackBerry's reliance on third - party manufacturers; potential defects and vulnerabilities in BlackBerry's products;
risks related to litigation, including litigation claims arising from BlackBerry's practice of providing forward - looking guidance; potential charges relating to the impairment of intangible assets recorded on BlackBerry's balance sheet;
risks as a result of actions of activist shareholders; government regulation of wireless spectrum and radio frequencies;
risks related to economic and geopolitical conditions;
risks associated with acquisitions; foreign exchange
risks; and difficulties in forecasting BlackBerry's financial results given the rapid technological changes, evolving industry standards, intense competition and short product life cycles that characterize the wireless communications industry.
Or, with the U.S. economy in structurally better shape than many
other economies, a
reduction in perceived global
risks could be another catalyst.
The Commissioner has criticized the government for, among
other things, its management of the environmental
risks associated with gas, oil and nuclear projects, as well as its greenhouse gas
reduction practices.
Examples of these
risks, uncertainties and
other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and
other international events; the
risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or
other disturbances to our information technology and
other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or
other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit
risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain
other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or
reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and
other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and
other factors set forth under «
Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.
One may wonder whether Duméry does not in fact compromise them through his own attempts to surpass
others, either in belittling the importance of the positive data through insufficient information or in compromising the results of phenomenology by a
reduction which
risks bringing us back to an immanentism of religious knowledge, which is really a transcendence of religious reality.
But if you believe that breastfeeding has a modest impact on the
risk of infection, then you can step back and say, «OK, it's totally reasonable for a family to weigh the modest
reduction in the
risk of infection against all the
other things that are going on in their lives and make their own decision.»
Although previous studies have found that breastfeeding provides a variety of benefits for babies, including apparently reducing the
risk of sudden infant death syndrome, or SIDS, the study is the first to demonstrate an overall
reduction in mortality among U.S. children, Rogan and
other experts said.
Personally, I think it's curious how many physicians and mothers - to - be place such a high emphasis on the 0.11 %
risk reduction of neonatal mortality from hospital births, while thinking nothing of engaging
other common practices (i.e. poor dietary habits, overuse of antibiotics, participation in contact sports) that certainly increase their child's lifetime
risk of chronic disease, injury, or even death.
Some
other circumstances may include: a complicated pregnancy,
risk of preterm delivery, maternal illness, maternal history of breast
reduction, flat or inverted nipples, multiple births, cesarean births, or a history of breastfeeding difficulties.
Fan use was associated with a greater
reduction in SIDS
risk in infants who shared a bed with an individual
other than their parents (AOR, 0.15; 95 % CI, 0.01 - 1.85) vs with a parent (0.40; 0.03 - 4.68).
Researchers say the results suggest that the recommendation to breastfeed infants should be included with
other SIDS
risk -
reduction information given to pregnant women.
Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented
others from making a recommendation for pacifier use as a
risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.
Mission: To prevent or delay the onset of alcohol and
other drug use, and to eliminate or reduce the high -
risk use of drugs and alcohol through the application and principles of
risk reduction and building - resiliency.
They add: «The greatest
reduction in
risk of developing metabolic
risk factor clustering observed for intermediate levels of physical activity and leisure time sitting was unexpected and suggests that moderate amounts of both moderate - to - vigorous physical activity and leisure time sitting may be sufficient to protect against developing metabolic
risk factor clustering over time... The lack of protection for the most active adults may reflect a chance finding, or confounding by
other factors such as wider use of prescription drugs by participants in less active groups.
Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent
reduction in the
risk of heart attack, according to new research from Washington University School of Medicine in St. Louis, the Broad Institute at Massachusetts Institute of Technology and Harvard, and
other institutions.
«This weight loss may not put these women at their ideal weight, but it made a significant
reduction in their
risk of cardiovascular and
other diseases,» said Rock.
My hope for the future is for major new
reductions in childhood deaths — they could fall by half by 2025 if we could deliver existing vaccines, malaria treatment, and today's
other lifesaving tools with 90 percent penetration to those at
risk.
«We are now getting a more clear idea of the opportunities for
risk reduction through behavior changes and
other health factors.
The authors stressed that the long - term
reduction in aggressive disease was observed only in men after more than a year of testosterone use, and the
risk of prostate cancer did not differ between gels and
other types of preparations.
«Certainly some places will see increased floods, but
other locations could even see a
reduction in flood
risk.»
This represented a significant
reduction in the
risk, i.e. 65 percent less, covering
other fractures too.
But research in the International Journal of Disaster
Risk Reduction suggests other nations in known tsunami risk areas have not yet followed s
Risk Reduction suggests
other nations in known tsunami
risk areas have not yet followed s
risk areas have not yet followed suit.
«PrEP promises to help to curb the rate of new HIV infections as part of a comprehensive prevention plan — including safer sex, regular «opt - out» HIV testing,
risk reduction counseling, and treatment of any
other sexually transmitted infections,» Dr. Balderson said.
Dr Kristensen said: «It will be interesting to see if these medications, which are increasingly used in IBD, lead to a
reduction in the
risk of heart failure and
other cardiovascular diseases.
The aim of the talk at the 2013 Meeting of the Americas, which is sponsored by the American Geophysical Union (AGU), is to focus on the specific role geoscientists can play in disaster
risk reduction and how their work should fit in with the roles played by
other experts for any given community.
This is a desirable feature for a helper drug as it would reduce the
risk of treatment failure due to factors
other than antibiotic resistance (e.g. biofilms, immunosuppression, etc.), allow dose
reduction for toxic antibiotics such as colistin, and possibly even prevent selection of resistant mutants» says Guardabassi.
«The magnitude of the
reduction in thickening of the carotid artery in the treatment group, relative to the control group, is similar to what has been observed in
other clinical trials in high
risk populations.
Reduced carbohydrate intake results in fast and sizeable
reductions of liver fat and
other cardiometabolic
risk factors in individuals suffering from obesity and fatty liver disease.
Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 %
reduction in
risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone therapy include
other cardiovascular diseases; endometrial, colorectal, and
other cancers; and
other fractures.3, 6,9
This drastic
reduction in cancer
risk is a great reason to eat these veggies daily, but there are
other cancer - protective benefits as well.
This includes exchanging information with
other companies and organizations for fraud protection and credit
risk reduction.
First off, carb restriction has been linked to loss of weight and visceral fat,
reductions in insulin and blood sugar levels, and improvements in
other cardiac disease
risk factors in those with metabolic syndrome.
A
reduction * in homocysteine lowers the
risk of stroke or any
other cognitive impairment in a person.
As these microbes ferment fiber in the intestine, short - chain fatty acids and
other metabolites are produced, resulting in many health benefits, including a
reduction in the
risk for type 2 diabetes, obesity, inflammatory bowel disease, colon cancer, and autoimmune disorders.
Massive
reductions in cancer
risk in humans and also highly effective as a cancer intervention, particularly prostate and breast but also many
others.
- Elderly people with positive attitudes have an over twenty percent
reduction in
risk of death from cardiovascular disease and over fifty percent lower
risk from all
other causes.
Together with a small but significant
reduction in blood pressure, there is also a concomitant significant increase in several
other risk factors for diabetes and cardiovascular disease.
In this study of 12 patients with elevated LDL cholesterol levels, a diet containing almonds and
other nuts, plant sterols (also found in nuts), and soluble fiber (in high amounts in beans, oats, pears) reduced blood levels of all LDL fractions including small dense LDL (the type that most increases
risk for cardiovascular disease) with near maximal
reductions seen after only 2 weeks.
Some of the health - giving attributes of omega - 3's include the following: regulation of inflammation, alleviation of pain, prevention of excessive blood clotting, maintenance of the integrity of cell membranes,
reduction in elevated cholesterol and triglycerides, optimal fetal development, reduced cardiovascular
risk factors, anti-cancer properties, better cognitive function, reduced incidence of depression, among many
others.