Sentences with phrase «other single gene»

Not exact matches

anemia and others result from a misplaced base letter in a single gene.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

Researchers from Duke University had previously used CRISPR to correct genetic mutations in cultured cells from Duchenne patients, and other labs had corrected genes in single - cell embryos in a laboratory environment.

In these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to function.

Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research from Washington University School of Medicine in St. Louis, the Broad Institute at Massachusetts Institute of Technology and Harvard, and other institutions.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

Other single - gene mutations gave the flies an extra set of wings or removed its eyes or wings completely.

Inheriting a single X chromosome exposes men to a host of X-linked diseases, such as hemophilia or Duchenne muscular dystrophy, and researchers hope to use the new data to understand more fully the role of genes in other X-linked conditions.

On the other hand, gene variants that confer a benefit to males are more likely to accumulate on the X chromosome than on a nonsex chromosome because they will always be expressed on a male's single X chromosome.

It cost them about $ 900 to knock out a single gene in a group of Parhyale embryos with their other method.

Other researchers had linked the ank mutation to mouse chromosome 15; in this week's Science, Kingsley's team reports that it's a single typo in a previously unknown gene, which they called ank, that led to a protein about 10 % shorter than the normal version.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

If youdisable the gene for a single vomeronasal protein in mice, a male mouseloses his ability to distinguish other males from females and will tryto mate with both.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

The success with CF suggests that they can model other single - gene disorders, such as α - 1 antitrypsin deficiency, which causes symptoms primarily in the lungs and liver.

Fifty - four per cent were single gene mutations, and the other 13 per cent were polygenic DNA variants, meaning they were a combination of multiple bad genes inherited together.

On the other end of the spectrum are Mendelian diseases such as cystic fibrosis and sickle - cell anemia, which are caused by abnormalities to a single gene.

Others might be engineered to include nutrients like beta carotene, iron, and vitamin A. Instead of one gene to fight off insects or disease, crops will be engineered with «stacks» of resistance genes to prevent pests from evolving resistance to a single approach.

He focused on the 2300 genes that exist in single copies in all the bats, the dolphin, and at least five other mammals.

In other words, type 2 diabetes could never make it into the Finnish Disease Heritage, where a change in a single gene is decisive.

It is particularly useful when clinicians want to identify an illness or gene mutation involving a single patient or the patient and two or three other family members, which is the most common clinical situation for undiagnosed diseases.

To make BinoX directly usable for other researchers, a public web server http://PathwaX.sbc.su.se (Ogris et al., 2016b) was set up for on - line pathway analysis of single gene sets, which applies the BinoX algorithm to all KEGG pathways and FunCoup networks.

It's now known that single gene mutations in other organisms can lengthen life span.

The researchers then identified children, among other families, who carried the single candidate gene.

It also opens up possible new treatment approaches for other diseases that have thus far required more intrusive methods to correct single - gene mutations.

The strategy of single - cut editing may be useful for treating other single - gene diseases, Dr. Olson said.

Examining a handful of genes, Keeling and other researchers demonstrated that the single - gene tree had put microsporidia in the wrong kingdom.

«This is an important finding that will help future researchers, and eventually physicians, to maximize the effectiveness of gene therapy for curtailing sensory deficits associated with USH3 syndrome and, perhaps, in other disorders linked to defects in single genes,» said Alagramam.

«The chance of the gene being lost over and over again in the other lineages seems vanishingly small compared with a single transfer from a metazoan to a bacteria.»

The team also compared the 7442 genes found as single copies in both the cobra and the python with the same genes in all other land vertebrates sequenced so far.

In the years after finding the CFTR gene at the root of the disease, Collins, Tsui and others discovered the situation was far more complex than they had ever dreamed: Instead of just a single mutation in the gene, researchers found some 1,900 distinct mutations.

Unlike some other common vision disorders, such as age - related macular degneration, color blindness is a heritable disorder caused by a single gene that is defective or absent.

Researchers at Princeton observed that transcription occurs in bursts in response to a single enhancer acting simultaneously at two genes, one labeled with green dye in the left panel and the other labeled with red dye in the middle panel.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

«So there could be a large effect of a single gene, but there is some other factor necessary for developing disease,» says Richard Lifton at Yale University, Connecticut, US, who led the new research.

Because you have her whole genome, and not just a test for a single gene, you can potentially look for a vast number of other gene variants that raise the risk of other diseases of adulthood, such as the BRCA1 gene for breast cancer.

Because it would not be feasible for a single laboratory to study each of the 50 or more genes implicated in type 1 diabetes with this approach, they decided to prioritize those genes that are also associated with other autoimmune diseases.

Scientists at the Gladstone Institutes linked a single gene mutation to two types of heart disease: one causes a hole in the heart of infants, and the other causes heart failure.

Ultimately, the combination of this new method of focusing on gene activity in single cells with other single - cell techniques involving microscopic imaging is likely to reveal the origins of developmental disorders of the brain, he added.

Two genes critical to the immune system's adaptability in battling viruses, bacteria and other invaders receive on and off signals from a single DNA segment, HHMI researchers have found.

For example, other researchers think it's possible that there could be some cell hosting just a single gene inside a membrane.

The initial goal of the project is to establish a large collection of Drosophila strains that each contain a single genetically engineered P transposable element insertion that mutates a different gene, in a genome free of other P elements.

Genes aren't single - function, self - contained switches, and we're only just beginning to learn how they interact — both with other genes and with environmental and lifestyle factors — to create living, unique human beGenes aren't single - function, self - contained switches, and we're only just beginning to learn how they interact — both with other genes and with environmental and lifestyle factors — to create living, unique human begenes and with environmental and lifestyle factors — to create living, unique human beings.

The comparison suggests that the ancestors of Ancient Beringians and those of other Native Americans descended from a single founding population that first split from East Asians around 36,000 years ago, although gene flow with North Eurasians — possibly centered around Lake Baikal in southern Siberia — continued until about 25,000 years ago.

These so - called Mendelian disorders — single - gene diseases, such as cystic fibrosis, Huntington's disease, and many others, — have been studied for decades.

That a single gene could fuel cancer's runaway proliferation in such different ways underscores the importance of SIRT6 and other chromatin factors.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

As a disease caused by a mistake on a single gene, Huntington's disease is an ideal model for other brain disorders.

Kmiec noted that while some ailments, like sickle cell anemia and Huntington's disease, involve faulty DNA within a single gene, others, like Alzheimer's and heart disease, appear to involve malfunctions in multiple genes where the best option «is not really gene editing, but gene replacement.»

«The microarrays allowed us to assay every single gene that was in the original sequence strain for its presence or absence in the other strains,» says Israel.