Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and
other small molecule drug cadherin - 11 inhibitors.
Not exact matches
«We could apply the strategy used in this study to quickly identify and design
small molecule drugs for
other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.
«Our findings will promote the development of specific
small -
molecule drugs useful to treat Graves» disease and
other dysfunctions of GPHRs.»
The approach should work with
other small -
molecule drugs and may lend itself to multiplexing, he notes, so numerous
drugs could be measured at the same time.
However, this security system is so effective at protecting the brain that it prevents many life - saving
drugs — all but some
small molecules — from being able to treat cancer and
other diseases of the brain.
«They also provide a promising strategy for identifying
small molecule drugs designed to treat Alzheimer's disease and
other neurological disorders.»
The basic problem the team faced with these and
other vaccines they've developed is that the opioid
drugs are
small molecules, which are not recognized by the immune system.
Dr. Ding's work revolves around chemical reprogramming — the use of
small molecule drug mixtures to coax fibroblasts into becoming a variety of
other cell types.
Other companies, including the Swiss
drug giants Novartis and Roche, along with Boston's Paratek Pharmaceuticals, are developing ingestible
small -
molecule drugs designed to increase the inclusion of SMN2 «s exon 7.