Sentences with phrase «other therapeutic targets»
Automatically modeling «hidden» multiple conformations of proteins using our algorithm may help drive biomedically relevant insights in structural biology pertaining to, e.g., drug discovery for HIV — 1 protease and other therapeutic targets.
https://www.bioxfel.org/
«In order to find other therapeutic targets you have to find something that you can actually hit, but NRF2 has a protein half - life of like 20 minutes, so you don't have a large window to target that protein.
Not exact matches
«SiteOne's therapeutic candidates exhibit impressive potency and selectivity for NaV1.7, and engage the target in a way that differentiates them from other inhibitors of Nav1.7.
Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.
Since molecules that target CCR3 have already been developed by the pharmaceutical industry for other diseases, the researchers are now hoping to explore this new therapeutic pathway, which could reduce the aggressiveness of prostate cancer in obese patients.
«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.»
Remarkably, when the researchers manipulated the activity of these three genes, almost all of the other genes in the network were corrected, pointing to novel therapeutic targets for CAVD.
The researchers hope that a better understanding of how Ras proteins cluster together and interact with other proteins in cells will bring them one step closer to developing therapeutic targets for Ras - driven tumors.
«These findings could lead to a new therapeutic strategy for patients with AML and potentially other diseases by targeting patients whose leukemia cells display activation of a specific survival pathway.»
LncRNAs are intriguing therapeutic targets — recent studies by Khalil and others have implicated lncRNAs defects in all kinds of diseases, including infertility and cancer.
«We believe that the reestablishment of proper cell transport could provide a promising therapeutic target for Huntington's disease, and potentially other neurodegenerative disorders.»
Furthermore, results may encourage other research groups to use the M2 channel of influenza virus as therapeutic target against the influenza A virus.
The other contribution of this study was the identification of potential alternative therapeutic targets.
In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug - resistant tumors vulnerable to other therapies.
Other researchers at Joslin are conducting large scale genetic screening for novel therapeutic targets to control autoimmunity, which will complement the effort of BAIRT to extend autologous beta cell replacement to patients with type 1 diabetes.
Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and technologies with high therapeutic potential.
So scientists have begun looking for other targets for which they can develop new therapeutic strategies.
In other words, Ras proteins naturally lack areas that are accessible, high - affinity binding targets for potential therapeutic agents.
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
«Our research on the role of blood proteins in brain functions has identified new targets for therapeutic intervention in multiple sclerosis and other neurological diseases,» said Dr. Akassoglou.
â $ œWe have solved a major obstacle of using anti-miRNA as a therapeutic by being able to do a targeted delivery to only inflamed endothelial cells while all other tissues examined, including liver, lung, kidney, blood cells, spleen, etc showed no detectable side - effects, â $ Jo says.
«We think this development will help other scientists better utilize open data, hopefully leading to the discovery of new therapeutic targets for disease,» says first author Andra Waagmeester, PhD, formerly a researcher at Maastricht University and now CEO of the start - up company Micelio.
Its lead therapeutic programs, which leverage the company's expertise in chemistry and structural biology, include DG041, an antiplatelet compound being developed for the prevention of arterial thrombosis; DG051 and DG031, compounds targeting the leukotriene pathway for the prevention of heart attack; and DG071 and a platform for other PDE4 modulators with therapeutic applications in Alzheimer's disease and other conditions.
«The inflammation resolving targeted nanoparticles have shown exciting potential not only for the potential treatment of atherosclerosis as described here, but also other therapeutic areas including wound repair, for example, as described in the Feb. 9 online issue of Journal of Clinical Investigation, in addition to other applications currently underway with our collaborators,» Farokhzad said.
These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.
The ultimate goal of this work is to contribute to the design of effective therapeutic approaches that target dysregulated ER functions for patients with leukemia and other malignancies.
She thinks fibrinogen could be a therapeutic target for multiple sclerosis and many other neurological diseases.
Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.
Our goal is to identify novel therapeutic targets and participate in both preclinical and clinical studies of new drugs and other interventions.
«By finding out what is altered in TGF - β and other signaling pathways, we hope to identify better therapeutic targets for the treatment or even prevention of HD.»
ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders; small - molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4 on mitochondria and the cytoskeleton; small - molecule protease inhibitors to block the formation of toxic fragments of apoE4; Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver; Plasma HDL cholesterol (HDL - C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL - C levels established by the Turkish Heart Study.
This study identified 1,317 distinct genes found to be knocked out in humans; many of these genes (e.g., APOC3, PLA2G7, LPA) are being pursued as therapeutic targets, whereas many others are novel genes of unknown function.
Provenge and other therapeutic vaccines involve personalized therapy that targets the patient's specific tumor.
Their pipeline includes therapeutic candidates targeting pain, inappetence, cancer, viral diseases, allergy, and other serious, unmet or underserved medical needs.
Intensive, long - term, early intervention support for children, young people and their families which may include: assessment and identification of needs; practical assistance and home - based support; linking with other relevant services; and, targeted therapeutic groups.
From a therapeutic perspective, the protective separation is needed in order to protect the child from being turned into a «psychological battleground» by the continuing psychological pressures applied to the child by the narcissistic / (borderline) parent designed to maintain the child's symptomatic rejection of the other parent even while therapy is trying to restore the child's affectionally bonded relationship with the targeted parent.
TARGET is an educational and therapeutic intervention designed to prevent and treat traumatic stress disorders (including PTSD, severe anxiety disorders, depression, and dissociative disorders), co-occurring addictive, personality, or psychotic disorders, and adjustment disorders related to other types of stressors.