Sentences with phrase «other times the cell»

At other times the cell would be just an aggregate.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

At this time, trials and plans for its other CD19 - directed chimeric antigen receptor (CAR) T - cell product candidates, including JCAR017, are not affected.

One of the key caveats at the time, however, was that the technique required the use of a virus to introduce several genes into the skin (or other) cell, and these would remain in the cell, and so might contaminate the resulting stem cell or create cancer risks.

It is time we start believing in each other and in the physical time we have on this planet and stop blowing ourselves up, shooting at others, and preaching ridiculous social maladies (i.e., pro-life (really anti-life), anti-stem cell, anti-gay, anti-evolution, anti-big bang, anti-truth) that is imposing a theocratic political and social environment on the rest of us who hold reality near and ear to our hearts.

In the presence of the three intrinsically distinct, intelligible, and existentially necessary primary notions of temporal passage, modality, and order together with their derivative relations, and in the absence of any successful reductions known to me of one of these to the others, I am inclined to regard a synthetic metaphysics of time which has a place for each of the nine cells of the matrix as the only kind which could be adequate to all the facets of time.

Solzhenitsyn even blesses his prison cell for having purged him of the confusion of his age, for once on the other side of history — free from the petty progressive notions of one's time — one enters history in a new way, as a witness to the inner force that intuitively resists oppression born of the human will to power.

It has brought healing, conveniences, communications, and knowledge unimaginable in earlier times, but on the other hand it has brought advanced killing technology, pollution, and embryonic stem cell research.

you can believe in a mystical being who created all the matter and life in the universe, yet refuses to display definitive proof of its existence to us, or you can believe that the proper amount of protein, electrolytes, sugars, and RNA came together in a lipid layer (or some other semi permeable membrane) at just the right time to create a cell that could reproduce itself and begin life.

Second, keeping the starter volume the same helps balance the pH. And third, keeping the volume down offers the yeast more food to eat each time you feed it; it's not fighting with quite so many other little yeast cells to get enough to eat.

Agave and fructose in general does not spike blood sugar because it goes through your liver damaging it at the same time, glucose is processed by other cells as well and thus it spikes your blood sugar, but fructose is processed just by the liver.

The change in load cell output occurring with time, while under load, and with all environmental conditions and other variables remaining constant; usually measured with Rated Load applied and expressed as a percent of Rated Output over a specific period of time.

You may need to take away your teen's cell phone or other electronics during homework time if your teen tends to be easily distracted.

Iron rich foods are extremely important during this time of your pregnancy since your baby needs the extra iron to make red blood cells along with many other developments.

They should function as storage and wallet at the same time for other things which you will need frequently, such as pacifiers, wipes and cell phone at your own convenience.

Others will park themselves in a chair their whole shift and think no ones knows that they are playing with their cell phone the entire time.

Since meconium is made of amniotic fluid, mucus, skin cells, and other stuff ingested in utero, it doesn't really smell — so you may not realize it's time for a diaper change.

When possible, limit your time using your cell phone and other devices.

Regular Epolitics.com contributor and digital Laura Packard (of PowerThru Consulting) is back with us, this time to help you survive the onslaught of cell phones and other mobile devices.

Cell phones, smart phones, and other personal electronic devices are free from arbitrary police snooping in California — at least for the time being, thanks to actions taken by the state legislature and Governor Jerry Brown.

While other papers have examined these mutations using expensive and time - consuming experiments on live ferrets and laboratory cell cultures, Deem and Melia Bonomo used the pEpitope method to rapidly calculate how much the egg - passage mutations would decrease vaccine efficacy in humans.

In 2014, for example, according to data in the article, stem cell researchers between 35 and 39 were successful more often than any other age group, winning grants 21.6 % of the time, as compared to success rates ranging from 18.3 % for those between 40 and 44 to 13.4 % for those in the 55 to 59 age group.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

A colony of cells could now improve both traits at the same time, by making some cells exclusively reproducers and others survivors.

BEATING heart muscle cells have for the first time been made directly from other heart cells.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

The cells waste no time finding their cancerous cousins, slashing their way through a lab - prepared gel to quickly join other melanoma cells and form tumors.

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

However, recent research demonstrated that cells in other parts of the body — including the lungs and liver — keep their own time.

Such a lag time, says Hahn, could allow cancer cells to develop resistance to a drug by finding some other way to maintain their telomeres.

The process the team came up with to produce the synthetic environments takes an estimated 15 minutes, discounting the time it takes to grow the cells and a few other steps, Grolman said.

The body contains 10 times more bacteria, fungi and other micro-organisms than human cells.

Malaria, on the other hand, ebbs and flows over time, so the physiological benefits associated with the sickle - cell allele may be tempered.

«For a long time now, the entire field was collecting data on MYC, LIN41, and other genes and proteins without knowing what most of it meant,» said Yamanaka, who is also director of the Center for iPS Cell Research and Application (CiRA) at Kyoto University, and professor at UC San Francisco.

By devising a dual - objective system with two microscope lenses facing each other, Xu and colleagues viewed the front and back of the sample at the same time and achieved unprecedented optical resolution (of approximately 10 nanometers) of a cell.

«This evidence suggests that the DNA timing mechanism is highly conserved, and it is possible that other time - critical functions related to the cell cycle may be regulated in a similar way.

The increased surface area of the rippling «leaf» creates three times as many catalytic contact points as other molybdenum disulfide structures, and the new creation can handle higher temperatures than platinum without sintering and gumming up the cell.

Other cell detection techniques could help refine the results sufficiently to allow the technique to put a precise timing on when a rape happened.

As with all of our other genes, the DNA that encodes the telomerase enzyme is present in all of our cells — but because it's needed only after quite a few cell divisions have occurred, it's not needed in most cells for most or all of the time, so it's turned off.

It shows that indeed you can make cells that talk to each other and they can change the composition of the material over time,» Lu says.

FIH is found in all the body's cells and tissues, but is 50 to 100 times more abundant in the muscles than in any other part of the body.

«We showed that one drug can deliver the other drug to sites inside the cells where the virus grows and at the same time sequester the drug crystals at sites protecting it from degradation,» she said.

By the time the learning period was over, cells were phase locked to the oscillation and a large portion of the cells responded specifically to one or the other of the smell - odor pairs.

One cell line produced ten times more than any of the others, most produced very few, and some produced none at all.

The network of molecules and cells, second in complexity only to the brain, remains a paradox: sometimes it promotes cancer; other times it hinders disease.

Many other species, such as fish and birds, can regenerate the hair cells in their inner ear over time and create new auditory circuits, says Klickstein.

For the first time, stem cell researchers have succeeded in getting transplanted nerve cells to establish connections with other neurons to improve movement in paralyzed rats.

The tool will enable better phenotyping of cell shapes and also understanding of how cell shapes change in relation to others, and over time.

Published in Nature Communications, the study shows that as egg cells mature in older women, paired copies of matching chromosomes often separate from each other at the wrong time, leading to early division of chromosomes and their incorrect segregation into mature egg cells.

The microbes rely on oxygen, carbon and other nutrients in their deep environment to live, but Røy's team found that carbon is so limited that the cells respire oxygen 10,000 times slower than bacteria in lab - grown cultures.