Sentences with phrase «other types of cancer cells»
«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.
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Production of the enzyme asparagine synthetase is deficient in ALL and several other types of cancer cells, which are therefore unable to synthesize the amino acid asparagine.
The researchers studied triple - negative breast cancer cells, which grow and spread faster than most other types of cancer cells.
Marcus stresses that SaGA can be applied to additional cell types or environments, or other types of cancer cell behavior such as drug resistance.
Not exact matches
It also sought to match epigenetic changes and genetic differences to the physical characteristics of each cell type and use this knowledge to understand how these can lead to blood disorders, cancer and other complex diseases.
In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.
The data that the breast cancer cells spread more successfully in clumps are compelling, D'Souza - Schorey said, but no one yet knows whether cells from other types of cancer also need help to migrate.
«We'd like to extend this further to examine for driver genes in other types of lung cancer, such as squamous cell lung cancer.»
The researchers have shown that it is possible to produce chromosome modifications in human cells that are genetically identical to those observed in leukemia and other types of human cancer.
Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.
The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.
COUNTLESS research projects around the world into cancer and other major diseases are producing bogus or misleading results because investigators are studying the wrong type of cell.
«But mounting evidence confirming angiotropism and EVMM has revolutionized the knowledge of how cancer spreads through the body to the point that other scientists have confirmed the process in other solid tumor cell types such as pancreatic cancer.»
The papillary cell type represents only about 1 in 10 of these; other cancers are even less common.
Cancer stem cells are strongly associated with the growth and recurrence of all cancers and are especially difficult to eradicate with normal treatment, which also leads to tumours developing resistance to other types of therapy.
Researchers do not know if the same thing would work for other types of cancer or cancer cells lodged in other body organs.
The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.
Hydrochlorothiazide increased the risk of basal cell carcinoma, which is the least serious type of skin cancer, as well as of squamous cell carcinoma, which is more aggressive and in some cases manages to spread to other parts of the body.
The findings, which were published online in the journal Cancer Cell, could ultimately lead to new targeted therapies for many other types of cancer carrying similar p53 mutaCancer Cell, could ultimately lead to new targeted therapies for many other types of cancer carrying similar p53 mutacancer carrying similar p53 mutations.
«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.
«Since patients with many types of cancer have elevated levels of myeloisd cells in their blood, it's possible that other tumors could have a similar interaction with bone to increase myeloid cell production.»
Professor Miyazaki continues, «It is surprising that we do have an excellent system to eliminate undesired cancer cells, and that this system may certainly be therapeutically applicable not only to HCC, but also more broadly to other types of cancer.»
Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.
«Our work outlines the genetic similarities of the tissue and cells in different types of tumors and shows the strong relationships mice can have to other human cancers too.»
According to its developers, the technique can be applied to assess mutation dynamics in other types of cells, even human cancer cells.
This new combination approach prevents cancer cells from changing their diet (metabolically inflexible), and effectively starves them, by preventing them from using any other available types of bio-fuels.
There are other types of skin cancers that are less concerning, mainly squamous cell carcinoma and basal cell carcinoma, which tend to be (thankfully) much more common than melanoma.
The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating in the blood and the other resident in tissues — that can be reactivated with current immunotherapy strategies.
The single - cell - analysis approach could likely be employed to develop personalized treatment for many other types of cancer as well.
Cancer cells resemble stem cells not because they can turn into other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers of stop signs and barricades and just keep on multiplying.
The team found evidence of the process in several other cell types, including breast, ovarian, umbilical cord, and kidney cancer cells.
In further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancers.
Jacks» lab is now investigating the roles of genes associated with other types of lung cancer, such as small cell lung cancer.
Some cancer types, even when cancerous cells have traveled to other areas of the body, such as testicular seminoma and leukaemias and lymphomas in children, can have high cure rates if appropriate treatment is provided.
«A growing body of evidence suggests that exosomes can facilitate crosstalk between cancer cells and other types of cells that are nearby in the microenvironment that surrounds the tumor,» said Hongyun Zhao, the first author of the eLife study.
Professor Chien's research on how blood flow regulates interaction between the blood stream, blood cells and artery walls also leads to new information relevant to other types of cells, e.g., stem cells and cancer cells.
Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.
Because stem cells can become bone, muscle, cartilage and other specialized types of cells, they have the potential to treat many diseases, including Parkinson's, Alzheimer's, diabetes and cancer.
He continues to investigate and optimize CAR T cell therapy, to make it more effective not only for blood cancers, but also to help patients with other types of cancer.
FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer types as well.
Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.
«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.
The study relates to a particular type of vaccine (killed) against a particular virus, influenza, though the findings might hold true for other killed vaccines and for those vaccines consisting only of proteins produced by GM in bacteria, yeast or insect cells, against diseases such as hepatitis B (HBV) and human papilloma virus (HPV, the causative agent of cervical cancer).
After the chemotherapy drug has eliminated enough of the most prolific cancer cell types, the other cells that have survived are resistant to the drug and now have less competition for space and nutrients.
Other Cancers: Distribution of Other Cancer Types in Arab States; Basal Cell Carcinoma (Qatar), Basal Cell Nevus Syndrome (Egypt), Becker Nevus Syndrome (Saudi Arabia)...
In the case of cellular amino acid homeostasis, many examples will be drawn from cancer cells, for which the understanding is more complete than for other cell types.
In cancer, Tregs are recruited by tumors and prevent other types of T cells, including cytotoxic T cells (also called CD8 cells) from attacking and destroying cancer cells.
Similar to primary keratinocytes, long - term — cultured squamous cell carcinoma (30) and many other epithelial cancer cells (30, 31) can also form different types of clones in culture.
The most potent peptide, MA5, could bind to adenocarcinoma cells, which make up 95 percent of all colon cancers, 150 times more strongly than other cell types and be transferred inside cells within 2 hours.
«Those profiles can tell you the different types of cancer; they can tell you the different types of cells; they can distinguish stem cells from other cells; and they can distinguish skin cells from brain cells.