The group is also testing four
other types of stem cells.
They also believe that SIRT1 might be important to maintaining the health of
other types of stem cells in the body, which may be linked to overall aging.
hESC researchers George Daley of Children's Hospital Boston and Sean Morrison of the University of Michigan told the panel why research on
other types of stem cells, such as adult stem cells and so - called induced pluripotent stem cells (iPSCs), can't substitute for work on embryonic cells.
He added: «Truly naive human ES cell lines would not only help answer fundamental questions about how we are made, and be useful for drug screening and tissue therapy, but they would also provide a benchmark against which
other types of stem cells could be measured in terms of their effectiveness in stem cell therapy and regenerative medicine.»
«Now that we know a fetus can become tolerant to a foreign stem cell source, we can really think big and consider looking at how
other types of stem cells might be used to treat everything from neurological disorders to muscular disorders before birth,» MacKenzie added.
Now those early results are pointing researchers toward
other types of stem cells that may be better suited to help repair cardiac muscle.
In the Drosophila testis, however, the whole system has been laid out, and stem cells can be readily identified — a major hurdle for most
other types of stem cells.
Other types of stem cells are capable of creating multiple different cell types, but not all the cell types in the body.
Not exact matches
Instead, after several days, researchers harvest embryonic
stem cells, which theoretically can develop into any
type of cell and, according to many researchers, may someday be used to treat neurodegenerative diseases or
other conditions.
The researchers dialed the skin
cells back, developmentally speaking, to produce induced pluripotent
stem cells (iPSCs)-- a special
type of cell that can both self - renew, making more iPSCs, and differentiate, specializing into almost any
other cell type.
Neuronal
stem cells are marked by their ability to differentiate into
other types of cells.
Some
of the researchers at the centre will study the differentiation
of stem cells into
other cell types, one group by using human embryonic
stem cell biology and another by studying early embryo development.
Other adult
stems cells exist — such as hematopoietic
stem cells, which can generate all
types of blood
cell and mesenchymal
stem cells, which can turn into bone, fat and cartilage
cells.
Also, researchers could carefully select which blood
types to culture with each batch
of stem cells, creating stockpiles
of needed blood products for people with extremely rare blood
types whose blood
cell makeup makes it challenging to find good blood matches for transfusions because they would reject most
other types of blood.
The back - and - forth attachment and removal
of methyl groups also fine - tunes gene expression in
stem cells, which can mature, specialize and multiply to become muscle, bone, nerve, or
other cell types.
They then tried to reprogram skin
cells from the animals, turning them into induced pluripotent
stem cells (iPS), which are capable
of forming
other types of cell.
These so - called pluripotent
stem cells can be derived from a variety
of adult
cells and be guided into almost any
other tissue
type.
Now, with new kinds
of technologies that are coming up, new
types of tissue engineering and, you know, some
of the hopes that people have for
stem cells and [the] like, it may be interesting to see if there are
other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.
Meanwhile, biologists elsewhere were whipping up
other types of organoids, starting instead with adult
stem cells.
Cancer
stem cells are strongly associated with the growth and recurrence
of all cancers and are especially difficult to eradicate with normal treatment, which also leads to tumours developing resistance to
other types of therapy.
The
stem cell model says that tumor growth is more hierarchical, mainly driven by a subset
of cells that can make new copies
of themselves and give rise to the
other cell types the tumor contains.
«Because
of the Harvard
Stem Cell Institute, we were able to work with
other researchers to make patient
cells into any
type of neuron,» said Young - Pearse, whose lab spent two years fine - tuning protocols with collaborators to generate the neurons needed for her early onset Alzheimer's study.
«There have been previous reports
of other labs deriving beta
cell types from
stem cells, no
other group has produced mature beta
cells as suitable for use in patients,» he said.
To create different
cell types in the lab,
stem cells must be coaxed down the road
of determination — the branching paths that fetal
cells normally travel to become neurons, skin
cells, muscle
cells, or any number
of other cell types.
«Use
of induced pluripotent
stem cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them into embryonic - like
stem cells capable
of turning into
other specific
cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie
of KU Leuven.
«We don't yet know if this
type of coordination and control works in
stem cell niches
of other tissue
types,» says DiNardo.
Stem cells obtained from human embryos seem to offer the best chance of new therapies, because unlike other stem cells they have the ability to morph into almost any type of tis
Stem cells obtained from human embryos seem to offer the best chance
of new therapies, because unlike
other stem cells they have the ability to morph into almost any type of tis
stem cells they have the ability to morph into almost any
type of tissue.
In a matter
of weeks, the single
stem cell repopulated the mouse's blood and immune system but did not create
other types of cells.
While
stem cells —
cells that have the potential to differentiate into
other types of cells — exist in adult humans, the most useful
stem cells are those found in embryos, which are pluripotent, capable
of becoming nearly any
cell in the body.
Induced pluripotent
stem cells can be generated from various
types of cells in the body, and they can in turn be coaxed to develop into nearly any
other cell type.
The
stem cells produced through this therapeutic cloning would, like
other embryonic
stem cells, be capable
of developing into many
cell types and serve as a repair system for whatever part
of the body required replenishment at the time.
But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in
other animals, and using
other and less controversial
types of cells — such as
stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.
«But since that leads to increased
cell division and NEUROG1 is used in
other stem cells to make
other types of neurons, scientists in
other fields should be aware that when using this factor, they'll probably also increase
cell proliferation,» Kwan said.
It's a mystery,» he said, suggesting that it could mean
stem cells thought to be committed to a particular lineage may be capable
of becoming
other types of tissue entirely.
Sometimes referred to as the
stem cells of the zebrafish eye, Müller glia are the
cells from which all
other types of retinal
cells are regenerated in the fish.
When the researchers measured gene activity, they found that the iPS
cells were more similar to the ES
cells they descended from than to each
other, suggesting that the source
of the
cells explains many
of the disparities researchers had noted between the two
stem cell types.
Haruko Obokata
of the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, and colleagues at
other Japanese institutions and at Harvard Medical School in Boston reported that simply subjecting blood
cells from newborn mice to a moderately acidic environment for 25 minutes and then tweaking culture conditions could generate pluripotent
stem cells capable
of developing into nearly all
of a body's
cell types.
Although unequal division occurs among
stem cells — allowing one daughter
cell to remain a
stem cell while the
other matures into another
cell type, such as a skin or muscle
cell — the goal
of a normal symmetric
cell division is to generate identical daughter
cells and increase
cell number.
Other research in this area has required that
cells of one
type first be returned to a more generally undifferentiated
stem cell state, which can introduce fresh problems.
Studying mouse embryonic
stem cells, they removed Grb2, a protein essential to the ability
of the
stem cell to transform into
other cell types, from the
cells.
Researchers at the Salk Institute for Biological Studies have, for the first time, taken chimpanzee and bonobo skin
cells and turned them into induced pluripotent
stem cells (iPSCs), a
type of cell that has the ability to form any
other cell or tissue in the body.
Like
other kinds
of stem cells (which can develop into many
other cell types), they can divide repeatedly.
By designing synthetic proteins that can only interact with a pre-determined partner, and introducing them into
cells, the team revealed a key interaction that regulates the ability
of embryonic
stem cells to change into
other cell types.
Praveen Arany at the National Institute
of Dental and Craniofacial Research in Bethesda, Maryland, and his colleagues wondered if they could use lasers and
stem cells to provide a longer - lasting solution, because lasers can make
other tissue
types regenerate.
In contrast with most
other reviews, it covers all major corneal
cell types in a comprehensive way, showing similarities and differences in the healing process and the usage
of stem cells for therapy.
«Those fish sperm
stem cells may be able to become
other types of cells in addition to germ
cells,» he says.
Cancer
cells resemble
stem cells not because they can turn into
other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers
of stop signs and barricades and just keep on multiplying.
The researchers also have yet to determine the specific recipe
of growth factors that would coax
stem cells to create
other types of sensory interneurons.
Studying a new
type of pinhead - size, lab - grown brain made with technology first suggested by three high school students, Johns Hopkins researchers have confirmed a key way in which Zika virus causes microcephaly and
other damage in fetal brains: by infecting specialized
stem cells that build its outer layer, the cortex.
The findings suggested that different
types of blood
cells produce vastly different amounts
of protein per hour, and
stem cells in particular synthesize much less protein than any
other blood - forming
cells.