They also believe that SIRT1 might be important to maintaining the health
of other types of stem cells in the body, which may be linked to overall aging.
hESC researchers George Daley of Children's Hospital Boston and Sean Morrison of the University of Michigan told the panel why research
on other types of stem cells, such as adult stem cells and so - called induced pluripotent stem cells (iPSCs), can't substitute for work on embryonic cells.
«When we've
tested other types of stem cells they haven't been able to fully reverse scarring and lung dysfunction associated with asthma — we've had to combine them with anti-scarring drugs to achieve that.
He added: «Truly naive human ES cell lines would not only help answer fundamental questions about how we are made, and be useful for drug screening and tissue therapy, but they would also provide a benchmark against
which other types of stem cells could be measured in terms of their effectiveness in stem cell therapy and regenerative medicine.»
In the Drosophila testis, however, the whole system has been laid out, and stem cells can be readily identified — a major hurdle for
most other types of stem cells.
«Now that we know a fetus can become tolerant to a foreign stem cell source, we can really think big and consider looking at
how other types of stem cells might be used to treat everything from neurological disorders to muscular disorders before birth,» MacKenzie added.
The group is also testing four
other types of stem cells.
Human embryonic stem cells (hESCs) recently celebrated the 10th anniversary of their discovery, and in the decade since their isolation they have possibly received more press coverage, both over their many potential applications as well as ethical concerns, than
any other type of stem cell.
Other types of stem cells are capable of creating multiple different cell types, but not all the cell types in the body.