In future, other switches could be identified in
other types of tumour cell.
Finally, we hope that the principles presented in this study will also be applicable to
other types of tumours in which we suspect GFI1 to be involved, including brain tumours such as medulloblastomas, the most common and most dangerous type of brain tumour in children.
Not exact matches
«We could get some shrinkage
of the
tumours with
other types of treatment we tried before, but we never got a complete cell kill,» he says.
The researchers found five different sub-
types of HL among the patients studied: 247 cases
of the nodular sclerosis (NS)
type, in which the
tumour nodules are large; 105
of mixed cellularity, where a mixture
of different
types of inflammatory cells are involved; 58 lymphocyte rich, the sub-
type with the best outcome; 68 «
others»; and 143 «not otherwise specified» (NOS).
Cancer stem cells are strongly associated with the growth and recurrence
of all cancers and are especially difficult to eradicate with normal treatment, which also leads to
tumours developing resistance to
other types of therapy.
The research team with international collaborators analysed more than 100 patient samples from ovarian and
other cancer
types to discover a distinct population
of cells found in some
tumours.
The same approach may be useful for boosting the effects
of chemotherapy in
other types of solid
tumour with high levels
of stroma, Ganss says.
The team also found that there were also cases
of other cancer
types in families with these hereditary mutations such as leukemias and brain
tumours.
TNBC is deadly because, unlike
other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast
tumours which have effective targeted therapy, TNBC
tumours do not respond to targeted therapy.
«We showed that there are markers on these stomach
tumour cells that indicate they would be responsive to a
type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment
of melanoma and certain
other cancers.
Analysis
of transcriptomes in
tumour tissues from wild -
type mice and Slc6a14 - null mice indicated no compensatory changes in the expression
of any
other amino acid transporter mRNA.
Some receptors display a broad pattern
of expression across
tumour types, while
others were expressed in cell lines from a particular tissue.
This
type of paralysis may be due to infection, inflammation, degenerative disease, spinal issues,
tumour (won't know if there is anything affecting the brain without CT or MRI), parasites, autoimmune disease (corticosteroids should have helped) among
other causes.