Sentences with phrase «other vaccine trials»

Most other vaccine trials have tried to use the malaria parasite — rather than the body's reaction against it — to find possible targets for vaccines.

Going forward with other vaccine trials, it will be important to know the subclass, specificity and antiviral functions of antibodies that are induced.»

Not exact matches

We talk with two pioneering physicians — one of whom is overseeing the world's largest HIV vaccine trial and the other led a groundbreaking successful pilot in the U.S. — to see how far we are from getting to zero.

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

After years of false starts, a new generation of DNA vaccines and medicines for HIV, influenza and other stubborn illnesses is now in clinical trials

That's because a trial like this one is almost without precedent in modern medical research: It involves giving children a vaccine that is almost certain not to benefit them, and that might harm them, all to protect other children from an unlikely scenario — a large - scale anthrax attack.

The team is now readying the vaccine for human trials and is designing related vaccines to treat other autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.

Tested in a U.S. - sponsored trial that involved more than 16,000 volunteers in Thailand, the vaccine was administered in six injected doses starting in 2006 to half of the group, and the other half received a placebo.

And a new analysis of the stopped STEP trial, published online Monday in Proceedings in the National Academy of Sciences, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development) used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

Other vaccines in trials target the blood - cell stage, and contain a parasite protein called AMA - 1, meant to prime the body's immune system to attack it.

Dr Welaga says that researchers should consider testing the effect of measles vaccines and other routine vaccines on all - cause mortality in randomized trials.

The reliably high percentage of those who develop viremia following exposure to this challenge virus is another advantage — when most or all volunteers develop viremia or other signs of infection, clinical trials can enroll relatively small numbers of people but still achieve answers to such questions as whether a candidate vaccine protects against infection, she noted.

Of more than 50 therapeutic vaccine trials so far, this is the first one that has bolstered the immune system in a «meaningful» way, says Steven Deeks, an HIV / AIDS clinician and researcher at the University of California, San Francisco, who is «cautiously optimistic» that the data will inspire others to study the approach.

Deeks and others believe the trial may have been partly successful because the vaccine contains HIV genes that code for «highly conserved» internal structures and enzymes that can not change much without harming the virus.

Vaccine developers are trying to improve vaccines for transplant recipients and other people with a weak immune system, and the samples used in this study came from a clinical trial of different versions of a flu vaccine in patients on immune - suppressiveVaccine developers are trying to improve vaccines for transplant recipients and other people with a weak immune system, and the samples used in this study came from a clinical trial of different versions of a flu vaccine in patients on immune - suppressivevaccine in patients on immune - suppressive drugs.

If the other trials bear out the Colombian findings or improve on them, the vaccine will be needed in larger quantities.

For this study, the Swiss researchers pooled data with two other groups that conducted Phase 1 trials of the vaccine in Africa — in Lambaréné, Gabon, and Kilifi, Kenya.

«The immune response and the safety so far have put these out there further than the other candidates we have,» says infectious disease specialist Scott Hammer of Columbia University, part of the team designing the VRC vaccine trial.

Negotiations with the U.S. company that holds the license for commercialization of the vaccine — which contains a gene for the Ebola surface protein stitched into a livestock pathogen known as vesicular stomatitis virus (VSV)-- have needlessly delayed the start of the trial, Becker and several other scientists tell Science.

The eagerly awaited results from the world's first large - scale trial of a malaria vaccine are in, and they confirm what other, smaller studies had shown: The vaccine, called RTS, S, offers partial protection, cutting episodes of malaria in babies and toddlers in half.

But more recent research among drug users with HIV in Bangkok has found that half of them carried subtype E, the other half B. Thus, say the trial's critics, Genentech's vaccine is inappropriate for at least half the people in the trial.

HIV Epidemic in Asia: Impilcations for HIV Vaccine and Other Prevention Trials.

Whitehead and the other researchers said that in the case of dengue, the testing was warranted because they knew that the vaccine appeared to be effective at preventing dengue 1, 3 and 4 viruses through previous testing but needed to learn more about its impact on dengue 2 before proceeding to larger trials that could take three to 10 years and cost tens of millions of dollars.

Or if used in a vaccine, they may be most effective in combination with other drugs: a few patients in the small clinical trials whose cancer relapsed after the trials responded to treatment with a checkpoint inhibitor.

While it is not possible to compare antibody levels measured in this trial with those seen in trials of other AMA1 vaccines, based on the relative fold - rise and duration of antibody responses this profile compares favorably with much lower and shorter - lived increases in antibody levels observed in Malian children immunized with AMA1 - C1, an AMA1 vaccine adjuvanted with aluminum hydroxide [19], which provided no measurable protection in a recently reported Phase 2 trial at another site in Mali.

The clinical consortium is led by AFFiRiS itself, and in addition to the PD booster trial, it is now recruiting for a separate Phase I trial of the α - synuclein vaccine against MSA, a synucleinopathy differentiated from PD or LBD based on the cell populations affected, the regional concentration of AS neuropathology, and the spectrum of movement and other symptoms.

Research Trials The HVTN also plans to test other HIV vaccine regimens in Southern Africa in a parallel research track using multiple vaccine candidates.

As in these other trials, most of the adverse reactions both to the malaria vaccine and to the rabies vaccine were local and transient.

His work has led to the development of two potential malaria vaccines, one of which is in clinical trials in the US and the other in preclinical development.

A phase I trial of the H3.3K27M - specific peptide vaccine combined with poly - ICLC for newly diagnosed H3.3K27M - positive diffuse intrinsic pontine glioma (DIPG) and other newly diagnosed H3.3K27M - positive gliomas (NCT02960230).

Several trials of vaccines, given alone or with other therapies, are currently enrolling patients:

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

A phase I trial of the H3.3K27M - specific peptide vaccine combined with poly - ICLC for newly diagnosed H3.3K27M - positive diffuse intrinsic pontine glioma (DIPG) and other newly diagnosed H3.3K27M - positive gliomas -LRB-

Several other planned vaccine trials and research studies that will begin in the coming years will continue to work towards a vaccine that delivers potent protection against HIV.

This year, the network launched a new vaccine trial, close on the heels of three others begun in 2016.

Waisman Biomanufacturing, notes Ross, has a long history of producing experimental vaccines for clinical trials, including for HIV, influenza, hepatitis, herpes and human papillomavirus, among others.

Most recently, CRI has launched a new «venture philanthropy» program called the Cancer Vaccine Acceleration Fund (CVAF) as a means to catalyze development of next - generation therapeutic cancer vaccines and other immunotherapies by helping to address the critical shortage of capital available for early stage clinical trials.

Several trials of vaccines, given alone or with other therapies, are currently enrolling breast cancer patients:

As Head of Project Leader Unit, Nicolas is in charge of the pharmaceutical development and subsequent production of vaccines - for use in clinical trials - directly funded by the European Vaccine Initiative (EVI), and European projects funded from other sources coordinated by EVI.

Dr. Rocke is currently leading a large - scale field trial in 8 western states of the U.S. to determine if oral vaccination through consumption of vaccine - laden baits prevents plague in wild prairie dogs, thus reducing the risk of disease for the endangered black - footed ferret, other animals, and possibly humans.

«Based on the clinical evidence we've gathered over the past decade in our cancer vaccine trials,» Old said, «and in light of data from a variety of trials by others within the field, we believe therapeutic cancer vaccines will increasingly emerge as one of the safest and most powerful ways to combat a variety of cancers.»

In other news, research on a potential vaccine for the Zika virus entered early clinical trials last week.

Four other trials in humans are launching in the upcoming months, and the vaccine has already shown promising results in animals.

But the American and European research communities didn't regard randomized field trials as essential until the 1950s, when Jonas Salk discovered the polio vaccine and Sen. Estes Kefauver held hearings on the testing of thalidomide and other drugs.