Any differences that develop between the two groups of
otherwise identical cells can only be due to the edited gene.
Sheltzer, who began his project in the laboratory of Dr. Angelika Amon at MIT and carried it to conclusion in his own research group at CSHL, placed two sets of
otherwise identical cells in culture dishes, side by side.
They found that here too, the effects of aneuploidy were varied across
otherwise identical cells.
Not exact matches
But in a paper published in the journal
Cell, researchers at the Koch Institute for Integrative Cancer Research at MIT reveal that aneuploidy alone can cause this significant variability in traits, in
otherwise genetically
identical cells.
«We found that these corrected
cells had a normal secretion kinetic when compared with their diseased, parental
cells that are
otherwise genetically
identical except for this single DNA base,» explained lead author Andrew A. Wilson, MD, assistant professor of medicine at Boston University School of Medicine and Director of the Alpha - 1 Center at Bu and BMC.