Sentences with phrase «otherwise normal cells»
But, «a little bit of reactive oxygen in otherwise normal cells is very health - beneficial,» he adds.
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It's possible that inherited regions of CNV with strong influence on gene expression are targeted for amplification / deletion by cancer cells, which might obscure their effect in an otherwise normal cell.
Scientists have known for more than a century that cancer is a disease in which an otherwise normal cell's genes go awry.
Not exact matches
Recent work has also shown that over - or underexpression of certain genes in Arabidopsis plants can prompt embryogenesis in otherwise normal - looking leaf cells.
«We found that these corrected cells had a normal secretion kinetic when compared with their diseased, parental cells that are otherwise genetically identical except for this single DNA base,» explained lead author Andrew A. Wilson, MD, assistant professor of medicine at Boston University School of Medicine and Director of the Alpha - 1 Center at Bu and BMC.
Too much p53 in bone - making cells called osteoblasts dials down a gene, H19, and a related protein, decorin, that would otherwise help stem cells mature (differentiate) to become normal osteoblasts.
In contrast to studies that correlated elevated levels of IGF - 1 with the risk of developing prostate cancer, Greenberg's research showed that eliminating IGF - 1R expression in an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastic.
Autophagy eventually kills cells, so new therapies that deprive cells of nutrients or otherwise thwart metabolism will likely cause more harm to cancer cells than to normal cells.
«This mouse strain is great model for this research because they are otherwise healthy and normal, including in their vision, so it allows us to conduct studies focused on cell integration,» said the publication's lead author, Jie Zhu, PhD, a postdoctoral researcher who started in Lamba's lab three years ago.
Many scientists now believe that — complementing its initial focus on mutated genes — precision oncology must now also address the activity of otherwise normal proteins and molecular pathways that are ultimately responsible for cancer cells» malignant behavior.
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5
Integrative physicians have found that elevated levels of Reverse T3 may an suggest that thyroid hormone is not properly converted from T4 into T3, for use by the cells, and may result in hypothyroidism symptoms despite otherwise «normal» levels of Free T4, Free T3 and / or TSH.
Integrative physicians have found that elevated levels of Reverse T3 may suggest that thyroid hormone is not properly converted from T4 into T3, for use by the cells, and may result in hypothyroidism symptoms despite otherwise «normal» levels of Free T4, Free T3 and / or TSH.
These red blood cell changes can be subtle but important diagnostic clues in an otherwise normal CBC.