Sentences with word «ouabain»
The new and improved ouabain was shown to successfully target sperm - cell proteins in rats, effectively hamstringing their ability to swim, so they couldn't reach and fertilize an egg.
newsweek.com
Thus, ouabain selection enriches the population for CRISPR edits and improves editing efficiency.
NHEJ - or HDR - induced mutations in ATP1A1 can render cells resistant to the small molecule ouabain - and editing at the ATP1A1 locus increases the probability that the locus of interest has also been edited!
Importantly, the point mutations created by Agudelo et al. prevent ouabain binding to ATP1A1 but do not compromise the ion pump's function or cause cellular growth delays.
A few studies have also linked sodium consumption with secretion of a hormone called endogenous ouabain, which exhibits a «vasotonic effect» and causes blood vessels to contract, says Dr. Dolmatova.
This synaptic action results in a prolonged inhibitory synaptic potential which is dependent on metabolism and is selectively blocked by cooling and ouabain.