Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo
out of the nucleus of nerve cells, which protected them from free radicals and structural damage.
Not exact matches
Maybe know all the basic versions, like «cloud brainstorming,» when you write down the
nucleus of an idea and then branch
out to all the potential mini clouds that relate to it.
They're hoping to find
out what controls the size
of the
nucleus, the central compartment
of a cell that contains the DNA, and other components
of the cell as it develops into a many - celled organism.
The new elements, which are all man - made, fill
out the seventh row
of the periodic table, where elements are ranked according to their atomic number - the number
of protons in their
nucleus.
New evidence comes
out to modify the structure
of the atom (from a spherical particle to one
of a
nucleus and electrons orbiting it).
Mark's brief report
of the instructions now becomes the
nucleus of Matthew's second discourse, which, however, begins (10:5) on an exclusively Matthaean note: «These twelve Jesus sent
out, charging them, «Go nowhere among the Gentiles, and enter no town
of the Samaritans, but go rather to the lost sheep
of the house
of Israel.»»
Pagels (1984) points
out that if the relative masses
of protons and neutrons were different by a small fraction
of 1 per cent, making the proton heavier than the neutron, hydrogen atoms would be unstable since the protons that constitute their
nuclei would spontaneously decay into neutrons.
On the other hand, we read here several poems hardly distinguishable from the work
of Second Isaiah; and we must conclude, therefore, that Isaiah 56 - 66 comes
out of continuing Isaianic circles
of prophetism surviving the sixth - century debacle, and had as its
nucleus a small collection
of Second Isaiah's oracles not incorporated in 40 - 55 and perhaps
of somewhat later origin (see especially the three chapters, 60 - 62, and the Servant Song in 61:1 - 4).
DNA never leaves the
nucleus of the cell; its molecular recipes are read
out in the form
of messenger RNA, which leaves the
nucleus and enters the cytoplasm, where proteins are made.
If Comet ISON comes
out the other side, Meech, Li, A'Hearn and countless others around the world will resume their vigil, looking for changes in the shape and composition
of the
nucleus.
To solve this, West proposed «therapeutic cloning» — taking the
nucleus out of a patient's cell, transferring it into an egg cell to create a cloned embryo, then using that embryo to derive patient - matched stem - cell lines.
Instead, they have found that many
of the rays consist
of heavier
nuclei, which curve more — making the job
of figuring
out their origin tougher.
«The argument that the
nucleus is an endosymbiont (given by a number
of authors) is just not borne
out by our knowledge
of the structure and function
of the
nucleus,» concludes Anthony Poole
of Massey University in New Zealand.
The gamma rays knocked neutrons from one
out of every 10 billion gold
nuclei, making these
nuclei so unstable that they decayed to platinum within several days.
The EPR authors described a source, such as a radioactive
nucleus, that shot
out pairs
of particles with the same speed but in opposite directions.
Now, it turns
out that the
nuclei of much lighter elements, such as nickel, can also persist a little longer in their new shape.
To make sure she understood how
nuclei, dendrites, and axons came together to form different types
of brain cells, she pulled
out her crochet hook and went to work.
For instance, ZBTB48 KO (knock -
out) cells loose the expression
of MTFP1 leading to defects in the mitochondrial network with mitochondria clustering around the
nucleus instead
of being widely spread throughout the cell.
Along with black holes, neutron stars are the result
of stars collapsing under gravity once their fuel burns
out, until their density is about the same as that
of the
nucleus of an atom, at which point the protons and electrons «melt» into pure neutrons.
When the gene for a glutamate transporter VGLUT2 was snipped
out of the supramammillary
nucleus, artificial stimulation had no effect on wake and sleep.
As the scientists report today in Nature, about 80 %
of the more than 120 events analyzed turned
out to be light cosmic rays — protons or helium
nuclei.
RNA messages are copies
of small snippets
of DNA that move
out of the cell
nucleus to be converted into proteins.
Measurements
of the space environment round it show that the water flowing
out from the comet's
nucleus forms a prominent atmosphere which interacts with the constant flow
of ionised particles from the sun, the so - called solar wind.
When Gillian Bates at Guy's Hospital, London and Stephen Davies at University College in London and their colleagues examined the brains
of transgenic mice endowed with a DNA encoding 150
of these glutamine repeats, they found that the protein started
out, at birth, in the cytoplasm
of the animals» brain cells and then gradually migrated to cell
nuclei and clumped there.
Very rarely, one
of the projectiles hits a
nucleus head - on and forms a compound
nucleus which flies
out of the foil from the force
of the collision.
Reminded by that
of the Wells novel, Szilard imagined a neutron striking an atomic
nucleus and thus knocking
out two or more neutrons.
Comet Siding Spring's
nucleus — a nugget
of ice and rock measuring no more than half a kilometer (about 1/3 mile)-- is small, but the coma is expansive, stretching
out a million kilometers (more than 600,000 miles) in every direction.
A few years ago, DARPA, which prides itself on promoting far -
out projects, proposed spending $ 30 million on a «hafnium bomb,» a type
of nuclear weapon intended to release energy from atomic
nuclei without either fission or fusion, using an approach similar to how energy is extracted from electrons in a laser.
Normally, the fear response goes from the lateral
nucleus to the central
nucleus and then
out of the amygdala.
In order for the rat to take a step, the stimulus has to go not to the central
nucleus but to the basal
nucleus, and then
out to the parts
of the brain that are involved in active behavior.»
To make Dolly, researchers took the
nucleus out of a mature egg and replaced it with the
nucleus from a cell
of the ewe they wanted to clone; then they activated development with electrical pulses and implanted the embryo into a surrogate mother ewe.
WIMPs should also shove germanium
nuclei out of position, knocking electrons into one another.
«Throughout the irradiated films, we saw individual chains
of defects created by the collisions between the incident ions and
nucleus that broke the perfect atomic order, causing the lattice to locally compress or stretch
out,» said coauthor Lijun Wu, a materials scientist at Brookhaven who led the microscopy work.
Next, Grima looked at cell death in cultured neurons with a healthy or a mutant form
of Huntingtin, or with a mutant form
of Huntingtin that was treated with small amounts
of an experimental drug called KPT - 350, one that prevents a nuclear export protein, Exportin - 1, from shuttling proteins and RNA
out of the
nucleus.
In 2015, Rothstein's team found
out how a mutation in a gene — implicated in 40 percent
of inherited ALS cases and 25 percent
of inherited frontotemporal dementia cases — gums up transport in and
out of the
nucleus in neurons, ultimately shutting the cell down and leading to its death.
The way our genes are arrayed and move in the 3 - D space
of the cell
nucleus turns
out to profoundly influence how they function, in both health and disease
Photons flit in and
out of existence in the lead
nuclei's strong electromagnetic fields.
Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement
of cellular materials in and
out of a cell's control center — the
nucleus — appear to be a direct cause
of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.
Moreover, they suggest, laboratory experiments with drugs designed to clear up these cellular «traffic jams» restored normal transport in and
out of the
nucleus and saved the cells.
Now researchers at the University
of Utah, The Florida State University, University College London and the University
of Sydney in Australia report a way to extend that informational lifetime to more than 100 seconds by encoding an electron's spin onto the much longer - lived spin
of an atomic
nucleus, which can then be read
out electronically.
Problems: sometimes the neutron goes
out and hits a
nucleus of the blanket and instead
of just ringing it like a bell, it goes and one
of the steel atoms absorb [s] the neutron; now this makes it different material, [it] makes it brittle, it makes it radioactive.
Well you -LSB-'ve] got to have this design around it, what's the called blanket; and what the hope is, is that the neutron will go
out and the blanket is made
of some very thick steel - type material, and every so often, a neutron will just hit an atomic
nucleus in the steel blanket and that hit will then make the steel hotter and that hot steel, and then you have, almost like in a car engine, you have some fluid, water could work, going through the steel, it takes the energy away, that water is hot, it goes and spins the turbine, okay that's great.
The signals from
nuclei in a 1 state are 180 degrees
out of phase from those in a 0 state, so can easily be told apart.
However, new research suggests that two
of the most common types
of active galactic
nuclei do, in fact, exhibit fundamental physical differences in the way they consume matter and spit
out energy.
«Our latest research findings support a newly emerging model
of how the brain focuses attention on a particular task, using neurons in the thalamic reticular
nucleus as a switchboard to control the amount
of information the brain receives, limiting and filtering
out sensory information that we don't want to pay attention to,» says senior study investigator and neuroscientist Michael Halassa, MD, PhD.
But on the rare occasions when one does hit a
nucleus of hydrogen or oxygen, the collision can spit
out another subatomic particle, a muon.
RNA was once thought to be a mere middleman, carrying genetic messages from the DNA in the
nucleus out to cellular structures called ribosomes, where it directs the production
of proteins.
Northwestern researchers are analyzing tissue at the nano — as opposed to the micro — scale to root
out cells whose
nuclei have greatly expanded or otherwise show irregularities that could be signs
of impending malignancy.
Systemic lupus erythematosus (SLE) is an immune reaction against material from the body's cellular
nuclei leaking
out of dying cells.
So each type
of fissionable
nucleus gives rise to myriad other
nuclei that spit
out antineutrinos.