Sentences with phrase «outcome results for»

Topline results for bempedoic acid in combination with a high dose statin, expected in September, and outcomes results for PCSK9 and CETP inhibitors, likely in 1H17, are the most notable catalysts over the next 12 months.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

When it's hard to measure business outcomes, marketers use metrics that stand in for those numbers: activity not results, quantity not quality, efficiency not effectiveness.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

The rising support for populism and recent shock outcomes in Britain and the U.S. show nobody can be sure about election results.

Developmental lending as practiced by IBC involves providing financial services (primarily loans) to aboriginal people who, for a variety of cultural and / or financial reasons, are alienated by mainstream lending institutions; approving loan applications on the basis of typical financial considerations while taking into account the potential for positive social or community outcomes; and evaluating social outcomes resulting from the loan portfolio over the long term.

«As a result, the brokers produce worse outcomes for their institutional investor clients — and therefore, for individual pension beneficiaries, mutual fund investors and insurance policy holders — and ill - gotten gains for the brokers,» Macey and Swensen concluded.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

As a result, markets will be watching out for the outcome of the stress tests — due in May — to understand what might happen to Greece this summer: if creditors force Athens to request some additional financial and technical support after August.

HEART APP IMPROVES JOHNS HOPKINS» PATIENT OUTCOMES: A new cardiology - focused iPhone app is reducing readmission rates for heart attack patients, resulting in massive savings, according to a Johns Hopkins University study.

The results focused on the most essential business outcome of all — money — and confirmed that more diversity means more joy for your bottom line.

The resulting cluster effect — interconnected businesses working together in a region — has shown phenomenally positive outcomes for multiple industries, including the medical community.

His method for studying the validity of elections is to compare exit poll results with official election outcomes.

And now that the time for revisionist history has arrived, and strategists no longer have to serve a political agenda and scare investors and traders into voting with their wallets, the research reports calling for precisely the outcome that we expected are coming in fast and furious, starting with none other than Goldman, whose chief strategist David Kostin issued a note overnight in which he says that «the equity market response to the election result will be limited» and adds that «our year - end 2016 price target for the S&P 500 remains 2100, roughly 2 % below the current level of 2140.»

For employees with roles and responsibilities that benefit from cross-functional collaboration, meetings and team discussions allow employees to align project expectations, discuss progress toward goals and resolve inconsistencies in the work, resulting in outcomes that provide the competitive edge that organizations are looking fFor employees with roles and responsibilities that benefit from cross-functional collaboration, meetings and team discussions allow employees to align project expectations, discuss progress toward goals and resolve inconsistencies in the work, resulting in outcomes that provide the competitive edge that organizations are looking forfor.

In the Doug Purvis Memorial Lecture, Governor Stephen S. Poloz shows how changing the mix of monetary and fiscal policies can yield the same outcomes for growth and inflation, but lead to different results for public sector and private sector debt levels, which can impact financial stability.

David Roman of Goldman Sachs Research shares how an Internet of Things - enabled US healthcare system could result in better outcomes for patients and efficiency gains across the healthcare space.

As argued in an earlier piece (Deficit Outcome for 2010 - 11 will be $ 7 billion lower than forecast in October 2010 Update — December 2010: www.3dpolicy.ca), we expect that the deficit in 2010 - 11 will be at least $ 7 billion lower than forecast in the October 2010 Update, based on the financial results to the end of October 2010 and an analysis of the impact of one - time accrual liabilities which inflated the 2009 - 10 deficit oOutcome for 2010 - 11 will be $ 7 billion lower than forecast in October 2010 Update — December 2010: www.3dpolicy.ca), we expect that the deficit in 2010 - 11 will be at least $ 7 billion lower than forecast in the October 2010 Update, based on the financial results to the end of October 2010 and an analysis of the impact of one - time accrual liabilities which inflated the 2009 - 10 deficit outcomeoutcome.

For example, if, as expected, the final audited deficit outcome for 2011 - 12 is lower than that estimated in the March 2012 Budget, some, if not all, of this improvement could carry forward into 2012 - 13, thereby resulting in a lower outcome that currently estimatFor example, if, as expected, the final audited deficit outcome for 2011 - 12 is lower than that estimated in the March 2012 Budget, some, if not all, of this improvement could carry forward into 2012 - 13, thereby resulting in a lower outcome that currently estimatfor 2011 - 12 is lower than that estimated in the March 2012 Budget, some, if not all, of this improvement could carry forward into 2012 - 13, thereby resulting in a lower outcome that currently estimated.

Based on financial results for the first eight months of 2010 - 11 and adjusting for the large extra-ordinary liabilities booked in 2009 - 10, which inflated the deficit outcome for that year, the deficit for 2010 - 11 will be about $ 7 billion lower than forecast in the October 2010 Update.

Applying this improvement to an expected revised deficit outcome of $ 10 billion for 2013 - 14 would result in a surplus of $ 4 billion for 2014 - 15.

Forecasters are generally revising down global growth estimates for 2011 and 2012, mainly as a result of weaker outcomes for the major countries.

However, our hopes for this outcome have recently diminished given tough positions from U.S. negotiators and threatening rhetoric from U.S. President Donald Trump that has resulted in greater uncertainty.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

The March 22nd budget may shed some light on government program spending for 2011 - 12, but we won't know the final spending outcome until the audited financial results for 2011 - 12 are tabled in the fall of 2012.

Volume 1 of the Public Accounts of Canada provides final audited results for the fiscal year just ended, thereby permitting a comparison of the Budget forecast to the actual outcome.

Asked about these matters, Kevin Heine, a Bank of New York Mellon spokesman, said, «We believe an $ 8.5 billion bird - in - the - hand settlement with significant servicing improvements is a far better result for all investors than the likely outcome following years of costly litigation.»

Based on monthly Fiscal Monitor results for 2012 - 13, we argued that the final outcome could be lower than $ 25.9 billion, so this announcement is no surprise.

As a result, it is still too early to assess the potential outcome for this component, although final tax liabilities for 2012 would have to be significantly lower than in 2011 in order to meet the November 2012 Update estimate.

As a result, the brokers produce worse outcomes for their institutional investor clients — and therefore, for individual pension beneficiaries, mutual fund investors and insurance policy holders — and ill - gotten gains for the brokers.

Even in this very simple example, you can see how robotic processes can result in faster and more accurate business outcomes, stronger security and compliance, and higher job satisfaction for workers.

On balance, the final deficit outcome for 2012 - 13, which will not be known until the audited results are released in the fall of 2013, could be slightly lower than the Budget 2013 estimate of $ 25.9 billion.

Awarded to the ETF that has done the most to improve investor opportunities and outcomes in 2017, by providing access to interesting areas of the market, lowering costs, delivering new exposures or otherwise creating better results for investors.

On the eve of the election, and also leading into the results, several of you reached out asking if your portfolios were well - positioned for the election outcome.

To date, Minister Flaherty has been unable or unwilling to explain why the deficit for 2012 - 13 came in so much lower than what he forecast in the March 2013 Budget or why the monthly results to the end of March 2013 were so far off the final outcome for 2012 - 13.

Based on the financial results to date, the final deficit outcome for 2011 - 12 could be at least $ 2 billion lower than forecast in Budget 2012.

Actual results may vary materially from those expressed or implied by forward - looking statements based on a number of factors, including, without limitation: (1) risks related to the consummation of the Merger, including the risks that (a) the Merger may not be consummated within the anticipated time period, or at all, (b) the parties may fail to obtain shareholder approval of the Merger Agreement, (c) the parties may fail to secure the termination or expiration of any waiting period applicable under the HSR Act, (d) other conditions to the consummation of the Merger under the Merger Agreement may not be satisfied, (e) all or part of Arby's financing may not become available, and (f) the significant limitations on remedies contained in the Merger Agreement may limit or entirely prevent BWW from specifically enforcing Arby's obligations under the Merger Agreement or recovering damages for any breach by Arby's; (2) the effects that any termination of the Merger Agreement may have on BWW or its business, including the risks that (a) BWW's stock price may decline significantly if the Merger is not completed, (b) the Merger Agreement may be terminated in circumstances requiring BWW to pay Arby's a termination fee of $ 74 million, or (c) the circumstances of the termination, including the possible imposition of a 12 - month tail period during which the termination fee could be payable upon certain subsequent transactions, may have a chilling effect on alternatives to the Merger; (3) the effects that the announcement or pendency of the Merger may have on BWW and its business, including the risks that as a result (a) BWW's business, operating results or stock price may suffer, (b) BWW's current plans and operations may be disrupted, (c) BWW's ability to retain or recruit key employees may be adversely affected, (d) BWW's business relationships (including, customers, franchisees and suppliers) may be adversely affected, or (e) BWW's management's or employees» attention may be diverted from other important matters; (4) the effect of limitations that the Merger Agreement places on BWW's ability to operate its business, return capital to shareholders or engage in alternative transactions; (5) the nature, cost and outcome of pending and future litigation and other legal proceedings, including any such proceedings related to the Merger and instituted against BWW and others; (6) the risk that the Merger and related transactions may involve unexpected costs, liabilities or delays; (7) other economic, business, competitive, legal, regulatory, and / or tax factors; and (8) other factors described under the heading «Risk Factors» in Part I, Item 1A of BWW's Annual Report on Form 10 - K for the fiscal year ended December 25, 2016, as updated or supplemented by subsequent reports that BWW has filed or files with the SEC.

We regularly assess the likelihood of adverse outcomes resulting from these examinations to determine the adequacy of our provision for income taxes.

Based on the outcome of the corporate results, the SPX is on target to post double - digit earnings growth for the second quarter in a row, the first time in nearly six years.

In short, methodological rigor is critical to ensuring that results of analyses represent possible real outcomes for investors.

# 5 shows where you confirm whether you won or lost your trade - just click the relevant button # 6 shows how many users reported trading the signal # 7 shows how many of those also reported their result # 8 shows the final outcome for all reported results

As this results from a once - off tax policy change, the Bank will abstract from this direct effect of the GST for the purposes of assessing inflation outcomes relative to the target.

Therefore, implementation of a model with strict rules for buying and selling will result in better outcomes.

In fact, for 2011 - 12 the full $ 3 billion adjustment for risk may not be required, resulting in a final deficit outcome of about $ 28 billion.

If the president gets the results he's looking for (whatever they may be) and Beijing is perceived as having played an important role in reaching that outcome, that could give Trump the cover he probably needs to put his pistols back in their holsters and focus on an effective, comprehensive U.S. - China free trade agreement.

As a result, the final deficit outcome for 2010 - 11 could be between $ 3 and $ 6 billion lower - than - estimated in the March 2011 Budget.

«We believe the worst result for ESPR would be success of the remaining CETP inhibitor anacetrapib, as this would be a significant competitor, could set the bar higher for outcomes results, and make the FDA even more likely to require outcomes data for bempedoic acid in our view, because there would be lower unmet need,» the analyst wrote.

The United States has had legislation promoting business owners to adopt ESOPs for more than 30 years, and as a result, there is a robust movement of business including some of the country's largest private companies who wholeheartedly praise the model as leading to better business outcomes.

Even though the outcome of the first vote eliminated candidates from the traditional parties, the results pointed to an eventual victory for independent centrist candidate Emmanuel Macron.

As noted above, the final outcome for budgetary revenues in 2016 - 17 will largely be dependent on what impact tax planning in 2015 - 16 will have on the results for 2016 - 17.