Electron microscopy revealed that the extra hair cells were divided into inner and
outer hair cells, just like the normal ones, and they made the same proteins.
After infection with CMV, these mice developed profound hearing loss and lost a significant amount of
outer hair cells, which are found in the ear and play an important role in hearing.
Sound waves, amplified by
the outer hair cells (shown above right), vibrate the inner hair cells, opening ion channels on their surface that let neurotransmitters flow in.
Compared with a normal mouse cochlea (top), cisplatin exposure reduces the number of
outer hair cells (middle).
While previous vectors have only been able to penetrate the cochlea's inner hair cells, the first Nature Biotechnology study showed that a new synthetic vector, Anc80, safely transferred genes to the hard - to - reach
outer hair cells when introduced into the cochlea (see images).
Post-treatment tests revealed that the gene entered between 30 and 70 percent of hair cells, reaching both inner and
outer hair cells.
Not exact matches
In human
hair shafts, several
outer layers of flattened cuticle
cells surround a layer of cortical
cells (making up the cortex), which surrounds the central core of
cells, called the medulla.
It turns out that keratinocytes, or skin
cells, migrate through the
outer skin to maintain
hair follicles.
The researchers incubate
cells with tiny snippets of single - stranded DNA engineered to slip into the
cells»
outer membranes, covering each
cell like the
hairs on a tennis ball.
Within a
hair follicle, there are stem cells that reside in an area called the hair follicle «bulge,» which is a small compartment located where the outer root sheath meets the arrector pili muscle (see Hair Follicle figu
hair follicle, there are stem
cells that reside in an area called the
hair follicle «bulge,» which is a small compartment located where the outer root sheath meets the arrector pili muscle (see Hair Follicle figu
hair follicle «bulge,» which is a small compartment located where the
outer root sheath meets the arrector pili muscle (see
Hair Follicle figu
Hair Follicle figure).
Morphologically, the DZ in the wild type (WT) is marked by the appearance of epidermal root
hairs on the external surface of
outer cell files (trichoblast) and the existence of fully differentiated xylem for internal
cell files (Dolan et al, 1993; Ishikawa & Evans, 1995; Beemster et al, 2003; Verbelen et al, 2006; Zhang et al, 2010; Mähönen et al, 2014).
Copper is required for hemoglobin production in red blood
cells, production and function of white blood
cells, the absorption, transport and use of iron, energy metabolism, the development, growth and maintenance of bone and connective tissue, the formation and maintenance of myelin sheath (
outer surface of nerve fibers), adrenal hormone production, thyroid hormone production, muscle tone, immunity, reproduction, tissue repair, pigmentation of
hair and skin, and proper growth and development of infants and children.