The progression of retinal dystrophy in the RCS rat is such that by 13 weeks post-graft most of the ONL has disappeared [33] and the photoreceptor
outer segment layer is reduced to a debris zone [40], a finding we observed in dystrophic controls.
Not exact matches
In wild - type, retinal ganglion cell
layer (GCL), inner nuclear
layer (INL), inner plexiform
layer (IPL), and nuclear
layers of rod and cone photoreceptors are distinct, and rod
outer segment (OS) is observed at the
outer-most
layer of the retina.
INL: inner nuclear
layer; IS: inner
segments; ONL:
outer nuclear
layer; RGC: retinal ganglion cell
layer; RPE - L: RPE - like
layer.
Conservation of visual acuity in the iPS - RPE transplanted eyes was associated with the preservation of photoreceptors in the host
outer nuclear
layer (ONL — Fig. 7A), identified by the expression of rhodopsin in the
outer segments of photoreceptors (Fig. 7A inset, Dystrophic + transplant).
(E) Rhodopsin - positive material (red) is present within the cell membrane of human specific marker (HSM)- labelled iPS - RPE (green) 8 days post-transplantation and in the tips of the host
outer segment (OS)
layer.