Not exact matches
Mutations in these genes have been associated with one of the deadliest types of
ovarian cancer,
called clear
cell carcinoma.
Working in
cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug
called fostamatinib combined with the chemotherapy drug paclitaxel may overcome
ovarian cancer cells» resistance to paclitaxel.
In order to find out how and why
ovarian cancer cells grow and take on such lethal characteristics, Dr. Shepherd and his team grow the
cancer cells in 3D structures,
called «spheroids» — the same way the
cancer cells grow in patients.
For the new study, described in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel
Cancer Center and Dana Farber Cancer Institute in Boston collected tissue samples containing normal cells, ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC le
Cancer Center and Dana Farber
Cancer Institute in Boston collected tissue samples containing normal cells, ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC le
Cancer Institute in Boston collected tissue samples containing normal
cells,
ovarian cancers, metastases that had spread elsewhere, and small
cancers found in the fallopian tubes, which included single
cell layers of
cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC le
cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC lesions.
The earliest and one of the most striking came from observations that the presence of infiltrating T
cells (
called «tumor - infiltrating lymphocytes,» or TILs) in
ovarian tumors is positively and strongly associated with improved survival of patients with
ovarian cancer [1].
The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein
called mesothelin — expressed on the surface of such tumors as mesothelioma,
ovarian cancer and pancreatic
cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune
cells.
In 80 percent of women, by the time
ovarian cancer is diagnosed, it has spread to the pad of fat
cells,
called the omentum.
Red foods like red bell peppers and tomatoes contain a phytochemical
called lycopene, which may have an anti-inflammatory affect on the
cells lining the heart and blood vessels, and may reduce the risk of developing prostate
cancer among other
cancers such as breast, lung, bladder,
ovarian, and colon.