For the study, Levine and his colleagues performed genetic analyses of
ovarian cancer cells from 96 patients.
When the researchers tested the circuit in vitro, they found that it was able to detect
ovarian cancer cells from amongst other noncancerous ovarian cells and other cell types.
Not exact matches
The study published in
Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
Cancer Cell shows that exosomes
from tumor
cells of breast
cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
cancer (and other tumor types such as
ovarian and endometrial) are different in size and composition than those of healthy
cells.
Beyond lung
cancer, TiY is able to target TICs in 28 types of human
cell lines derived
from the central nervous system, melanoma, breast, renal,
ovarian, colon, and prostate
cancer.
Analyzing white blood
cells from 934 patients and 1,698 healthy controls, they found BRCA1 methylation among 6.4 % of patients diagnosed with
ovarian cancer, contrasting 4.2 % among controls.
In addition to the afatinib - resistant NSCLC
cells, the researchers tested the neratinib and valproic acid combination on
cell lines derived
from human pancreatic and
ovarian cancers containing K - Ras mutations and N - Ras mutations, respectively.
The researchers then exposed
cells from each of these lines to a panel of 31 different drug treatments — including 23 chemotherapy compounds approved by the FDA for breast and
ovarian cancers, six targeted
cancer drugs, and two common drug combinations.
The research team with international collaborators analysed more than 100 patient samples
from ovarian and other
cancer types to discover a distinct population of
cells found in some tumours.
A section of a tumor organoid grown
from cells derived
from a patient with high - grade serous
ovarian cancer (left) and a mini-tumor treated with ReACp53, resulting in extensive
cancer cell death.
Dr. Vasmatzis» research on the «Quantification of Somatic Chromosomal Rearrangements in Circulating
Cell - free DNA
From Ovarian Cancers» is published in the July 20 edition of Scientific Reports.
In lab experiments, the research team used
cell lines derived
from 40 patient tumour samples to identify that CD151 contributes to the survival of
cells of high - grade serous
ovarian cancer origin.
Analysing certain genes in these
cells enabled them to detect 33 per cent of
ovarian cancers and 81 per cent of endometrial
cancers in Pap test specimens collected
from 627 women already diagnosed with these diseases.
Ongoing Phase 1b / 2 clinical trials combine entinostat with KEYTRUDA ®
from Merck & Co., Inc. for non-small
cell lung
cancer, melanoma and colorectal
cancer; with TECENTRIQ ®
from Genentech, Inc. for triple negative breast
cancer; and with BAVENCIO ®
from Pfizer Inc. and Merck KGaA, Darmstadt, Germany, for
ovarian cancer.
In the proposed project, Dr. Lampi Hermanson will produce NK
cells from stem
cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin
cells, which is expressed in 70 % of
ovarian cancer patients.
The earliest and one of the most striking came
from observations that the presence of infiltrating T
cells (called «tumor - infiltrating lymphocytes,» or TILs) in
ovarian tumors is positively and strongly associated with improved survival of patients with
ovarian cancer [1].
Their theory was first confirmed with
ovarian cancer cell lines and then the Peter / Lengyel team tested HGMA2 protein levels in tumor samples
from 100 patients with
ovarian cancer.
The book introduces the incessant menstruation hypothesis, which may allow physicians to better understand and explain to patients why many serous
ovarian cancers may actually be originating
from the fimbriated end of the fallopian tube and why endometrioid and clear
cell cancers may arise in association with endometriosis.
Surveillance of the tumor mutanome by T
cells during progression
from primary to recurrent
ovarian cancer.
December 17, 2013
Cancer genetics pioneer Janet Rowley, 1925 - 2013 A pioneer in connecting the development of cancer with genetic abnormalities, Janet D. Rowley, MD, the Blum - Riese Distinguished Service Professor of Medicine, Molecular Genetics & Cell Biology and Human Genetics at the University of Chicago, died from complications of ovarian cancer on December, 17, 2013, at her
Cancer genetics pioneer Janet Rowley, 1925 - 2013 A pioneer in connecting the development of
cancer with genetic abnormalities, Janet D. Rowley, MD, the Blum - Riese Distinguished Service Professor of Medicine, Molecular Genetics & Cell Biology and Human Genetics at the University of Chicago, died from complications of ovarian cancer on December, 17, 2013, at her
cancer with genetic abnormalities, Janet D. Rowley, MD, the Blum - Riese Distinguished Service Professor of Medicine, Molecular Genetics &
Cell Biology and Human Genetics at the University of Chicago, died
from complications of
ovarian cancer on December, 17, 2013, at her
cancer on December, 17, 2013, at her home.
Review of «Induced Pluripotent Stem
Cell - Derived Natural Killer
Cells for Treatment of
Ovarian Cancer»
from Stem
Cells by Stuart P. Atkinson
He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in
ovarian cancer, and he is the principal investigator of a multi-million-dollar grant
from the New York State Stem
Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T
cells and hematopoietic stem
cells for generating sustained attack against
ovarian cancer in patients.
Olaparib is a PARP inhibitor, which is already used to treat certain
ovarian cancer patients and prevents damaged
cancer cells from repairing themselves after chemotherapy or radiotherapy.
Their three - dimensional
cell - culture system, adapted for high - throughput screening, has enabled them to identify small molecules that can inhibit adhesion and invasion, preventing
ovarian cancers from spreading to nearby tissues.
October 30, 2011 Fat
cells in abdomen fuel spread of
ovarian cancer A large pad of fat
cells that extends
from the stomach and covers the intestines provides nutrients that promote the spread and growth of
ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011.
A large pad of fat
cells that extends
from the stomach and covers the intestines provides nutrients that promote the spread and growth of
ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011.
The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma,
ovarian cancer and pancreatic
cancer — to a protein
from the tuberculosis bacteria that stimulates the activity of dendritic and other immune
cells.
Using state - of - the - art proteomics and associated computational methods, the Speicher laboratory is investigating protein changes associated with
ovarian cancer, melanoma, cardiac injury resulting
from breast
cancer therapies, ectopic pregnancy, red
cell diseases, and other clinical disorders.
February 10, 2015 New screening tool could speed development of
ovarian cancer drugs University of Chicago Medicine researchers have built a model system that uses multiple
cell types
from patients to rapidly test compounds that could block the early steps in
ovarian cancer metastasis.
University of Chicago Medicine researchers have built a model system that uses multiple
cell types
from patients to rapidly test compounds that could block the early steps in
ovarian cancer metastasis.
Next,
ovarian cancer cells, expressing a fluorescent marker to distinguish them
from the other
cells, were added.
According to the American
Cancer Society, ginger can combat ovarian cancer by blocking the cancer cells from growing, preventing it from spreading and causing more harm to the
Cancer Society, ginger can combat
ovarian cancer by blocking the cancer cells from growing, preventing it from spreading and causing more harm to the
cancer by blocking the
cancer cells from growing, preventing it from spreading and causing more harm to the
cancer cells from growing, preventing it
from spreading and causing more harm to the body.