The researchers found that these immune system pathways were suppressed in a large number of primary tumors — roughly 50 percent of
ovarian cancers studied, 40 percent of colorectal cancers and 30 percent of breast cancers.
The highlights included successful US and European
ovarian cancer studies that underlined the potential of the company's Parsortix liquid biopsy system
This is the first
ovarian cancer study to use a combination of drugs that could be taken orally.
Not exact matches
Several
studies have shown a possible correlation between increased height and increased risk of prostate and
ovarian cancer.
The products are being
studied as treatments for skin
cancer, recurrent
ovarian cancer and high LDL, or bad cholesterol, that doesn't respond to pills such as Lipitor.
Several observational
studies have looked at the link between increased consumption of onions and a reduced risk of certain types of
cancers, including stomach, breast, colon, prostate and
ovarian.
Studies show that the longer a woman breastfeeds the more she reduces the risk of many illnesses to her child (such as childhood
cancers) and risk of illness to herself (lower risk of breast,
ovarian, and cervical
cancer).
Studies also show that there is a decreased incidence of breast and
ovarian cancer and possible decreased risk of osteoporosis.
Limitations in the underlying
studies prevent us from modeling the effect of extended lactation on some maternal conditions (eg,
ovarian cancer).
Recent
studies show that women who breastfeed enjoy decreased risks of breast and
ovarian cancer, anemia, and osteoporosis.
Studies show that women who have breastfed experience reduced rates of breast and
ovarian cancer later in life.
• According to
studies, there is a link between breastfeeding and a lower incidence of several diseases in women, including Type 2 diabetes,
ovarian cancer and breast
cancer.
Reduced Risk of Some
Cancers Studies have found the longer a mom breastfeeds, the more they are protected against breast and
ovarian cancer.
Earlier
studies have shown that mothers who nurse their babies exhibit lower risk of breast and
ovarian cancers.
And
studies show that breastfeeding helps lower a woman's risk of breast
cancer, high blood pressure, diabetes, and cardiovascular disease, and also may help decrease the risk of uterine and
ovarian cancer.
Background: Epidemiologic
studies have yielded inconsistent findings between breastfeeding and epithelial
ovarian cancer (EOC) risk.
Some
studies have shown that breastfeeding reduces a woman's chance of breast and
ovarian cancer later in life.
Some
studies suggest it may help prevent bone loss later in life and possibly lower the risk of
ovarian cancer by delaying the onset of menstruation after pregnancy.
«Nonetheless, the proof of concept
studies we have obtained thus far are extremely encouraging, and we are confident that with proper support and efforts we could translate our findings into experimental therapeutics for a variety of solid tumors that are driven by EphA2 overexpression, including breast, lung, prostate, pancreatic, and
ovarian cancers,» said Pellecchia, who serves as the founding director of the Center for Molecular and Translational Medicine at UCR.
«Experimental drug combined with standard chemo may shrink treatment - resistant
ovarian cancers, animal
study shows.»
Based on results of the current
study described in a report online June 18 in the journal
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian c
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced
ovarian cancercancer.
Chemotherapy drugs designed to kill tumors may actually encourage
ovarian cancer by stimulating the growth of cells that give rise to the malignancy, a new
study finds.
«Because there is currently no reliable screening available for
ovarian cancer, most cases are diagnosed at advanced stages,» said the study's author, Bo (Bonnie) Qin, PhD, a postdoctoral associate at Rutgers Cancer Institute of New J
cancer, most cases are diagnosed at advanced stages,» said the
study's author, Bo (Bonnie) Qin, PhD, a postdoctoral associate at Rutgers
Cancer Institute of New J
Cancer Institute of New Jersey.
But this situation may soon change if researchers can extend the promise of a recent
study, in which scientists detected
ovarian cancer from blood samples with near 100 percent accuracy.
The
study published in
Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
Cancer Cell shows that exosomes from tumor cells of breast
cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
cancer (and other tumor types such as
ovarian and endometrial) are different in size and composition than those of healthy cells.
To identify the relevant mutations the scientists analyzed the blood samples of 1,858 men from three independent cohorts in Europe and North America: the Swiss arm of the European Randomized
Study for Prostate
Cancer Screening, the large American Screening trial, Prostate, Lung, Colorectal, and
Ovarian (PLCO), Princess Margaret
Cancer Centre (University Health Network) and Mount Sinai Hospital (Sinai Health System) in Toronto.
Qin said that among all African - American women in the
study, those with the highest adherence to an AHEI - 2010 diet were 34 percent less likely to be diagnosed with
ovarian cancer than women with the lowest AHEI - 2010 adherence.
In order to assess whether an improved diet could reduce the risk of
ovarian cancer in African - American women, Qin analyzed the diets of 415 women with ovarian cancer and 629 control patients, using data from the African - American Cancer Epidemiology Study, a population - based case - control study of ovarian cancer in African - American women in 11 sites in the United S
cancer in African - American women, Qin analyzed the diets of 415 women with
ovarian cancer and 629 control patients, using data from the African - American Cancer Epidemiology Study, a population - based case - control study of ovarian cancer in African - American women in 11 sites in the United S
cancer and 629 control patients, using data from the African - American
Cancer Epidemiology Study, a population - based case - control study of ovarian cancer in African - American women in 11 sites in the United S
Cancer Epidemiology
Study, a population - based case - control study of ovarian cancer in African - American women in 11 sites in the United St
Study, a population - based case - control
study of ovarian cancer in African - American women in 11 sites in the United St
study of
ovarian cancer in African - American women in 11 sites in the United S
cancer in African - American women in 11 sites in the United States.
But Weidhaas and Slack's
studies showed how the KRAS - variant increases a woman's risk of
ovarian cancer — more than 27 percent of women with this type of
cancer carried the variant.
Martin Matzuk, an endocrinologist at Baylor College of Medicine in Houston, began
studying FSH for another reason: to investigate the hormone's role in
ovarian cancer.
Another
study, conducted by Barbara Weber and her colleagues at the University of Pennsylvania, screened 263 breast
cancer patients for BRCA1 mutations and asked them about their family history of breast and
ovarian cancers.
Razqallah Hakem, a
cancer biologist at the University of Toronto in Ontario, and his colleagues normally
study a tumor suppressor called BRCA1, variants of which put women at high risk of breast and
ovarian cancer.
Funding for the
study was provided by the National Institutes of Health (P50 CA083638, R21 CA156224, 5P30 CA016520 - 36), the Marcus Foundation, the
Ovarian Cancer Immunotherapy Initiative, the Ludwig Institute for
Cancer Research at the University of Lausanne, and the Ovacure Foundation.
The
study, which compared each model's success in Caucasian women with those of Asian descent (Chinese, Japanese, Filipino, Korean and Vietnamese), also raised important questions about the effect of race on
cancer development: When Caucasian and Asian patients with similar family histories of breast and
ovarian cancer were compared, the Asian women had higher rates of genetic mutation, although the rates of these
cancers for Asians have traditionally been lower.
«Women who carry a mutation in BRCA genes have an increased risk of developing breast and
ovarian cancer,» Kristy A. Brown, Ph.D.,
study principal investigator, said.
A
study involving Ottawa and Taiwan researchers, published in the journal Proceedings of the National Academy of Sciences (PNAS), provides new insight into why
ovarian cancer is often resistant to chemotherapy, as well as a potential way to improve its diagnosis and treatment.
«This
study provided encouraging preliminary results for the use of RT in women with
ovarian cancer.»
And that's when
ovarian cancer becomes deadly,» says
study author J. Rebecca Liu, M.D., associate professor of obstetrics and gynecology at the University of Michigan.
The
study evaluated 56 patients with
ovarian clear cell adenocarcinoma (CCA), an aggressive form of
ovarian cancer that is more likely to be resistant to chemotherapy and to have a poorer prognosis than other forms of this disease.
The team's recent
study in mice has found that the treatment reduced the mass of
ovarian cancer tumors and was more effective at suppressing tumor growth than chemotherapy.
TRINOVA - 2 is evaluating pegylated liposomal doxorubicin in combination with either placebo or trebananib in previously treated patients with
ovarian cancer while TRINOVA - 3, also known as ENGOT - Ov2 and Gynecologic Oncology Group — 3001, is
studying the use of trebananib in front - line treatment adding it to carboplatin / paclitaxel.
«This
study also adds greater understanding of tumor - infiltrating lymphocytes and their influence on the causes and progression of
ovarian cancer.
Heeke says the
study would be open to people whose tumors have evidence of HRD like those found in this
study, which includes bladder, breast, cervix, liver and bile duct, colorectal, endometrial, gastric / esophageal, head & neck, kidney, neuroendocrine, lung,
ovarian, pancreas, prostate, sarcoma, and thyroid
cancers, as well as gastrointestinal stromal tumors, glioma, melanoma and unknown primary
cancers.
Diamond is also quick to point out that while the current
study shows that COXEN could have been used to predict the most useful drug in many of these cases of advanced
ovarian cancer, the actual use of the model will be possible only after validation with a prospective clinical trial.
This is the largest
study of its kind to use new technology to comprehensively investigate the inherited basis of
ovarian cancer.
«This
study supports the idea that we could test
ovarian cancer tumors and say they're more likely to respond to one or the other drugs,» Diamond says.
The role of weight in
ovarian -
cancer risk emerges from an analysis of data on some 68,000 women participating in one of three major ongoing investigations: the New York (City) University Women's Health Study, the Northern Sweden Health and Disease Study in Umea, and the Diet in the Etiology of Breast Cancer Study in Milan,
cancer risk emerges from an analysis of data on some 68,000 women participating in one of three major ongoing investigations: the New York (City) University Women's Health
Study, the Northern Sweden Health and Disease
Study in Umea, and the Diet in the Etiology of Breast
Cancer Study in Milan,
Cancer Study in Milan, Italy.
Acknowledging that «this is not a big
study, in terms of the overall number of cases, for
ovarian cancer it's a very big study,» explains Annekatrin Lukanova of the International Agency for Cancer Research in Lyon, F
cancer it's a very big
study,» explains Annekatrin Lukanova of the International Agency for
Cancer Research in Lyon, F
Cancer Research in Lyon, France.
Where mutations occur in two important
cancer genes can affect a woman's risk of breast or
ovarian cancer, a
study of thousands of women shows.
To capture uncommon genetic variants, the
study used an exome genotyping array to genotype 7,060 epithelial
ovarian cancer (EOC) cases and 6,712 cancer - free women from the Ovarian Cancer Association Cons
ovarian cancer (EOC) cases and 6,712 cancer - free women from the Ovarian Cancer Association Conso
cancer (EOC) cases and 6,712
cancer - free women from the Ovarian Cancer Association Conso
cancer - free women from the
Ovarian Cancer Association Cons
Ovarian Cancer Association Conso
Cancer Association Consortium.