The Colorado lab discovered that
granulosa cells — the cells that surround maturing eggs in the
ovarian follicles — were pumping out leptin and shipping it into the egg.
If you believe, for example, that
granulosa cells and other very early features of
ovarian ecology set up the polarities that ultimately determine the quality of a human egg, as Albertini does, then certain techniques widely used in IVF may be subtly perturbing the very mechanisms that eggs use to establish a plan to build an embryo and maximize the chances that it will develop properly.