In her latest discovery, she has found that during the menstrual cycle,
ovarian hormones act like a master conductor — they turn genetic risk on and off in the body.
Furthermore, high blood levels of insulin can
act by increasing androgenous hormonal stimulation of the
ovarian theca cells as well as potentiating gonadotropin - stimulated
ovarian androgen steroidogenesis — although recent data has suggested that the insulin - induced increase in
ovarian hormone secretion is not accompanied by increased steroid metabolism.74 Hyperinsulinaemia may also affect the central actions of androgen by impairing progesterone inhibition of the gonadotropin - releasing
hormone pulse generator.75 Insulin has also been shown to increase expression of adrenal steroidogenic enzyme mRNA47 as well as adrenal responsiveness to adrenocorticotropic
hormone.76