"Ovarian tumors" refers to abnormal growths or lumps that develop in the ovaries, which are part of the female reproductive system. These tumors can be either cancerous (malignant) or non-cancerous (benign).
Full definition
And although most tumors in horses occur as they get older, this is not the case
with ovarian tumors as these commonly occur in horses 5 to 9 years of age.
He previously revealed the existence of spontaneous immune responses in
ovarian tumors as well as described how regulatory T cells and tumor blood vessels affect these responses.
Researchers have devised a new test to help doctors
diagnose ovarian tumors and choose the most appropriate treatment.
As proof - of - principle of the potential efficacy, Zhang's team grew human
ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.
The researchers have devised a nanosensor that breaks apart in the presence of
ovarian tumor cells and sheds fragments of itself.
Research Interests: Mechanisms of immune regulation in the breast and ovarian tumor microenvironment
The researchers show that killer T cells isolated
from ovarian tumors using their method are much better at both recognizing neoepitopes than are those isolated from blood.
Weisman said it should be possible to noninvasively find small
ovarian tumors within rodents used for medical research by linking nanotubes to antibody biomarkers and administering the biomarkers intravenously.
As proof - of - principle of the potential efficacy, Zhang's team grew
human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference againstFAL1.
The work coming out of the molecular therapeutic laboratory directed by Richard G. Moore, MD, entitled «HE4 (WFDC2) gene overexpression
promotes ovarian tumor growth» was recently published in the international science journal Scientific Reports, a Nature publishing group.
But mutations, which are found in 96 percent of patients with high - grade
serous ovarian tumors, can cause p53 to form clumps, or «aggregates,» which impair the protein's normal function.
One study showed that
ovarian tumors produce a signaling molecule that serves to attract regulatory T cells, a subclass of adaptive immune cells responsible for quieting other T cells.
In their most intriguing work, they're collaborating on something new: a «theranostic» nanoparticle that can both diagnose and
attack ovarian tumors.
Hammond has ongoing investigations with both of those labs, work that could lead to a theranostic nanoparticle that simultaneously
identifies ovarian tumors and hits them hard.
«I might expect to see a 25 -
pound ovarian tumor, but a 132 - pound tumor is very rare,» said lead surgeon Vaagn Andikyan, MD, a gynecologic oncologist at Danbury Hospital, in a statement.
A study of Chinese women published in the «American Journal of Clinical Nutrition» found that mothers who breastfed their babies past the age of 13 months were at a much lower risk of
developing ovarian tumors than those mothers who breastfed for shorter periods.
Breast, uterine, and
ovarian tumors often use these receptors to boost their growth, and many cancer drugs target them.
«We found a striking difference between the metabolic profiles of poorly aggressive and highly
aggressive ovarian tumor cells, particularly with respect to their production and use of the amino acid glutamine,» said lead researcher Deepak Nagrath of Rice.
Scientists identified the specific proteins secreted by the parasite Toxoplasma gondii that cause the immune system in mice to attack
established ovarian tumors.
This new approach to
classifying ovarian tumors can help doctors make the right management decisions, which will improve the outcome for women with cancer.
«New imaging technique could identify
additional ovarian tumors not visible to surgeons» eyes: Amount of residual tumor left after surgery is an important prognostic factor for ovarian cancer patient survival.»
Now, MIT engineers have developed a far more sensitive way to
reveal ovarian tumors: In tests in mice, they were able to detect tumors composed of nodules smaller than 2 millimeters in diameter.
«New technology can detect
tiny ovarian tumors: «Synthetic biomarkers» could be used to diagnose ovarian cancer months earlier than now possible.»
Now, results of a study of nine women suggest that the genomic roots of
many ovarian tumors may indeed arise in the fallopian tubes, potentially providing insights into the origin of ovarian cancer and suggesting new ways for prevention and intervention of this disease.
By analyzing patterns of gene expression, researchers
sorted ovarian tumors into two types that correlated with how long patients survived.
Harari, Coukos and their colleagues report in Nature Communications that, despite their low mutational load,
epithelial ovarian tumors are infiltrated with T cells that are especially good at recognizing and killing cancer cells.
And a December 2014 study found that
ovarian tumors coax adult stem cells into providing key metabolites they need to grow.
Among these and other results integrating multiple platforms, it's apparent that Basal subtype tumors more closely
resemble ovarian tumors than other breast cancer subtypes.
iPSC - NKs themselves have already shown efficacy in the battle against leukemia and HIV infection [4, 5] and so researchers from the laboratory of Dan S. Kaufman (University of Minnesota, USA) aimed to assess their anti-tumorigenic capabilities
against ovarian tumors [6].
In
Penn ovarian tumors, the levels of immune molecules like CD3, CD8, FoxP3, and PRF1 were found at significantly lower levels with PTEN loss.
This means things
like ovarian tumors and Cushing's disease have the potential to cause similar symptoms.
Earlier this year, a team of doctors in Connecticut removed an 132 - pound
mucinous ovarian tumor from a 38 - year - old woman — one of the largest operations on record of this type of tumor.
Rare types of
ovarian tumor include the teratoma formed by embryonic germ (primitive) cells that develop abnormally to produce many different tissues.
Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice
with ovarian tumors.