Nanog and Sox2 are among the enzymes used by researchers to generate iPSCs, therefore ZFP217 may represent another tool needed to achieve tight control
over cell reprogramming.
Not exact matches
Ding's team took
cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the
reprogramming proteins for 36 hours, and repeated this cycle four times
over.
But just how close adult and
reprogrammed stem
cells can come to matching the capabilities of embryonic stem
cells has become a contentious question in the debate
over whether the federal government should continue funding research on embryonic lines.
We now know that this explains the different behaviour of male and female
cells after
reprogramming because,
over time, female
cells lose one of the two X chromosomes and start behaving more or less like male iPS
cells.»
When the stress is
over,
cells must rapidly
reprogram their metabolism and restart growth and division.
The idea is to introduce a biodegradable scaffold under the skin that temporarily creates an «infection - mimicking microenvironment,» capable of attracting, housing, and
reprogramming millions of dendritic
cells over a period of several weeks.
He adds that the stem
cells used in the study have advantages
over reprogrammed skin
cells, including eliminating the tricky business of inducing the
cells to become muscle
cells, but he notes that both types of
cells could pose risks because the virus used to modify them could cause cancer.
There are studies on embryonic stem
cells, which can make all the tissues of your body, and people
over the past couple years have been able to take a set of genes and put them in and
reprogram the skin
cells to think they're an embryonic
cell and therefore being able to make all the tissues of your body.
Generally,
reprogramming occurs
over many days in most
cell types, and it seems that fewer factors are introduced, longer time is required for
reprogramming to occur [15].