Sentences with phrase «over the study duration»

«MRI - PDFF, and magnetic resonance elastography (a non-invasive imaging technique that measures the stiffness of soft tissues) proved to be accurate, quantitative, and useful over the study duration in measuring the state and progression of disease.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In fact, a recent study in the Journal of the American Medical Association, the Association Between Duration of Breastfeeding and Adult Intelligence, showed an over 6 point increase in IQ between babies that breastfed for less than a month and those that breastfed for at least 7 to 9 months.

Another study had been conducted by Yvonne et al. to assess the impact of the distribution of educational booklets during the postnatal period, but this time over the duration of complete breastfeeding, and the result was an insignificant difference noted for the duration of breastfeeding between the study group and the control group [21].

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

While the researchers did not directly compare survival rates and neurological outcomes with whether individual patients received bystander CPR or defibrillation, they did find increases in both over the duration of the study.

The intensification of winter storm activity in Alaska and Northwestern Canada started close to 300 years ago and is unprecedented in magnitude and duration over the past millennium, according to a new study from Dartmouth College.

However, Schellenberg and von Scheve believe that the steady increase in duration and decrease in tempo that they found in their study doesn't support the idea of growing difficulties fully because it would mean our problems have increased steadily over the last fifty years.

Although this may be bad news for the Baltic Sea and other areas plagued by this dinoflagellate, Kremp also noted that the short duration of most lab studies limits what we can know about how toxic algae may evolve over the next century.

The scientists used the following arrangement for their experiments: Over a period of ten minutes, 41 participants in the study were given painful heat stimuli to the hand which varied in intensity throughout the duration of the experiment.

However, a higher number of studies looked at indirect comparisons and in those cases tetracycline appeared to have larger benefits than doxycycline, norfloxacin and trimethoprim - sulfamethoxazole, while single dose azithromycin shortened the duration of diarrhea by over a day compared to ciprofloxacin and by half a day compared to erythromycin.

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

This is the first study to show that sleep duration has increased among broad segments of the United States population (students 15 and older, people who are employed, and retirees) over this period.

The type and duration of sun exposure, number and severity of phototoxic reactions, and adverse events were recorded over the study periods.

«For various periods over the last 60 years, we have been able to combine important processes: atmospheric variability, such as the North Atlantic Oscillation, water and air temperatures, the occurrence of fresh surface water, and the duration of convection,» explains Dr. Marilena Oltmanns from GEOMAR, lead author of the study.

Heart rate and blood pressure were recorded before administration of placebo or MP and periodically over the duration of the study.

individual would be 1.47 mg / kg, but our pharmacokinetic study indicated that in macaques, a dose of 5 mg / kg is to achieve MIC levels in blood for over 80 % of the treatment duration of 12 hours.

When considered over the duration of the OCTO study the inversion occurred in a high percentage (32 %) of the individuals included in the original sample and was associated with non-survival.

The longitudinal study analyzed the association of aspirin, with varied doses and duration of use, on overall mortality risks and mortality risks from cancer over a nearly 32 - year period.

Over the 3 - year duration of the study, some of the participants who hadn't been diagnosed with Huntington's disease at the beginning of the study have now developed symptoms of the disease.

STUDY OPTIONS: This course runs for 12 months over three terms, each 13 weeks in duration.

Studies have shown that getting consistent exercise over time actually helps improve sleep efficiency and sleep duration for young and old people alike.

Over the duration of the present study, no adverse effects were noted.

Over the course of the first eight weeks, infant vitamin D levels declined substantially, after which they remained constant for the duration of the study.

In fact, a study of Ikarian men (who are known to live to be well over a hundred), found that among men aged 65 — 100, 80 % of them claimed to have sex regularly, and a quarter of that self - reported group said they were doing so with «good duration» and «achievement.»

According to this graph, rats fed an amount of protein that Harlan and the scientific community in general consider adequate (18 %) grow from 50 grams to over 100 grams during the course of time corresponding to the duration of Campbell's study, indicated by the large red bracket.

According to most studies — and depending on the duration and intensity of your workout — you can expect to burn an additional 50 - 150 calories over the next 24 hours as a result of your workout.

Another study by Pubmed showed that when infertile men were given 6g of tribulus terrestris extract for 60 days, their erections were able to improve over the duration.

Additionally, studies have found that we will naturally eat less over the following few days to make up the calorie balance.1, 2 Among individuals who maintain a stable body weight, meal - to - meal caloric intake might vary somewhat but the general trend over a longer duration remains at a stable level.

Over the duration of the last academic year I have been studying this theory, using learning observations, meetings with teachers, student voice, book looks and learning walks (supportive strolls) as sources of information from which I could hopefully draw some conclusions.

if we were not in a strong bull market over much of the duration of the study.

The duration and strength of hurricanes have increased by about 50 percent over the last three decades, according to study author Kerry Emanuel, a professor of atmospheric science at the Massachusetts Institute of Technology in Cambridge.

Last year, Emanuel published a study correlating the documented increase in hurricane duration and intensity in the Atlantic and Pacific oceans since the 1970s to rises in sea surface temperatures over the same time period.

The study involved over 29,000 adults, making it the largest study to assess the relationship between sleep duration and the presence of metabolic syndrome.

Firstly, the study was done over a longer time period (median duration of risperidone treatment was 1 y) than is usually the case in trials of atypical antipsychotics.

None of the variables we measured significantly predicted changes in positive affect over time, which may be due to the short duration of the study.

In Study 2, a daily experience study of 101 established couples (N = 202) with a 3 - month follow - up, day - to - day changes in post sex affection duration and quality were associated with both partners» sexual and relationship satisfaction, and engaging in longer and more satisfying post sex affection over the course of the study was associated with higher relationship and sexual satisfaction 3 months lStudy 2, a daily experience study of 101 established couples (N = 202) with a 3 - month follow - up, day - to - day changes in post sex affection duration and quality were associated with both partners» sexual and relationship satisfaction, and engaging in longer and more satisfying post sex affection over the course of the study was associated with higher relationship and sexual satisfaction 3 months lstudy of 101 established couples (N = 202) with a 3 - month follow - up, day - to - day changes in post sex affection duration and quality were associated with both partners» sexual and relationship satisfaction, and engaging in longer and more satisfying post sex affection over the course of the study was associated with higher relationship and sexual satisfaction 3 months lstudy was associated with higher relationship and sexual satisfaction 3 months later.

Again, our model explained significant variance and was a good fit to the data in CARDIA for year 15 blood pressure, as well as for increases in blood pressure over the 15 - year duration of the study.

Our finding that the severity of depressive symptoms was a significant but relatively smaller contributor to physical disability in this sample (after controlling for the possible effects of age, sex and duration of pain) is consistent with findings of some previous studies of patients with chronic pain, but not with some treatment studies, which found that depression level contributed to less significant improvement in pain - related disability.11, 27 It is not surprising that cognitive, pain and behavioural variables accounted for more physical disability than depressive symptoms but it is notable that social support (as measured by the MPI), sense of control over life, and catastrophising did not significantly contribute to physical disability.

Our finding that the severity of depressive symptoms in our sample of patients with chronic pain was best correlated with a combination of heightened catastrophising, reduced sense of control over life, increased physical disability, lower pain self - efficacy beliefs, higher use of unhelpful self - management strategies, and lower perceived social support (after controlling for the possible effects of age, sex and duration of pain) is consistent with previous studies of patients with chronic pain.26 Interestingly, and somewhat contrary to clinical expectations, pain severity, pain - related distress, and fear of movement / (re) injury were not significantly associated with depressive symptom severity.

Property taxes make up about one quarter of home ownership costs over the median duration of ownership, according to a study by two researchers with the Urban - Brookings Tax Policy Center.