Sentences with word «overactivation»

Both are rooted in overactivation of the control system for hormones (hypothalamic - pituitary - adrenal axis), often triggered by stress, in this case, having a baby.

«This study is the first demonstration that the receptor TREML4 amplifies the cellular responses transmitted through the TLR7 receptor and that a lack of such amplification prevents the inflammatory overactivation underlying lupus,» says Terry Means, PhD, of the Center for Immunology and Inflammatory Diseases in the MGH Division of Rheumatology, Allergy, and Immunology.

Means notes that identifying the potential role of TREML4 in human lupus may lead to the development of drugs that could prevent or reduce the development or progression of lupus and another autoimmune disorder called Sjögren's syndrome, which also appears to involve TLR7 overactivation.

While IL - 18 is useful for protecting the body against external pathogens, too much of this protein leads to a harmful overactivation of the immune system, resulting in the various symptoms presented in patients.

FOP is caused by overactivation of a signaling protein involved in embryo development, BMP.

Consistently, we observed nuclear localization of β - catenin in the more - lateral mesoderm only, and β - catenin overactivation converted the mesodermal midline toward a more lateral fate and position (fig.

There can be a risk, however, involved with constant overactivation of inflammatory processes.

We hypothesized that participants with higher anxiety would have a different pattern of activation during negative emotion processing because, in behavioral studies, it was found that anxious subjects displayed hypervigilance in response to cues related to attachment threat or a prolonged overactivation of the attachment system.

So, like age - related overactivation generally, this age - related alteration in hemispheric specialization, a pattern dubbed «hemispheric asymmetry reduction in older adults» or HAROLD (Cabeza, 2002), means that cognitive neuroscience studies of brain aging are raising new questions with broad neuroscientific implications (Figure 1A).

Although the majority of research attention to the hypothalamic — pituitary — adrenal (HPA) axis in stress - related disorders and as a marker of allostatic load has focused on overactivation of this stress system, theory and data clearly indicate that underactivation is also an important type of dysregulation.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

Overactivation of AIM2 has been linked to disorders including psoriasis, an abdominal aortic aneurysm and lupus.

Overactivation of this pathway, which most likely evolved to detect the presence of disease - bearing insects on the skin, results in increased scratching akin to that seen in patients who develop chronic itch.

They discovered that overactivation of this pathway, which is observed in some types of cancer such as renal cell carcinoma, melanoma and pancreatic cancer, is important to promote and support the growth of cancer cells in culture and animal models.

These inhibitors can also bind to and inhibit the mutated factor XII, but this is not enough to completely stop the overactivation.

«We now believe that DT104's enhanced invasive ability is the result of an overactivation of invasion genes while within the challenging environment inside the protozoa,» says Carlson.

Inflammation, or the overactivation of the immune system, appears to be involved in both.

Memantine is an NMDA receptor antagonist, aimed at counteracting the overactivation of the receptor caused by the mutation.