Sentences with phrase «overcoming drug resistance»
Importantly, while not a cure, adding a second targeted therapy could help improve treatments by overcoming drug resistance and extending the time before the cancer returns.
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These drugs can hit cancer harder than those targeting only one protein, and look promising for preventing or overcoming drug resistance.
«Diabetes drug points the way to overcoming drug resistance in melanoma.»
Yeh said the findings could be one weapon to fight what has become a major public health risk, but overcoming drug resistance will require a full arsenal.
«Molecular decoys help overcome drug resistance.»
«Targeted nanoparticles can overcome drug resistance in trypanosomes: A high - tech approach to combat sleeping sickness and potentially other neglected diseases.»
The researchers say their method offers a new explanation for how to prevent cancer cells from becoming treatment - resistant and how combinations therapies can be developed to overcome drug resistance.
«This study demonstrates how classic antibiotics derived from natural products can be redesigned to create semi-synthetic compounds to overcome drug resistance,» said corresponding author Richard Lee, Ph.D., a member of the St. Jude Department of Chemical Biology and Therapeutics.
Researchers developed the strategy as a way to develop inhibitors of «undruggable» proteins and overcome drug resistance, a common shortcoming of targeted therapies.
Men with aggressive prostate cancer that has stopped responding to conventional treatment could potentially benefit from a new class of cancer drug designed to overcome drug resistance, a new study suggests.
C. Develop ways to overcome cancer's resistance to therapy Identify therapeutic targets to overcome drug resistance through studies that determine the mechanisms that lead cancer cells to become resistant to previously effective treatments.
New treatment strategies to overcome drug resistance in chronic myelogenous leukemia and other cancers will come from the detailed structure of the enzyme Abl.
Paradox Pharmaceuticals Inc. of Memphis, Tennessee: chemotherapeutic agent for use in companion animals to overcome drug resistance.
Not exact matches
Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells» resistance to paclitaxel.
«Understanding how drug resistance develops can help in the design of new agents or strategies to overcome resistance,» says principal investigator Sameek Roychowdhury, MD, PhD, assistant professor of medicine and of pharmacology in the Division of Medical Oncology at the OSUCCC — James.
«Blocking autophagy with malaria drug may help overcome resistance to BRAF drugs in melanoma.»
The study results also suggest that the drug combination can delay or overcome resistance to fulvestrant.
A new study led by University of Kentucky researchers suggests a new approach to develop highly - potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.
«Furthermore, they demonstrate that a new chemical class binds to an alternative site on the enzyme, which overcomes existing drug resistance and opens up the exciting possibility for development of a novel class of anti-TB drugs.»
Groundbreaking findings, published online in the journal journal Cancer Cell, show that resistance to many types of antibody drugs can be overcome by preventing cancer cells from «hiding» from immune cells.
In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI - 110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.
St. Jude Children's Research Hospital scientists have discovered a promising new class of antibiotics that could aid efforts to overcome drug - resistance in tuberculosis (TB), a global killer.
If so, the changes would provide yet another way to overcome resistance to various drugs.
«Understanding the differences among lung cancers also could lead to innovations in treatment strategies and allow us to overcome drug - resistance, relapse and disease progression.»
«The quicker we can learn about drug resistance, the faster we can overcome it,» said Oxnard.
By adding a second experimental drug that blocks this alternative survival route by targeting a protein called FAK, the researchers discovered that resistance to BRAF inhibitors can be overcome.
A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.
But these epigenetic drugs have shown some success in improving patients» response to chemotherapy or immunotherapy, or in overcoming resistance to those standard treatments.
«We wanted to find out if combining ARTs with anti-cancer drugs would overcome resistance.
The evidence may explain why the disease is so persistent, the Johns Hopkins scientists say, and pave the way for treatments that overcome the cells» drug resistance.
Following one of these associations, we validated a drug combination predicted to overcome resistance to MEK inhibitors by co-blockade of GSK3, which was not found based on associations with genomic data.
But it is also possible that the years of stress on her pancreas not to mention the drug you said caused some damage might have done sufficient damage that it can't produce enough insulin on its own to overcome even small amounts of insulin resistance caused by small amounts of meat, eggs or dairy and that for her only a 100 % WFPB diet will allow her to control her blood sugar without medication.
They can also overcome apoptosis resistance by BCL2, and overcome P - glycoprotein / MDR drug resistance, as well... Continue reading →
Potential new agents are also being investigated that it is hoped will overcome limitations of the current options, which include a narrow antiviral spectrum, ineffectiveness against latent virus infections, development of drug - resistance and toxic side effects.