Sentences with phrase «overexpression of»

A second mouse model, induced by overexpression of IL - 17 in skin, also shows bone loss, and suggests that the deregulation of the protein is sufficient to cause this effect.

Due to overexpression of genes in trisomic cells, abnormal neuronal development and functional changes occur in the central nervous system of DS patients.

Wild - type mouse microglia respond in a dose - dependent fashion to HS - oligosaccharides isolated from MPS IIIB patients with overexpression of macrophage inflammatory protein 1α (Mip1a or Ccl3) and interleukin 1β mRNAs.

In contrast, the relative uniform overexpression of MELK in basal - like breast cancer makes this gene a unique target if its functional importance can be established.

The team tested whether overexpression of PGC1 - alpha could protect cultures of rat brain cells from the pesticide rotenone, which inhibits complex I of the electron transport chain in neuronal mitochondria and produces many symptoms similar to those of Parkinson's.

Overexpression of HER2 is a marker for poor prognosis in breast cancer and is often correlated with increased metastasis, including to the CNS [18], [19].

Transgenic overexpression of APOC3 in mice also led to hypertriglyceridemia that was likely due to defective lipolysis (20), but it should be noted that an excess of any apolipoprotein has a similar effect (26 — 29), probably by shielding the core TG and preventing LPL access.

Overexpression of Bmal1 in the skeletal muscle has a significant effect on the architecture of the skeletal muscle in that it increases the size of each individual muscle fiber and presence of Type IIb fibers (fast - twitch, glycolytic).

The role of gene regulation in C. auris drug resistance mechanisms and host interactions — such as overexpression of ERG11 and other known fluconazole resistance genes — are currently unknown.

Nosrat, I.V.; Margolskee, R.F.; Nosrat, C.A. (2012) Targeted taste cell - specific overexpression of brain - derived neurotrophic factor in adult taste buds elevates phosphorylated trkb protein levels in taste cells, increases taste bud size, and promotes gustatory innervation.

The current studies were designed to determine whether chronic overexpression of low density lipoprotein (LDL) receptors in the liver would protect mice from the increase in plasma LDL - cholesterol that is induced by high - fat diets.

«In fact, we became interested in Rett due to others groups» observations of MeCP2 regulation of BDNF expression and genetic overexpression of BDNF improving behavioural deficits in Mecp2 mutant mice,» recalls Pozzo - Miller.

Genetic overexpression of BDNF has previously been reported to improve defective behaviours in Mecp2 mutant mice.

This matters when diagnosing leukaemia, where overexpression of genes makes the cell's genome change shape.

Third, ectopic overexpression of wt STAT1 in U3A cells was unable to induce the reporter gene expression without IFNα, whereas mutant STAT1 - Y701F remained responseless even under IFNα treatment (Fig. 1C), indicating that STAT1 activity depended on its phosphorylation.

On the other hand, overexpression of miR7 significantly decreased the mammosphere - forming ability of primary breast tumor cells (Fig. 5D).

Hepatic Overexpression of Hormone - sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis.

Tobacco leaves showing transient overexpression of genes involved in nonphotochemical quenching (NPQ), a system that protects plants from light damage.

Benedetta Artegiani (Calegari, TUD)-- «A Transitory Overexpression of Cdk4 / CyclinD1 Triggers a Greater Expansion of Neural Stem Cells and Neurons in the Adult Mouse Brain» (2012)

Duryagina R, Thieme S, Anastassiadis K, Werner C, Schneider S, Wobus M, Brenner S, Bornhäuser M Overexpression of Jagged - 1 and its intracellular domain in human mesenchymal stromal cells differentially affect the interaction with hematopoietic stem and progenitor cells.

Overexpression of CXCR4 along with SDF - 1 promotes the pathogenesis of systemic lupus erythematosus (SLE)[51 - 53].

Unphosphorylated STAT3 could drive overexpressions of certain oncogenes (such as M - RAS and MET), which contributed to cellular transformation (34).

Overexpression of ABL1 and ABL2 in both 1833 and parental MDA - MB - 231 breast cancer cells increased TAZ abundance (fig.

Overexpression of ZNF217 provides an advantage to tumor cells by allowing cells to infinitely proliferate and turning down pathways that typically tell cells to mature into functional cells (bone, blood, skin cells).

Overexpression of p11 increases 5 - HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice.

Additionally, the team found that induced lifelong overexpression of Nampt, an enzyme important in making NAD, prevented the natural decline in NAD and partially preserved exercise capacity in aged mice.

However, in the subjects with obesity or overweight, the researchers noted significant evidence of increased glucose (sugar) transport into cells and overexpression of known fat - producing genes, compared with fat biopsy samples from subjects who did not consume low - calorie sweeteners.

Downstream of the signaling system, Runx2 overexpression led to overexpression of bone - related genes, including genes expressed by osteoblasts, osteoclasts and osteocytes.

In contrast, overexpression of ctgfa resulted in increased bridging, axon regeneration and overall healing.

Overexpression of ZMYND11 in an osteosarcoma cell line and a triple - negative breast cancer cell line inhibited tumor growth.

They investigated whether overexpression of Isl1, an inner ear progenitor gene with roles in development and differentiation, could be effective in protecting the inner ear.

The current data indicate that unregulated overexpression of LDL receptors can protect against diet - induced hypercholesterolemia in mice.

The data from the Greenberg lab converge to suggest that Rett Syndrome may result from a relatively subtle yet widespread overexpression of long genes with functions important for the brain while the Duplication Syndrome could be due to under expression of these same genes.

Our results suggest that frequent overexpression of Aurora Kinase in cancer may reduce RUNX3 transcription activity, leading to cell division and formation of tumours.

Overexpression of GARP reduced the proliferation and activation of B cells.

Likewise, previously observed increases in fruit fly lifespan associated with overexpression of dSir2, the equivalent to sir - 2.1 in flies, disappeared when Gems and colleagues backcrossed the modified flies with ordinary ones.

Studying its effects in mice, the researchers found that overexpression of IGF2BP3 in the bone marrow leads to proliferation of hematopoietic stem cells and B cell progenitors, reproducing some features of MLL - rearranged B - ALL.

All of these could be potential treatment targets for cases of MDS triggered by overexpression of TRAF6, according to Starczynowski, who said future studies will test their therapeutic potential in mouse models of MDS.