Sentences with phrase «own calcium channel»

In many nerve cells, magnesium serves as Nature's own calcium channel blocker, preventing calcium from rushing into the nerve cell and activating the nerve.

Your physician may prescribe Nifedipine, a calcium channel blocker, which helps increase blood flow and is safe for breastfeeding moms.

Therefore, Lambert - Eaton syndrome IgG reacts with voltage - dependent calcium channels and blocks their function, a phenomenon that can account for the presynaptic impairment characteristic of this disorder.

The pathogenic IgG modified neither kinetics of calcium channel activation nor elementary channel activity, suggesting that a reduction in the number of functional calcium channels underlies the IgG - induced effect.

Immunoglobulin G (IgG) antibodies from patients with the syndrome, applied to bovine adrenal chromaffin cells, reduced the voltage - dependent calcium channel currents by about 40 percent.

If one component was missing in this triplet consisting of auxin transporter, receptor or calcium channel, there was no cellular response.

Since calcium channels are only found in heart and brain tissue, the researchers sought a drug approved to block these pathways.

In fact, the study of additional auxin mutants suggested that both a special receptor complex and a calcium channel were involved.

When the two proteins that form the calcium channels were mutated, the neuron was no longer activated.

The researchers also identified the specific neuron responsible for detecting high pH. They did this by showing that when a specific sensing neuron, called the ASH neuron, was destroyed by laser microsurgery, the worms no longer avoided high pH. Going another step further, the researchers also identified some of the proteins involved in the response to high alkalinity, which make up a calcium channel.

Toshihiro Sassa and Takashi Murayama, the first and second authors of the paper, respectively, say, «we would like to identify the other genes involved in downstream signaling from this calcium channel to understand how the signal leads to aversion to high pH.» Sensing alkaline environments is only the first step; the worm must then quickly react to the stimulus by moving away.

The pepper - derived compound creates a sensation of heat in patients who apply the cream by binding to TRPV1s, heat - activated calcium channels that are located on the surface of pain - and heat - sensing neurons.

Seven of 10 mice exposed to the virus and inoculated with Zoloft one hour later survived, as did all 10 given Vascor, a calcium channel blocker also called bepridil.

Most established medications on the market, such as ACE inhibitors, beta - blockers, or calcium channel blockers, on average reduce systolic blood pressure by 10 - 15 mm Hg.

The authors show that the voltage gated calcium channels are present on the lysosomes that dispose of proteins.

Voltage-gated calcium channels can not form properly when cacophony is mutated, preventing fusion of the synaptic vesicle with the plasma membrane and neurotransmitter release.

Several years ago, when Feske and his colleagues were at another institution, they were the first to identify ORAI1, a new calcium channel, which is essential for calcium influx and T - cell function.

A study co-led by Ryuichi Shigemoto, Professor at the Institute of Science and Technology Austria (IST Austria), with Alain Marty, Professor at Université Paris Descartes, uncovers that a single docking site may use a single cluster of calcium channels and that both the number of docking sites and the number of calcium clusters change in parallel with brain age.

This led the researchers to a major conclusion, as Shigemoto explains: «Based on our results, we suggest that for each docking site, there is a corresponding cluster of voltage-gated calcium channels.

«A docking site per calcium channel cluster: Researchers find link between morphology and function of synapses.»

Specifically, they determined that the immune systems in genetically altered mice lacking the critically important calcium channel component STIM1 failed to control TB, leading to severe lung inflammation and premature death.

The study is meaningful in respect to the fact that it calls into question the role of the T - type calcium channel in the reticular thalamus, and is expected to provide an important theoretical foundation for understanding its role in the mechanism of absence seizures, as well as developing effective treatment methods for absence epilepsy.

In the patients» spheroids, interneurons migrated inefficiently but, by adding drugs that blocked the dysfunctional calcium channel, the researchers could reverse the problem.

Absence seizures are believed to be elicited by T - type calcium channels in the thalamic reticular nucleus of the brain that regulate influxes of calcium.

This causes voltage-gated calcium channel to open.

«Our study highlights the important role of STIM1 and calcium channels in shutting down the immune response to chronic infection and in preventing injurious inflammation,» Feske says.

They found that the number of functional docking sites matches the number of clusters of voltage-gated calcium channels in the presynaptic terminal.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

«Like in all immune modulatory therapies,» Feske adds, «the benefits of incomplete calcium channel inhibition need to be balanced against the dysregulation of the immune response that results when these channels are blocked completely,»

The implications of a common control element in sodium and calcium channels are vast, Yue says, including unified understanding of conditions that spring from defects in the calcium control of these channels.

«When we exposed a near - infrared laser beam to these animal models injected with both the nanoparticle and the genetically engineered immune cells, this caused calcium channels on the dendritic cells to open and we saw a corresponding increase in the number of T - cells that were activated,» said Han.

«It looked like this «resemblance element» might be a molecular time capsule derived from a primeval ion channel thought to have birthed distinct sodium and calcium channels a billion years ago,» Yue says.

They found that, as with calcium channels, increasing calcium concentrations caused calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.

For calcium channels, Yue's and other research groups found that the resemblance element supports an important function, preventing the channel from opening when the cellular calcium level gets high.

Calcium channel blockers, which are used to lower blood pressure, block breast and pancreatic cancer invasion by inhibiting cellular structures.

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro.

The induction of synapses required signaling through GABAA receptors and voltage-gated calcium channels and the newly formed synaptic structures rapidly gain functions.

A cryo — electron microscopy structure provides a framework for understanding function and disease mechanisms in a family of calcium channels.

Take voltage-gated calcium channels.

Further research determined that certain components of the cone snail venom, called conotoxins, targeted voltage-gated calcium channels, which, like sodium channels, handle communication between pain - sensing neurons and the brain.

The colorful snails yielded the first hint that these calcium channels could make a potent target for pain relief.

Their venom peptides hit a wide variety of pain targets, including sodium channels, calcium channels and other receptors.

«Biochemists uncover structure of cellular memory mechanism: Calcium channel controls thought, movement and metabolism.»

The latest research implicates both glutamate transmission and calcium channels in schizophrenia development.

The mice also scratched if they lacked the calcium channel that transmits chloroquine - induced itch signals and were exposed to chloroquine.

«It appears there is cross-talk between pathways called calcium channels in sensory nerve cells that process the itch signal.»

The results should therefore be interpreted with caution, although the Nature paper findings do suggest that calcium channels are a viable drug target.

When the IP3R calcium channel receives signals, it creates a pathway for calcium ions to move across cell membranes.

The researchers studied calcium channels in neurons, which allow for the transport of calcium ions from one nerve cell to another, helping the cells transmit itch signals from the skin to other cells in the spinal cord.

The calcium channel blockers might improve memory by countering this effect.