Sentences with phrase «own cell fate»
A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha.
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Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.
The team lead by Prof. Verdon Taylor was able to demonstrate for the first time a cell - intrinsic mechanism regulating stem cell fate.
Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.
The study sought to test whether the surface alone, absent any added soluble factors to influence cell fate decisions, can have an effect on differentiation.
In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.
Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.
They discovered novel mechanisms in cells with the ability to activate pathways that crosstalk one to another and then assemble consolidated responses that decide cell fate.
What these cell fate determinants are and how they are distributed when a stem cell divides is another big question.
In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.
Interestingly, centrosomes have also been linked to the segregation of cell fate determinants.
«In addition to advancing our understanding of human embryonic development, the findings suggest we may be able to use metabolites, relatively simple compounds, to alter cell fate in the treatment of common disorders.»
Cas is required for polar and stalk cell fate specification, while Eya is a negative regulator of these cells» fate.
«It's a change in cell fate, back to neural crest status.»
«What changes a cell, or what regulates a cell to follow certain cell fate decisions?
Another view is that tumors can become resistant to therapy by a process called cell fate decision, by which some tumor cells are killed by therapy and others become cancer stem cells.
If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.
In that case, the genetic information within the chromosome copies remains the same, but the type of cell, or «cell fate,» is different.
Now known as a blastocyst, the embryo undergoes a dramatic division of cell fate, forming a distinct outer layer of cells and an equally distinct bulge of about 20 or 30 cells on the inside.
If mechanical stresses can influence cell fate — and Levenston's research is showing that it can — then one day it may be possible to use these biomechanical manipulations to engineer cartilage, ligament, or muscle.
Because of the consistency among many cells, they concluded that TCF - 1 control of T - cell fate is fundamentally important in determining what a cell will become.
«Sniffing out stem cell fates in the nose: Using single - cell RNA sequencing and clever statistical analysis to track stem cells as they mature.»
These experimental systems allow scientists to dissect key molecular pathways that specify cell fate decisions in embryonic development,» said team leader Lin He, a UC Berkeley associate professor of molecular and cell biology.
«This finding not only identifies a new mechanism that regulates totipotent stem cells, but also reveals the importance of non-coding RNAs in stem cell fate.»
«Scientists reprogram embryonic stem cells to expand their potential cell fates: Releasing molecular brake gives pluripotent stem cells potential akin to fertilized egg.»
The relative simplicity of the process means biologists have a much greater chance of reliably influencing stem cell fate.
Such modifications, including methylation, acetylation, ubiquitination, and phosphorylation, often result in the alteration of gene expression levels that determine cell fate.
The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.
Low levels of BMPs allow dorsal cell fate specification (e.g., neural tissue; formation of head structures), whereas higher levels of BMPs direct ventral cell fate specification (e.g., epidermis, blood, formation of tail structures).
«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
His work has focused on discovering and characterizing novel small molecules that can control various cell fates and functions, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.
Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types, including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.
The pathway that it takes decides in which valley it will finally settle, providing a metaphor for the acquisition of a specific cell fate.
«We see elements of this framework of primary and secondary cell - fate determinants throughout the hematopoietic system,» said study author Harinder Singh, the Louis Block Professor of Molecular Genetics & Cell Biology and a Howard Hughes Medical Institute Investigator at the University of Chicago, «and we suspect such networks also regulate cell fate in other systems.»
Dietmar J. Kappes discovers a mouse with a mutation in a master regulator gene controlling T cell fate.
Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).
A two - step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.
With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?
These results suggest EFTF - expressing pluripotent cells are directed to an embryonic eye field - like cell fate.
These observations suggest the EFTFs can direct pluripotent cells to an embryonic eye field - like cell fate.
Dozens of protocols already exist, to achieve cell fates very accurate.
HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.
We are interested in the molecular mechanisms that regulate cell fate.
He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.
Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.
Each cell fate is characterized by a regulatory network of factors, typically transcription factors that maintain a specific state through reciprocal feedback interactions.
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies
Her group is particularly interested in the cellular and molecular mechanisms which control lung epithelial stem cell fate decisions.
Discussion themes included: - stem cell heterogeneity - stem cell fate decisions - stem cells in regeneration & development - stem cells in disease & treatment - stem cell related bioengineering & biomaterial - theoretical stem cell biology - mathematical modelling with a focus (but no restriction) on neural stem cells, hematopoietic stem cells and diabetes.
Inhibiting EMT arrests cell fate decision in these experimental models, suggesting a mechanistic link between both processes that has never been understood.