This type of diabetes strikes in the early teenage years and begins with the immune system destroying
the cells in the pancreas that produce insulin, according to Patrick Holford, founder of the Institute for Optimum Nutrition in London.
Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin - producing (islet, or islets of Langerhans)
cells in the pancreas.
Suppose it kills
cells in the pancreas or in another organ?
If the tumor that Jobs had removed in 2004 had begun to break down prior to the surgery, White says, the tumor's dead cells could have released protease and lipase enzymes that may have damaged beta
cells in the pancreas, which produce insulin.
A FAULTY internal clock in
the cells in the pancreas that produce insulin could be behind type 2 diabetes — a condition in which the body is unable to produce or use insulin properly.
People with diabetes can no longer regulate their blood sugar levels effectively via the hormone insulin, which is produced by beta
cells in the pancreas.
«Our conclusion is that by pushing the mice into an extreme state and then bringing them back — by starving them and then feeding them again —
the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning,» says senior author Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute.
The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet
cells in the pancreas to survive.
Four years ago, the research team of Pedro Herrera (University of Geneva) first cast doubt on this assumption when they demonstrated that a few alpha
cells in the pancreas of genetically modified diabetic mice changed into beta cells.
This leads to high blood glucose values; the function of the insulin - producing
cells in the pancreas is also negatively influenced.
In this type of diabetes, the body destroys insulin - producing
cells in the pancreas, resulting in high blood glucose levels.
Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system's destruction of the beta
cells in the pancreas.
In those mice, but not in normal mice, they found that caerulein caused existing alpha
cells in the pancreas to differentiate into insulin - producing beta cells.
A new study by researchers at Sanford - Burnham Medical Research Institute (Sanford - Burnham) has found that a peptide called caerulein can convert existing
cells in the pancreas into those cells destroyed in type 1 diabetes insulin - producing beta cells.
The disease commonly starts in childhood and causes the body's own immune system to attack and destroy the insulin - producing
cells in the pancreas, leaving the patient dependent on life - long insulin injections.
Pancreatic neuroendocrine tumors, often referred to as «islet cell tumors» are a type of cancer that arises from hormone - releasing
cells in the pancreas.
Now, researchers have discovered that non-beta
cells in the pancreas can be transformed into insulin - producing cells, merely by exposing them to a growth factor called BMP - 7.
In «Diabetic rats cured with their own stem cells ``, we report how researchers cured diabetic rats by turning brain stem cells extracted through the nose into insulin - producing
cells in the pancreas.
In type 1 diabetes, beta
cells in the pancreas that make insulin — the hormone that keeps our blood glucose levels at a safe concentration — are destroyed by the immune system.
They also developed a unique cell - sorting technique to isolate islet cells from other
cells in the pancreas.
Islet autoimmunity, detected by antibodies that appear when the immune system attacks the islet
cells in the pancreas that produce insulin, is a precursor to type 1 diabetes.
Just as in pregnancy,
the cells in the pancreas that are responsible for the production of insulin change.
Since the late 1990s, researchers have been trying — and mostly failing — to accomplish this in type 1 diabetes, an immune disease that destroys
cells in the pancreas that make insulin and that mostly strikes children.
In the case of type 1 diabetes, it destroys the insulin - producing
cells in the pancreas, and in multiple sclerosis it strikes the central nervous system.
Type 1 diabetes hits when the body destroys insulin - producing
cells in the pancreas.
This is a faint echo of what happens inside the body of someone developing diabetes: Their T cells are activated against
cells in the pancreas much as they would be against a foreign invader, like a virus.
Insulin - producing cells (yellow) produce the hormone insulin (green spheres) and are surrounded by other
cells in the pancreas.
The most intriguing mutant type of mice were unusually thin; they generated more active osteocalcin, secreted more insulin, and produced many times more of the insulin - releasing
cells in the pancreas.
The disease begins when a person's own antibodies attack the insulin - producing
cells in the pancreas.
Furthermore, the normal ductal cells that are able to develop into pancreatic cancer represent about 10 percent of
the cells in the pancreas, complicating efforts to pinpoint the changes that occur as the tumor develops.
In an online issue of Cancer Discovery, the scientists described the molecular steps necessary for acinar
cells in the pancreas — the cells that release digestive enzymes — to become precancerous lesions.
As such, scientists hypothesise that cathelicidins may be involved in the control of type 1 diabetes, an autoimmune disease where certain cells in the immune system attack beta
cells in the pancreas which secrete insulin.
When the pancreatic islets, small masses of
cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.
Gobbling a slice of sweet pumpkin pie, for instance, causes beta
cells in the pancreas to secrete insulin, a hormone that allows the uptake of glucose and most amino acids into the tissues.
Beta
cells in the pancreas make the glucose - regulating hormone insulin.
The researchers, therefore, wanted to study whether the vaccine also increased the risk of developing autoantibodies against beta
cells in the pancreas and the occurrence of type 1 diabetes.
Newfound
cells in the pancreas give rise to neurons (red) and insulin - producing b cells (green).
Type 1 diabetes is an autoimmune disease in which the body destroys its own beta
cells in the pancreas.
That's because the insulin - making
cells in the pancreas, called b cells, are either missing or malfunctioning.
In type 1 diabetes, the immune system attacks
cells in the pancreas that make insulin.
Evidence isn't available showing whether the juice fasting Jobs reportedly tried accelerated the spread of cancer
cells in his pancreas, and possibly other organs, but Abrams notes that he rarely recommends juicing to the cancer patients he counsels.
Type 1 diabetes is a disease caused by the destruction of the insulin - producing
cells in the pancreas.
At the same time, 30 percent of those with type 2 diabetes had the same autoantibodies to their beta cells — the insulin - producing
cells in the pancreas — associated with type 1.
Stem cells can morph to take on any role in the body, making them theoretically useful to treat conditions ranging from type 1 diabetes (replacing insulin - producing
cells in the pancreas) to heart disease (taking over for damaged heart cells).
For them, the loss of insulin - producing beta
cells in their pancreas tends to be gradual, a result of overworking the cells.
Type 1 diabetes mellitus (T1D) begins with autoimmune destruction of insulin producing
cells in the pancreas, usually in children.
TYPE 1 DIABETES OCCURS when the immune system mistakenly attacks and destroys insulin - producing beta
cells in the pancreas.
In a study published in October 2008, Melton showed that it was possible to take an exocrine
cell in the pancreas of a live mouse and turn it into an insulin - producing beta cell without first going back to an undifferentiated iPS state.
The liposomes are made in the laboratory and designed to replicate the dying beta
cells in the pancreas, which characterize type 1 diabetes.
Islet transplants Insulin is normally produced by islet or beta
cells in the pancreas.