Sentences with phrase «own cells reprogrammed»
The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.
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In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adult).
He has more than fifteen years» experience in the life science industry, including the product development, market development and commercialization of cells, scaffolds, cell reprogramming tools and cell culture media for regenerative medicine and bioprocessing applications.
Scientists use cell reprogramming techniques to produce cells in the lab so that they can study diseases.
Nanog and Sox2 are among the enzymes used by researchers to generate iPSCs, therefore ZFP217 may represent another tool needed to achieve tight control over cell reprogramming.
«This research has broad impact, because by deepening our understanding of cell reprogramming we have the potential to improve disease modeling and the generation of better sources of patient - specific specialized cells suitable for replacement therapy,» said Plath.
There are currently several lines of research that explore the possibility of tissue regeneration through cell reprogramming.
iPSCs are adult cells reprogrammed to become every type of tissue.
Induced pluripotent stem cells (iPSCs)-- adult cells reprogrammed back to an embryonic stem cell - like state — may better model the genetic contributions to each patient's particular disease.
«Given everything we thought we knew about MYC and LIN41 at the time, we couldn't comprehend how these genes were so beneficial in somatic cell reprogramming, but absolutely useless in tumor reprogramming.
Work with skin cells reprogrammed to mimic embryos had suggested the mutation would be repaired in fewer than 30 percent of cells.
«Fat cells reprogrammed to increase fat burning.»
Like a Texan who keeps his drawl after moving to California, adult cells reprogrammed to resemble embryonic cells retain some signatures of the tissue from which they came.
In mice, when adult cells are forced to fuse with stem cells, occasionally one of the adult cells reprograms itself, regressing back to an undifferentiated state.
Patients could benefit from having their own cells reprogrammed into ones that could help treat disease, potentially eliminating the prospect of immune rejection.
The November 2003 application describes a possible approach to somatic cell reprogramming.
The U.S. patent office's database has more than 200 applications that mention somatic cell reprogramming.
Together with Kathrin Plath from UCLA, Vincent Pasque from KU Leuven led an international study into how adult cells reprogram to iPS cells.
«Cell reprogramming is revolutionising medicine, yet surprisingly little is known about how it actually works,» says stem cell expert Vincent Pasque, assistant professor at KU Leuven, Belgium.
Thanks to a promising technique known as cell reprogramming, this science fiction scenario may soon become reality.
iPS cells are mature cells reprogrammed to behave like those from an early embryo.
The stem cell transcription factor SOX2, which is critical for stem cells, cell reprogramming, and brain development, also is activated in astrocytes in the adult brain.
Earlier work has shown that grafted stem cells reprogrammed to become neurons can, in fact, form new, functional circuits across an injury site, with the treated animals experiencing some restored ability to move affected limbs.
«Big step for cell reprogramming.»
«Stem cell reprogramming factor controls change in cellular energy generation: Research reveals role for KLF4 protein in instructing cells to undergo metabolic changes while acquiring stem cell characteristics.»
The Lasker Foundation honored John Gurdon (top right) and Shinya Yamanaka (bottom right) for work on cell reprogramming and Brian Druker (top left), Nicholas Lydon (bottom left), and Charles
The group combines several cutting - edge single molecule imaging techniques to study how protein organization, dynamics and stoichiometry relate to protein function in several fundamental biological processes, such as intracellular transport, autoimmune neurological disorders or stem cell reprogramming.
Cell reprogramming involves making one cell type into another.
By matching normal and cancer cells from a patient, we can now study the differences — what molecules are key to tumor development and growth, and, ultimately, match treatments that might disable this cancer,» says the study's senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the Center for Cell Reprogramming (CCR) at Georgetown University Medical Center.
Cells reprogrammed in living mice (green) can contribute to both the placenta and body tissues of a developing mouse.
The 2012 platform also repeats previous calls for expanding federal funding «for the stem - cell research that now offers the greatest hope for many afflictions — with adult stem cells, umbilical cord blood, and cells reprogrammed into pluripotent stem cells — without the destruction of embryonic human life.»
They will also use it to study cell reprogramming, in which an adult cell is converted back into its pluripotent state.
In previous studies on liver - cell reprogramming, scientists had difficulty getting stem cell - derived liver cells to survive once being transplanted into existing liver tissue.
Skin cells reprogrammed to act like embryonic stem cells — a breakthrough first reported in human cells 2 weeks ago — are already showing promise as a therapeutic agent.
These findings will open up new ways to improve the efficiency of cell reprogramming and to drive stem cells to become different types of specialised cell.
The generation of iPSCs is relatively simple in concept: ectopically express a cocktail of stem cell reprogramming factors and wait for cells to de-differentiate.
The work recently received a $ 1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinson's - like symptoms in a mouse model of hypomyelinating disease.
In a study published in the journal Proceedings of the National Academy of Sciences, Shinya Yamanaka, MD, PhD, who first created induced pluripotent stem cells (iPSCs), and his colleagues at the Gladstone Institutes found a way to increase the efficiency of stem cell reprogramming through research on a rare genetic disease.
When researchers added a second step of T cell reprogramming for patients with residual disease, clinical benefit was seen in about 75 % of patients, said Dr. Kandalaft.
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming.
Efficient B cell reprogramming into iPS cells and transdifferentiation by C / EBPa (Graf's group in collaboration with Beato's, Nature, 2014; Mol Cell, 2012; Stem Cell Reports, 2015; Nature Cell Biol 2016; Cell Stem Cell, 2016).
Gladstone scientists discovered a way to enhance the efficiency of stem cell reprogramming with a gene mutation that causes «stone man syndrome.»
Chimeric mice generated from cells reprogrammed for pluripotency (induced pluripotent stem cells, or iPS cells) show significant health problems, pointing to further challenges that must be overcome before such cells can be used in the clinic, noted iPS researcher Shinya Yamanaka said on Saturday (June 14).
Adult stem cell research does take place at Georgetown, in the Department of Biochemistry and Molecular & Cellular Biology, in addition to groundbreaking stem - like cell research in the Center for Cell Reprogramming.
Topics: Chemistry and chemical engineering, Materials Science and Engineering, Koch Institute, Microfluidics, Stem cells, Cell reprogramming, Cells, Nanoparticles, Proteins, Faculty, Graduate, postdoctoral, Medicine, Research, Biology, DNA, Vaccines
The sequential processes of somatic cell reprogramming to create patient - specific hiPS cells, CRISPR / Cas9 gene editing, and single - cell cloning uniquely enable researchers to study how a specific genetic modification can influence function.
(2015) Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.
Shinya Yamanaka and Kazutoshi Takahashi (Gladstone Institutes) have discovered that MYC enables cells to be reprogrammed 10 % more efficiently by overcoming a block that stops cells reprogramming.
Announcement 2 All «cell reprogramming crowd» gathered for 3 days in Berkley, California for Cell Symposia «10 Years of iPS ``.
Somatic cell reprogramming takes differentiated cells and returns them to a pluripotent state.