Sentences with phrase «own cellular models»

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

«The previous cellular models were great,» says John Hogenesch, Professor of Pharmacology at the University of Pennsylvania Perelman School of Medicine, «but they needed high end imaging equipment that is out of reach for most labs and early stage startups.»

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

«Then we can do hypothesis - driven studies of this trait with animal or cellular models.»

For instance, CiRA's Kohei Yamamizu recently reported developing a cellular model of the blood — brain barrier made entirely from human iPS cells.

Interestingly, when compared to human cellular models, mouse models of PD did not demonstrate the same toxic cascade, according to the study.

In recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»

Drs. Scharf, Coppola, Mathews and Paschou are planning to take a closer look at the mutations using animal and cellular models.

While these studies were performed using a cellular model of hypertension, the implication of vitamin D3 on dysfunctional endothelium is much broader.

This new bone cancer model does a better job than previously used mouse or cellular models of «recapitulating» the features of bone cancer cells driven by key genetic changes.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Salk scientists create new molecular scissors to correct protein imbalance in cellular model of dementia

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

One challenge has been the lack of animal and cellular models that can precisely replicate the human disease for scientific investigation.

The Gene Editing Cellular Model Core Facility provides custom cellular model construction services using two technical platforms.

This flexibility gives us more versatility when creating cellular models of disease and development.»

Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

Molecular mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron - related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and cellular models and patients» biological samples.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

We have long - term interests and ample experience in generating somatic knockout cellular models for studying protein functions.

Here researchers were able to work with a human cellular model genetically identical to that of the patients.

Working at the University of California, Davis, the researchers created a new cellular model for studying Down syndrome by taking skin cells from patients with Down syndrome and inducing them into a pluripotent state.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

Other programs will use cellular models of heart disease created from stem cells to identify potential new drug targets.

The Cancer, Ageing and Somatic Mutation Programme seeks to provide leadership in data aggregation and informatics innovation, developing high - throughput cellular models of cancer for genome - wide functional screens and drug testing, and exploring basic scientific questions about the role somatic mutation plays in clonal evolution, ageing and development.

«I highly respect Novocell technologies and am pleased to collaborate with Novocell and explore the potential of their hES cell to islet cell advances in combination with our iPS cells as a potential new sources for the generation of cellular models and therapies for diabetes,» said Dr. Yamanaka, Director of Center for iPS Research and Application at Kyoto University.

My interest remains using the cellular models in the lab for new drug discovery.

Jingchun Chen (Nevada Institute of Personalized Medicine) received a UNLV IDeA Pilot Grant in the amount of $ 69,300 for her pilot study to develop a cellular model of microglia for schizophrenia research.

In the study, members of the Gottesfeld lab, led by first author Sherman Ku, a graduate student in the Scripps Research Kellogg School of Science and Technology, created a cellular model that did reproduce this feature.

The researchers hoped to create a cellular model to parse the effects of specific gene mutations, according to a press release, but in the process they discovered that skin cells from FOP patients were much more readily converted into iPSCs than cells from healthy individuals.

«We haven't had human cellular models that faithfully reproduce this feature of the disease,» said Gottesfeld.

This study is the first to investigate the phenotypic effects of the HAT activator CTPB, and to demonstrate that p300 / CBP HAT activation has neurotrophic effects in a cellular model of PD.

Using replicative senescence as a cellular model, we will dissect the functions of ATR and ATM in the process of aging and in premature aging diseases.

A small molecule activator of p300 / CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson's Disease

The advent of human - induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible.

These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients.

The project will analyse the chemical changes that occur in Unkempt in human cellular models of TSC.

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease.

Bottom line While research has shown some benefits with regards to ER + breast cancer cell death and prevention of metastases within mice and cellular models, it is recommended that human intake should be through diet only, not supplementation.

On an iPad (cellular model), you'll also find the IMEI.

If you're looking at the cellular model, there's only a 128 GB version and it costs a princely # 899.

While the Note 8.0 doesn't offer as much SKUs as apple's offerings, it does feature a cellular model and uses a mSD card slot to expand available memory.

The latest iPad has faster connectivity — if you opt for the wi - fi and cellular model.

The new iPad mini also now features multiple - input and multiple - output (MIMO) technology that offers up to 2x faster Wi - Fi, with both 802.11 a / b / g / n Wi - Fi and LTE cellular models that available with up to 10 hours of battery life.

It can buy ebooks and the cellular models can consume large chunks of cellular time.

But this time around, the cellular models include 4G / LTE wireless, along with additional 3G - network compatibility.

Then perhaps the cellular model would be the best purchase.

The Galaxy Tab A 10.1 is a mid-range tablet that's available in both Wi - Fi only and cellular models.

But there is a hardware difference between the Wi - Fi models and the 4G LTE cellular models, since the Wi - Fi models are powered by a Samsung octa - core processor, while the LTE models are powered by a quad - core Qualcomm Snapdragon 800 processor.