Sentences with phrase «own circulating tumor cells»

Chicago, GenomeWeb — A new study by researchers from Memorial Sloan Kettering Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cancer.

Currently marketed for research use by Biofluidica, the test's microfluidic channels use specific cancer antibodies to detect capture circulating tumor cells.

While many researchers are still developing affinity - based techniques for isolating circulating tumor cells, others are exploiting the physical differences between normal and tumor cells.

The other two major targets in the field, circulating tumor cells and exosomes, come with their own challenges.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

For investigators studying circulating tumor cells, the next step after sampling is to isolate the desired cells as quickly and gently as possible.

The field segregates into three major strategies: detecting free nucleic acids, isolating intact circulating tumor cells, and identifying extracellular vesicles from tumors.

«Circulating tumor cells have the advantage that they are... intact living cells,» says Michael Kazinski, senior director and head of global product management for sample technologies at Qiagen in Hilden, Germany.

«Circulating tumor cells have the advantage that they are... intact living cells.»

Shown here is a cluster of circulating tumor cells (red) from a patient with breast cancer.

Circulating tumor cell (CTC) clusters — clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.

«Circulating tumor cell clusters more likely to cause metastasis than single cells.»

Now a team of researchers in China has developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood, with potential applications for cancer screenings and treatment assessments.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.

In addition, while cfDNA correlated with tumor metabolism, no association was found with circulating tumor cells (CTCs).

The NanoFlare technology is the first genetic - based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood — no easy feat.

Further research could test these cancer stem cell gene expression at the RNA and protein level in circulating tumor cells and biopsies from patients on trial.

Currently, in another study, the researchers are focused on detecting circulating tumor cells in the blood of patients with a diagnosis of breast cancer.

«Our circulating tumor cell device can release a tumor cell captured from a blood sample, enabling single cell analysis,» says Liu.

The first stage of the trial, which involved an analysis of circulating tumor cells from a single blood draw of several dozen patients, has demonstrated strong potential.

The results were published in the journal Lab on a Chip (Lab on a Chip 17 (19), 3291 - 3299) in an article called: «Magnetic particles assisted capture and release of rare circulating tumor cells using wavy - herringbone structured microfluidic devices.»

Liu has been perfecting a microfluidic device the size of two quarters that has the ability to catch and release circulating tumor cells (CTCs)-- cancer cells that circulate in a cancer patient's blood.

Cancer cells that migrate into the bloodstream are called circulating tumor cells (CTCs).

For example, cancer cells floated above denser blood cells, which could allow clinicians to spot rare circulating tumor cells in a patient sample.

The role of rebiopsy and repeat analysis in the setting of post-treatment relapse, along with testing of blood samples for mutations in circulating tumor cells, cell free tumor DNA, or exosomes will be considered.

When the first laser of light hits the circulating tumor cells, they appear to be fluorescent green.

In a study using mice, the researchers found that using Dox and TRAIL in the pseudo-platelet drug delivery system was significantly more effective against large tumors and circulating tumor cells than using Dox and TRAIL in a nano - gel delivery system without the platelet membrane.

Researchers have for the first time developed a technique that coats anticancer drugs in membranes made from a patient's own platelets, allowing the drugs to last longer in the body and attack both primary cancer tumors and the circulating tumor cells that can cause a cancer to metastasize.

Researchers have found a group of circulating tumor cells in prostate cancer patient blood samples which are linked to the spread of the disease, according to new research presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool.

The scientists used a highly innovative cell separation technology Parsortix ™, developed by UK company ANGLE plc that is able to capture the circulating tumor cells.

«Our chip is currently the only device that can potentially capture circulating tumor cells and exosomes directly on the chip, which should increase its ability to detect metastasis.

The prognosis for metastatic cancer (also called stage IV cancer) is generally poor, so a technique that could detect these circulating tumor cells before they have a chance to form new colonies of tumors at distant sites could greatly increase a patient's survival odds.

A recent clinical study by Dr. Antonarakis and colleagues showed that mCRPC in men who had AR - V7 in circulating tumor cells was resistant to the hormone drugs enzalutamide and abiraterone.

AR - V7 status was assessed through an experimental blood test that measures AR - V7 mRNA in circulating tumor cells.

Berkeley researchers isolated circulating tumor cells from the blood of breast cancer patients, then used microscale physics to design a precision test for protein biomarkers, which are indicators of cancer.

So my field is science and technology, so my work is circulating tumor cells where I isolate cancer cells from blood of patients and isolate their DNA and RNA and try to sequence them and try to device treatments for cancer treatment and therapy.

To better study circulating tumor cells, the researchers collaborated with physician - scientists and industry engineers to develop a microfluidics system that separates these large cells into a concentrated sample.

Houston Methodist researchers led by Dario Marchetti, PhD, have developed a blood test that can identify circulating tumor cells to predict breast cancer patients at risk for developing brain metastasis.

Once settled in the microwell, the circulating tumor cells were burst open and the proteins released from inside each cell were separated according to differences in size or mass.

«Circulating tumor cells — cells from a tumor that have escaped into the bloodstream with the potential to spread into other tissues — are extremely useful for assessing a patient's disease in order to select the most appropriate treatment,» said UBC mechanical engineering professor Hongshen Ma, the lead researcher.

The study focuses on circulating tumor cells, a potentially rich source of information about a person's cancer.

The Berkeley researchers then analyzed each circulating tumor cell for the specific panel of cancer proteins.

The technique, described in Biomaterials, uses gold nanoparticles and Raman scattering, a technology previously developed by Qian and Nie for cancer cell detection (2007 Nature Biotech paper, 2011 Cancer Research paper on circulating tumor cells).

«Circulating tumor cells (CTCs) have been shed by the original tumor and entered the bloodstream — they can then form into new tumors if they lodge in distant tissue,» Wang says.

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell - induced coagulation.

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient.

UQ's Australian Institute for Bioengineering and Nanotechnology (AIBN) PhD student Jing Wang says the simple nanotechnology looked at changes in circulating tumor cells, which could indicate whether a cancer is attempting to spread and reveal its response to treatment.