Sentences with phrase «own hydrolases»

The researchers mixed RHP with a protein called organophosphorus hydrolase (OPH), which degrades the toxic organophosphates found in insecticides and chemical warfare agents.

The researchers used the random heteropolymers to stabilize organophosphorus hydrolase and then made fiber mats from the polymers.

Previous work had identified a number of enzymes (hydrolases) that are likely to have a role in parasite development.

Thus, the study concludes that the protective effect of the Mediterranean diet, combining unsaturated fats and vegetables abundant in nitrite and nitrate, comes at least in part from the nitro fatty acids generated which inhibit soluble Epoxide Hydrolase to lower blood pressure.

Hospitals already test babies for the enzyme phenylalanine hydrolase.

BIA 10 - 2474 inhibits an enzyme called fatty acid amide hydrolase (FAAH), which breaks down endocannabinoids in the brain.

This protein, bile salt hydrolase, is commonly made by gut bacteria and functions to change the chemical properties of bile acids in the gut.

Ag85 is a group of serine hydrolases that plays a critical role in the incorporation of mycolic acids into the mycomembrane.

One of the most potent compounds, WWL113, turned out to work principally by inhibiting Ces3, a serine hydrolase enzyme that scientists have not studied in the context of obesity or diabetes.

In this case, the researchers used a set of compounds, recently synthesized by Cravatt's laboratory, that tend to inhibit serine hydrolases — a vast enzyme family whose members participate in most biological processes in mammals.

It turns out SOBER1 can be classified as part of a vast protein superfamily known as alpha / beta hydrolases.

The problem was an enzyme called soluble epoxide hydrolase (sEH), which breaks down and inactivates EDP.

In noncarnivorous plants, jasmonic acid triggers the synthesis of self - defense toxins and molecules that inhibit hydrolases, enzymes that herbivores secrete to break down the plant's proteins.

As part of their counterattack, plants also produce their own hydrolases, which can destroy chitin and other components of insects or microbes.

In the flytrap, in contrast, jasmonic acid triggers a voracious response: Tens of thousands of tiny glands make and secrete hydrolases.

However, the lacY (F27S) mutant reached a higher density in M9 galactose compared to other Day 28 isolates, which also carried the same plasmid ‐ borne Bt glycoside hydrolase (Supplementary Fig S5A).

Population dynamics of library clones revealed Bt genes conferring significant fitness advantages in E. coli over time, including carbohydrate utilization genes, with a Bt galactokinase central to early colonization, and subsequent dominance by a Bt glycoside hydrolase enabling sucrose metabolism coupled with co ‐ evolution of the plasmid library and E. coli genome driving increased galactose utilization.

Protease and Hydrolase Subcommittee Drug Target and Chemistry Curation Subcommittee (Chair) Ex Officio (Senior Cheminformatician / Curator) Data Interoperability Subcommittee

Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer.

In this study, the authors reported having «functionalized» the silica pores by lining them with compounds that varied depending on the enzyme to be ensnared — amine and carboxyl groups carrying charges opposite that of three common, off - the - shelf biocatalysts: glucose oxidase (GOX), glucose isomerase (GI) and organophosphorus hydrolase (OPH).

Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation.

«Biosensing paraoxon in simulated environmental samples by immobilized organophosphorus hydrolase in functionalized mesoporous silica.»

Through collaborations with i.a. the SciLifeLab Biochemical and Cellular Screening facility, members of the Human Protein Atlas and teams supervised by Carolina Wählby (Uppsala University / SciLifeLab), Erik Sonnhammer (Stockholm University / SciLifeLab), and Pål Stenmark (Stockholm University), a comprehensive overview of the human NUDIX hydrolases has been produced.

Arand M, Cronin A, Adamska M, Oesch F. Epoxide hydrolases: structure, function, mechanism, and assay.

«One of the neat things this study shows,» said Cravatt, «is that even for enzyme classes as well studied as the hydrolases, there may still be hidden members that, presumably by convergent evolution, arrived at that basic enzyme mechanism despite sharing no sequence or structural homology.»

Some other frequent functions include proteases, hydrolases, secretion, activators, reductases and biosynthetic proteins.

The study, which appears as a Nature Chemical Biology Advance Online Publication on March 28, 2016, began as an effort in the Cravatt laboratory to discover and characterize new serine / threonine hydrolases using fluorophosphonate (FP) probes — molecules that selectively bind and, in effect, label the active sites of these enzymes.

We have identified a novel domain that we call the G5 domain (named after its conserved glycine residues), which is found in a variety of enzymes such as Streptococcal IgA peptidases and various glycosyl hydrolases in bacteria.

Pulling FP - binding proteins out of the entire proteome of test cells and identifying them using mass spectrometry techniques, the team matched nearly all to known hydrolases.

We show that oxidative modifications of ubiquitin carboxyl - terminal hydrolase L1 (UCH - L1), γ - enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH - 1) are present in the brain of familial AD... subjects.

A new study exploring the NUDIX hydrolases in human cells provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets.

Furthermore supraphysiological levels of many acidic hydrolases have no deleterious effect.

This work on glycoside hydrolases, completed in 2014, not only characterizes the functional diversity of these enzymes, it also identifies ways to combine them to optimize the processing of plants for energy.

The accumulation of lysosomes and their hydrolases within neurons is a well - established neuropathologic feature of Alzheimer disease (AD).

Monroe, J.D., A.R. Storm, E.M. Badley, M.D. Lehman, S.M. Platt, L.K. Saunders, J.M. Schmitz, and C.E. Torres (2014) β - amylase1 and β - amylase3 are plastidic starch hydrolases in Arabidopsis that appear to be adapted for different thermal, pH, and stress conditions.

In this assay SAHH (S - adenosylhomocysteine hydrolase) and adenosine deaminase convert the methyltransferase reaction product (S - adenosylhomocysteine) to homocysteine and inosine.

High - Throughput In Vitro Glycoside Hydrolase (HIGH) Screening for Enzyme Discovery, Dae - Wan Kim, Harshal Chokhawala, Matthias Hess, Craig Dana, Zachary Baer, Alexander Sczyrba, Edward Rubin, Harvey Blanch, Douglas Clark, Angewandte Chemie, doi: 10.1002 / anie.201104685, September 16, 2011.

In recent work, Brian Fox and colleagues at the Great Lakes Bioenergy Research Center at the University of Wisconsin - Madison characterized glycoside hydrolases, enzymes that digest cellulose and can be used to turn plants such as switch grass into biofuels.

Supplementing with Non-Glycoside Hydrolase Proteins Enhances Enzymatic Deconstruction of Plant Biomass, Xiaoyun Su, Jing Zhang, Roderick I. Mackie, and Isaac K. O. Cann, PLos One, http://dx.doi.org/10.1371/journal.pone.0043828, Sept. 7, 2012.

Functional Diversity of Four Glycoside Hydrolase Family 3 Enzymes from the Rumen Bacterium Prevotella bryantii B14, Dylan Dodd, Shinichi Kiyonari, Roderick I. Mackie, Isaac K. O. Cann, Journal of Bacteriology, 192 (9): pp. 2335 - 2345, May 2010.

Bile salt hydrolase - mediated inhibitory effect of Bacteroides ovatus on growth of Clostridium difficile — Soobin Yoon — Journal of Microbiology

A comparison of optimum temperature and activity in increasing concentrations of [C2C1Im][OAc] demonstrates that cellulases with higher optimum temperature are more likely to remain active in higher concentrations of [C2C1Im][OAc], further strengthening the link between thermotolerance and [C2C1Im][OAc]- tolerance for glycoside hydrolases.

Characterization of a tobacco epoxide hydrolase gene induced during the resistance response to TMV

deCODE genetics (Nasdaq: DCGN) today announced that it has begun enrolling patients for its Phase IIa clinical trial for DG051, the company's leukotriene A4 hydrolase inhibitor being developed for the prevention of heart attack.

In this paper, we describe an ancient lepidopteran LGT of a glycosyl hydrolase family 31 gene (GH31) from an Enterococcus bacteria.

The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria

Reykjavik, ICELAND, January 9, 2008 — deCODE genetics (Nasdaq: DCGN) today announced positive topline results from its Phase IIa clinical trial for DG051, the company's leukotriene A4 hydrolase inhibitor being developed for the prevention of heart attack.

In this study we make use of the recently completed Danaus plexippus genome to identify a bacterial LGT of a glycosyl hydrolase from Enterococcus, show that the LGT is ancient in Lepidoptera, and for one species provide molecular evidence for its insertion into the genome.

A combination of genomic (available here, here, here and here) and proteomic analyses indicated a glycoside hydrolase family 12 protein was critical in the high activity of one consortium.

Cravatt et al. «Supersensitivity to Anandamide and Enhanced Endogenous Cannabinoid Signaling in Mice Lacking Fatty Acid Amide Hydrolase», Proc.