Despite the lack of medical consensus, Viome isn't the only company looking to analyze
microbiome to improve health.
Using
microbiome analysis technology first developed in Los Alamos Lab to combat disease warfare, the company takes the samples and creates RNA and metabolic profiles for each customer.
When the research team took fecal samples from responding patients and transplanted them into germ - free mice — «essentially reconstituting the mice's gut
microbiomes with a responding patient's microbiome,» she says — they discovered that the mice had better immunity.
«Could it be that patients who have a fiber - rich diet with more whole grains — that is, with a more
microbiome - friendly diet — might do better on cancer treatment?»
Some small studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the gut
microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.
As I've said, there have been a number of research papers of late, led in large part by the work of French scientist Laurence Zitvogel, that are building a strong case for a central role for
the microbiome in cancer treatment response.
And what we found is that, in patients who responded to the treatment, they actually had a much higher diversity of bacteria in their gut
microbiomes compared to non-responders.»
«It also brings in the question of diet,» says Wargo, who is now working on new clinical studies on
the microbiome with the Parker Institute for Cancer Immunotherapy.
«The bottom line is that there are clear differences in how
the microbiome of somebody who is obese versus somebody who is lean responds to exercise,» Woods said.
Over the past few years, even since launching the company, a lot has been learned about the gut - brain axis and
the microbiome, the assortment of all the bugs that live in and on you that's an integral part of the gut, Kallyope CEO Nancy Thornberry told Business Insider.
The bigger risk is stymying our chances of ever discovering whether life existed on Mars before human beings and their grubby
microbiomes get there.
The «
microbiome,» or the collection of organisms that reside within the human body (especially the gut), has become a big new interest area for a number of major pharma companies like Merck and smaller biotechs alike.
«In our case we started off with consumers and citizen scientists, understanding
the microbiome, and we found something in our data set that was really stunning and valuable,» she says.
It was the largest scientific campaign ever at the time and responsible for collecting microbiotic samples from 2,500 people — the largest study that's ever been done on
the microbiome.
In a recent study, researchers in Sweden came up with a mathematical formula to help find the right eating plan for each person based on his or
her microbiome.
Want to diversify your gut
microbiome?
• A-Mansia, a Belgium - based
microbiome company, raised 13 million euros ($ 15.7 million) in funding.
«We wanted to do something that had never been done, which was to gather this huge
microbiome data set and generate value for suffering people,» she says.
«
The microbiome is a virtually unexplored frontier that holds the key to myriad opportunities for innovation,» said Will Rosenzweig, dean and executive director, The Food Business School.
Earlier this year, he told Motherboard he was working on technology that would allow a woman to «hack into
her microbiome and make her vagina smell like roses and taste like Diet Coke.»
After determining the makeup of
her microbiome — in effect, taking a census of the microorganisms that reside in her vagina — the company will supply a personalized regimen of probiotic supplements designed to promote optimal health.
For those with a less diverse
microbiome, the diet had a positive impact on their metabolic health — meaning a lowered their risk for type 2 diabetes and other diseases related to how the body processes food.
And now, researchers at the Chalmers University of Technology in Sweden have come up with a mathematical formula to find the right diet for each individual's
microbiome that will help them lose weight and prevent certain diseases.
The researcher's formula to determine the right diet based on an individual's
microbiome might be good news for people at risk for diseases associated with being overweight or obese.
A sample of your microbial makeup from fecal material, the mouth, or even your forehead can be genetically tested to figure out which bacteria are in your gut
microbiome, and whether it's diverse or not.
A lack of gut
microbiome diversity has been linked to type 2 diabetes, and increasing this diversity can help keep diseases like diabetes and heart disease away.
So if your body isn't full of diverse bacteria, the researchers suggest eating a diet full of dairy, vegetables, meat like chicken and fish, eggs, and oils, because it will diversify your gut
microbiome, which could improve your health.
Its effect on
your microbiome matters a lot as it has a profound effect on neuroinflammation.
To find out what was going on in
the microbiomes of four sets of differently shaped identical twins, researchers transferred some gut bacteria from a lean (human) twin to a sterile mouse: one with no foreign bacteria at all.
That's one reason researchers think
the microbiome might be a crucial part of not only obesity and diabetes, but also some of society's most pervasive mental health problems — the very illnesses that, too often, leave doctors stuck and patients frustrated.
While we can't use sterile mice to make any definitive conclusions about humans, the twins study, published in the journal Science last year, provided clear evidence that
the microbiome is involved in weight gain — something earlier research had only suggested.
«Organisms that detect changes in biochemistry (like those of
the microbiome) are able to tell when we are sick,» March explained.
Still, Tabor is hopeful that engineering
the microbiome will yield clinical applications soon.
Richman noted that research has started to show that
the microbiome is linked to mental health issues, such as depression and anxiety.
Richman's company sequences
the microbiome of customers who send in samples swabbed from their nose, mouth, skin, gut, and genitals.
There's still much more research we need to do to understand the intricacies of our own
microbiome.
Funding going toward companies related to
the microbiome — the trillions of bacteria that live primarily in our digestive system — increased more than 400 % between 2011 and 2015 and was up this year despite overall venture funding being down.
The microbiome consists of all the microbes that live in and on the human body that contribute to health and disease status of an individual.
Using advances in genomic sequencing, the human
microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.
By better understanding a person's
microbiome (gut, oral, skin, lung, and other body sites), the company anticipates developing improved probiotics and other advanced diagnostic and therapeutic approaches to improve health and wellness.
Seventure Partners, a subsidiary of France's Natixis, had already closed a $ 160m
microbiome - focused fund backed by corporate giants in 2015.
The study provides another example of the role of
the microbiome — the collection of microbes found in and on the body — in health and disease.
Although the FDA does not recognize it as a carcinogen, some experts disagree; the sweetener has been found to cause adverse effects in mice's gut
microbiome.
The company is a pioneer in the human
microbiome, which is essentially the bacteria that inhabits the gut and skin
Biotech's Encouraging Phase 2 Gut
Microbiome Data «Bodes Well» for Phase 3 Source: Streetwise Reports (3/14/18) H.C. Wainwright & Co. analyst Ram Selvaraju reported the latest study findings involving this biotherapeutic firm's lead asset.
• Azitra Inc, a Farmington, Conn. - based biotech company focused on harnessing
the microbiome to treat skin disease, raised $ 2.15 million in funding.
Other strategies for supporting
the microbiome include the intake of prebiotics, a form of dietary fiber that acts as fertilizer for good bacteria and probiotics, live active bacteria that can assist in restoring the balance of beneficial bacteria in the intestinal tract (particularly in fertile environments).
Check with
your microbiome on whether or not this is a super swell idea.
Research is showing that omega - 3 fatty acids, particularly EPA may help to support the tolerance of probiotic strains within your gut
microbiome; making sardines an excellent gut health superfood.
EverGoods Global Co (stand E4E) is presenting Naveen Scalp Energy Tonic, which utilises
the microbiome concept, combined with natural actives, to maximize the function of energising hair roots — toning and soothing the scalp and protecting against flaking (Soil Association Pavilion, Taiwan).