«We wanted to do something that had never been done, which was to gather this huge
microbiome data set and generate value for suffering people,» she says.
Biotech's Encouraging Phase 2 Gut
Microbiome Data «Bodes Well» for Phase 3 Source: Streetwise Reports (3/14/18) H.C. Wainwright & Co. analyst Ram Selvaraju reported the latest study findings involving this biotherapeutic firm's lead asset.
Franzosa and colleagues used publicly available
microbiome data produced through the Human Microbiome Project (HMP), which surveyed microbes in the stool, saliva, skin, and other body sites from up to 242 individuals over a months - long period.
Further comparisons with western
microbiome data showed that the Bantu microbiome composition falls on a spectrum between the BaAka and western populations.
Students who analyzed their own
microbiome data reported spending 31 percent more time researching the microbiome than students who used demo data.
Along with the genomic data gleaned from the sequencing of complete human genomes, HLI will also be generating
microbiome data for many of these individuals through its Biome Healthcare division, under the leadership of Karen Nelson, Ph.D..
«Other key public
microbiome data management systems such as MG - RAST, IMG and GOLD have also adapted the MIxS standards,» said Nikos Kyrpides, head of the DOE JGI Prokaryote Super Program and GSC Board member.
Along with
the microbiome data, HLI will capture and analyze each individual's metabolomic data.
Nephele: A cloud platform for simplified, standardized, and reproducible
microbiome data analysis — Nick Weber — Bioinformatics — October 2017
Bioconductor Workflow for
Microbiome Data Analysis: from raw reads to community analyses — Ben Callahan — F1000 Research — November 2016
Comparison of
microbiome data from the alcohol model, BDL, CCl4, and an obesity model noted that there was no common liver disease microbiome, suggesting that the intestinal microbiome differs by etiology of liver disease.
Like our lab run a ton of
microbiome data.
Not exact matches
«In our case we started off with consumers and citizen scientists, understanding the
microbiome, and we found something in our
data set that was really stunning and valuable,» she says.
Even in IBD patients, who have a very messed up
microbiome (a finding of the American Gut
data), the benefits of antioxidant therapy is well documented (see below studies).
«The newest
data we have is on the infant gut
microbiome: the «good» bacteria in our guts.
The contribution of the mode of delivery to the infant
microbiome has been evaluated.13, 15,24 However, no study has examined the effects of delivery mode and breastfeeding following adjustment for the other, and, to our knowledge, there are few
data on the effects of combination feeding (feeding breast milk and formula together).
If hormone surges are important for the
microbiome transmission during labor and in breast milk, as the unplanned Cesarean
data suggest, how could the natural hormone surges of labor be mimicked for planned Cesarean?
There are so many variables to the birth process that many of these questions could only be answered with extremely detailed
data of tens of thousands of mother - infant -
microbiome triads over time.
This is a highly limiting factor for research, because it complicates the annotation of
data obtained by molecular techniques, and because it has been shown that gut
microbiomes are to some extent specific to their host, and researchers have been using strains of other origin in mouse models.
When the team looked for it in
data from the Human
Microbiome Project, a large - scale project to sequence the DNA of all the microbes that live in and on our bodies, they found that it was present in 73 per cent of all 466 faecal samples.
Referring to these associations in bipolar subjects, Dr. Simon Evans concluded that, «The
data support the hypothesis that targeting the
microbiome may be an effective treatment paradigm for bipolar disorder.»
The researchers did a small study of existing genetic
data from the human skin
microbiome and estimate that 20 percent of the human population have S. epidermidis strains that make 6 - HAP on their skin, Gallo says.
But «one day,» Jackson says, «a genetic profile of our
microbiome will be taken by doctors, with treatments prescribed from instant molecular
data.»
France Córdova, director of the National Science Foundation, also addressed the forum, saying NSF's agenda over the next decade will come from «10 big ideas» including understanding the changing Artic, leveraging artificial intelligence, harnessing big
data, developing quantum enabled technology, studying the
microbiome and advancing research about gravitational waves.
«The
microbiome of a cadaver is an unknown
data set in biology,» she says.
To investigate, researchers from the Channing Division of Network Medicine at Brigham and Women's Hospital, led by Amir Bashan, PhD, and Yang - Yu Liu, PhD, analyzed
data from large metagenomic datasets (e.g. the Human
Microbiome Project and Student
Microbiome Project) to look at the dynamics of the gut, mouth and skin
microbiomes of healthy subjects.
When the researchers expanded their search to include all the
data from the Human
Microbiome Project, a large - scale project to sequence the DNA of all the microbes that live in and on our bodies, they found that the same virus was present in 73 per cent of all 466 human faecal samples.
«The
microbiome is incredibly complex and has been the subject of intense study in the last few years, due to the development of deep sequencing and most importantly, due to the ability to analyze this complex
data,» said Patterson.
ET: «What this
data analysis pipeline, moreover, creates is motivation to look for similar forms of gene loss in other types of symbioses, such as that between humans and their gut
microbiomes.
«We tend to think that the factors that determine where forests are on a landscape are largely driven by climate, but what these
data show is soils and the soil
microbiome community might be a lot more important than we have appreciated in the past,» she said.
Analyzing this wealth of
data required overcoming the formidable bioinformatics challenge of sorting and identifying millions of genetic sequences like puzzle pieces in order to reconstruct the complex biology of the ancient oral
microbiome.
«We are about six months away from having the
data to completely describe the bacterial
microbiome of grapevine tumors,» said Michael Savka, professor of biological sciences in the Thomas H. Gosnell School of Life Sciences at RIT, and organizer and contributor of the international study.
In addition, now that researchers have begun to understand how the
microbiome changes in the ICU, Wischmeyer says the next step is to use the
data to identify therapies — perhaps including probiotics — to restore a healthy bacterial balance to patients.
At the beginning of the semester, students were given the option to use their own personal information gained through a
microbiome kit, or they could use demo
data.
«Student class engagement soars when they use personal
data to learn: Study finds students who used
microbiome kits spent 31 percent more time engaged in course work.»
Michael Blaut, a microbiologist at the German Institute of Human Nutrition in Potsdam, Germany, says the mouse
data are «believable and remarkable,» but says he has a hard time imagining a mechanism that would account for three compounds as chemically different as aspartame, saccharin, and sucralose leading to the same changes in the gut
microbiome.
«Mining sequence
data in DOE JGI's Integrated Microbial Genomes &
Microbiomes system, which houses thousands of metagenomes, allowed us to find evolutionary relatives of our Klosneuvirus,» Schulz said.
The scientists analyzing this
data concluded that diet and lifestyle are by far the most dominant factors shaping our
microbiome composition.
Segal and Elinav believe that over time, with the further addition of
data to their study and those of others, these recent findings may be further validated, and the connection between our
microbiome, our genetics and our health will become clearer.
In addition to genetic
data and
microbiome composition, the information collected for each study participant included dietary habits, lifestyle, medications and additional measurements.
We also assess performance in real 16S
data, where we reanalyze previous genetic association
data to show that relative to other widely used quantification methods Karp reveals a larger number of
microbiome quantitative trait association signals.
Actinobacterial community structure in the Polar Frontal waters of the Southern Ocean of the Antarctica using Geographic Information System (GIS): A novel approach to study Ocean
Microbiome — P. Sivasankar —
Data in Brief
«The
data presented at AACR provide important new models and mechanistic insights that inform our planned development efforts to evaluate the ability of
microbiome therapy to augment immune checkpoint inhibitors,» said David Cook, Ph.D., Chief Scientific Officer and Executive Vice President of Research at Seres.
«It was the first analysis of the gut
microbiome among a foraging population, and the
data indicated that some of our old longstanding ideas about the differences between «good» and «bad» gut bacteria needed to be re-evaluated,» she said.
Seres Therapeutics (MCRB) Presents New Preclinical
Data Supporting the Development of
Microbiome Therapeutics for Immuno - Oncology at AACR
The complete genome sequence
data from the collected viruses will not only expand our knowledge of the virulence factors, but provide detailed information on evolution and transmission of RSV strains, host - pathogen interactions, and pathogen -
microbiome relationships that occur during viral infection.
The
data presented provide new insights on the potential mechanism by which Seres»
microbiome therapies could improve the outcomes of cancer patients treated with immune checkpoint inhibitors.
Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical
data supporting the development of
microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.
NIH recently awarded $ 8.2 million to four sequencing centers, to start building a framework and
data resources for the Human
Microbiome Project.
«By combining the crowd - funding model with the open - access
data analysis model that we pioneered with the Earth
Microbiome Project, we can finally give anyone with an interest in his or her microbiome an opportunity to participate,» said Knight, a Howard Hughes Medical Institute Early Career
Microbiome Project, we can finally give anyone with an interest in his or her
microbiome an opportunity to participate,» said Knight, a Howard Hughes Medical Institute Early Career
microbiome an opportunity to participate,» said Knight, a Howard Hughes Medical Institute Early Career Scientist.