Sentences with phrase «own pigmented cells»

These skin changes are due to hormonal influences on the skin pigment cells in these areas.»

They published their findings February 6, 2017, in Pigment Cell and Melanoma Research.

Orange Glow The inside of the eye derives its orange color from a layer of pigment cells inside the retina.

Uveal collectively refers to parts of the eye, notably the iris, that contain pigment cells.

Uveal melanoma (which is biologically distinct from skin melanoma) arises from the uvea's melanocytes, the pigment cells that give the eye its color.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

Vitiligo is characterised by the accumulation of a subgroup of T cells called CD49a +, which recognise and are ready to kill pigment cells.

New research links specific inherited genetic differences (alterations) to an increased risk for eye (uveal) melanoma, a rare form of melanoma that arises from pigment cells that determine eye color.

Scientists already knew that stem cells contained in a bulge area of hair follicles are involved in making hair and that SCF is important for pigmented cells, said Dr. Le, a member of the Hamon Center for Regenerative Science and Medicine.

The cells are harvested from a painless blister raised on the skin, then transferred to the area of involvement to replace the missing pigment cells and restore the individual's natural skin color.

Fossilized pigment cells suggest that the new species» plumage was glossy black, maybe even iridescent.

The authors say that pigment cells may be preserved in other samples of this phosphatized skin — people just haven't known to look for it.

They first pooled together information about colors in related modern snake species in the same family, Colubridae (which contains 70 % of all known snakes): specifically, which combinations of pigment cells produce which colors.

Taking samples from the back, belly, and side of the fossil skin, the team found different numbers of the three pigment cells at each location.

For example, she says that a chemical analysis — looking for actual pigment molecules — is necessary to show for sure that these are pigment cells.

«However, the initial mechanism by which the immune system identifies the monobenzone - exposed pigmented cells as dangerous, before attacking them, has been unclear so far,» reports Prof. Dr. Veit Hornung, who recently moved from the University of Bonn to the Ludwig - Maximilians - Universität in Munich.

«However, the multiple monobenzone exposures induced only natural killer cells to recognize and attack the pigmented cells.»

Nonetheless, white spots still developed in the animals» fur, and previously transferred malignant melanoma cells were destroyed, because the mice's natural killer cells remembered and attacked the pigmented cells.

«However, our results clearly show that natural killer cells can also carry out a long - lasting and effective immune reaction against the body's own pigmented cells, including malignant melanoma cells,» says Prof. Dr. Gunther Hartmann, Director of the Institute of Clinical Chemistry and Clinical Pharmacology of the University of Bonn.

However, the scientists have now been able to show that these special immune cells can indeed «remember» pigmented cells when they come into more frequent contact with a specific contact allergen.

An often - desired suntan can only form with the aid of the enzyme tyrosinase inside these pigmented cells.

Researchers at the University of Bonn and the Ludwig - Maximilians - Universität of Munich have decoded a new mechanism of how the immune system can specifically attack pigmented cells of the skin.

As a result, the immune system attacks the affected pigmented cells.

Pigmented cells of the skin are crucial as a protective shield against UV - radiation.

Only when monobenzone docks onto the tyrosinase enzyme, a so - called hapten is generated in the pigmented cell.

It lays the foundation for subsequent studies to investigate the biology of pigment cell differentiation and chemical identification of the pigments themselves (both of which I believe are beyond the scope of this study).

Here we report that in addition to producing an ommochrome body pigment, the planarian flatworm Schmidtea mediterranea generates porphyrins in its subepithelial pigment cells under physiological conditions, and that this leads to pigment cell loss when animals are exposed to intense visible light.

This has the potential to initiate a positive feedback loop in which ROS drive further uroporphyrinogen I oxidation, leading to oxidative stress and pigment cell death.

Neural crest cells are a type of stem cell; during vertebrate embryonic development, they eventually differentiate into specialized cells such as those that make facial skeleton cells or those that create pigment cells.

Aside from its opaque eyes and the polka dot - like chromatophores (pigmented cells that aid in camouflage) that cover its body, the glass squid is completely transparent.

The experiments also show that starvation increases the rate of pigment cell loss in light - exposed flatworms, which mirrors the worsening of disease symptoms some porphyria patients experience when they diet or fast.

These tumors occur primarily on the skin but may also arise in other tissues where pigment cells are found.

Following up on this observation, the authors show that this process is not simple photobleaching, but rather is caused by active elimination of pigment cells.

RNAi knockdown of KMO - 1, an enzyme involved in ommochrome synthesis that is expressed in pigment cells, leads to alterations in body color and increased porphyrin levels.

The authors report that genes encoding heme synthetic enzymes (that generate porphyrin intermediates) are expressed in pigment cells, and the first three enzymes in the heme synthetic pathway are also required for proper pigmentation.

Equally impressive is the ability of a caudal fin to regenerate bone, nerves, blood vessels, epidermal, and pigment cells in about 7 - 10 days following complete amputation.

«These white markings occur not because the dogs can not produce pigment but because they completely lack pigment cells in the skin in the areas that have white markings», says Izabella Baranowska Körberg who obtained her PhD degree at SLU on a thesis in which this study was included.

Organized by The PanAmerican Society for Pigment Cell Research Click here for meeting flyer.

In the article, the researchers show that the white coat color in dogs is caused by mutations in the MITF gene that is crucial for normal development of pigment cells.

A. Melanoma is a cancer of pigment cells and all melanomas share some characteristics but they also differ: the genetic changes which define cancers occur in the cancer cells at random and cancers are all therefore a little different.

Pigment cell & melanoma research.

Dr. Theos» research results were published in an article titled «PKD Domains Distinguish PMEL and GPNMB Localization» in a 2013 edition of the peer - reviewed journal Pigment Cell & Melanoma Research.

-- We have shown that the genetic change causing fibromelanosis is a complex rearrangement that leads to increased expression of Endothelin 3, a gene which is known for promoting the growth of pigment cells, explains Ben Dorshorst the post-doctoral researcher responsible for the work.

This trait involves a massive expansion of pigment cells that not only makes the skin and comb black but also causes black internal organs.

They went on to show that Sox10, a factor needed for the formation of skin pigment cells from neural crest stem cells during development, was present at high levels in naevi and melanoma samples obtained from both the mouse model and human patients.

Pigmented cells were enriched by manual dissection of expanded colonies followed by dissociation in 0.05 % Trypsin - EDTA.

(D) Large pigmented cells are observed in the subretinal space at 13 week post-graft.

iPS (IMR90)-3 cells readily differentiate into RPE cells and the differentiation protocol used in this paper is a highly efficient method of producing multiple confluent flasks of highly enriched pigmented cells.

In vitiligo, something is killing skin pigment cells (melanocytes), but the cause has remained obscure.

Pigmentation and the pigment cell form an ideal system for genetic analysis of a developmental system, since pigmentary mutations are readily detected and most often are not lethal.