It's the absence
of oxaloacetate that inhibits ATP generation via Krebs» cycle and necessitates ketone production.
Just recently I read an article Dr mercola wrote about ketosis but he advised against doing this diet while breastfeeding saying women
need oxaloacetate, a compound essential for creating lactose in breastmilk, which is essential for baby's growth.
So I did some more research and came across an article that states your body can
make oxaloacetate from protein too..?
Within the cells» mitochondria — the powerhouses of the cells — the acetyl - CoA combines with the
compound oxaloacetate to form citric acid.
Upstream ORFs and ATF4 - binding sites are found in many genes, but for the purposes of this review genes that carry out biosynthesis of non-essential amino acids (ASNS, alanine aminotransferase 2, PSAT, serine hydroxymethyltransferase 2, pyrroline -5-carboxylate reductase and glutamate -
oxaloacetate transaminase) and genes encoding amino acid transporters (cat1, ASCT1, ASCT2, SNAT2, SNAT7, LAT1, EAAT5 and xCT) are notably abundant [83,120].
Since oxaloacetate is formed from pyruvate (a metabolite of glucose), a certain level of carbohydrate is required in order to burn fats.
Ketones are produced when there is no longer
enough oxaloacetate in the mitochondria of cells to condense with acetyl CoA formed from fatty acids.
The cell's powerhouses, the mitochondria, will combine these acetyl - CoA stores
with oxaloacetate, creating citric acid.
But if you look at the recent data on utilising ketones during exercise, giving a small supply of glucose provides some substrate for anapleurosis (i.e.
regenerating oxaloacetate) to allow you to use the Acetyl - CoA coming from ketones or beta - oxidation of fats.
That's because women
need oxaloacetate, a compound essential for creating lactose for breastmilk, which is essential for their baby's growth.
As I mentioned in the Definitive Guide, dietary protein, along with glucose, is a source
of oxaloacetate.
This pathway allows glutamine to be converted into a variety of metabolic intermediates such as aspartate, asparagine, citrate and
oxaloacetate and pyruvate [103].
That's
oxaloacetate (from the Kreb cycle) and neuropeptide Y (a brain chemical) working with your hyperinsulinemia (feel like rocket science yet?).