Sentences with phrase «oxidative dna»

Several candidate mechanisms of CRCI have been proposed, including inflammation and cytokine dysregulation, chemotherapy - induced epigenetic changes, blood — brain barrier disruption, hormone deficiencies, oxidative DNA damage and shortened telomere length, and genetic susceptibility.21 — 26 However, the heterogeneity and design limitations within the emerging body of evidence have led to recommendations for harmonising study methodologies and moving towards multisite, longitudinal research.3 27 Such approaches would support the demonstration of robust relationships between measurable biological processes and cognitive outcomes.

There is some evidence that orally administered curcumin may even help protect intestinal mucosa in the gastrointestinal tract against oxidative DNA damage.

Researchers concluded that, «Overall, these results suggest that [phenolic compounds] may efficiently prevent the initiation step of carcinogenesis in vivo, because the concentrations effective against the oxidative DNA damage could be easily reached with normal intake of olive oil.»

A recently published paper entitled «Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain» by Abolhassani et al (1) suggests no.

There are other ones where it causes oxidative DNA damage.

Fortunately, the answer to this question was answered in the paper «Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease / vascular dementia» by Gackowski et al (2).

The study authors concluded that the Mediterranean diet plus CoQ10 «improves oxidative DNA damage in elderly subjects and reduces processes of cellular oxidation.

«One known type of damage is oxidative DNA damage.

Recently, researchers from the Faculty of Science, School of Community Health, Charles Sturt University (New South Wales) have found that obesity, which increases blood glucose levels, contributes to oxidative DNA damage.

Regnell CE, Hildrestrand GA, Sejersted Y, Medin T, Moldestad O, Rolseth V, Krokeide SZ, Suganthan R, Luna L, Bjørås M, Bergersen LH (2012) Hippocampal adult neurogenesis is maintained by Neil3 - dependent repair of oxidative DNA lesions in neural progenitor cells Cell Rep, 2 (3), 503 - 10 PubMed 22959434

Transcription coupled repair of oxidative DNA damage (PNAS 2000, 97, 8397 - 8402; Mol Cell, 2003, 12, 799 - 800).

The researchers used two common in vitro assays, the Comet assay and the long amplicon - qPCR assay, to test for genotoxicity and found that thirdhand smoke can cause both DNA strand breaks and oxidative DNA damage, which can lead to gene mutation.

Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.

Not exact matches

By controlling inflammation and upregulating antioxidant systems in the body, we can help keep our mitochondria healthy by protecting their DNA from oxidative stress (6).

This exceptional food offers antioxidant and anti-inflammatory protection to your cells, preventing DNA damage caused by free radicals and reduces oxidative stress which leads to premature aging.

The latter ties overproduction of free radicals to oxidative damage to lipids, proteins, and DNA, leading to chronic diseases such as atherosclerosis, cancer, diabetes, and rheumatoid arthritis.

Genes encoding ribosomal proteins, DNA replication and repair machinery, oxidative stress, and purine biosynthesis were differentially expressed in Wolbachia during the development of B. malayi female worms, suggesting a role of the bacteria in worm reproduction.

This results in cells having less mitochondrial DNA, decreased mitochondrial membrane potential and a faulty process in cell metabolism called oxidative phosphorylation.

The second method, called oxidative phosphorylation, produces free radicals, reactive forms of oxygen that can be particularly harmful to a cell's DNA.

They then measured levels of glutathione (a key antioxidant), oxidative stress and DNA damage in the blood samples, and levels of melanin pigments in the feathers.

«Oxygen by - products produced during normal metabolism can cause oxidative damage to biomolecules in cells, such as DNA and RNA,» explains Jian - Ping Cai, a researcher involved in the study.

These studies show that the DNA found inside mitochondria, the cellular structures whose job is to provide cells with energy, is particularly vulnerable, most probably because they handle oxidative chemical reactions.

Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified.Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.

The TMWG kit incorporates Cambridge Epigenetix's TrueMethyl oxidative bisulfite (oxBS) technology, which allows researchers to accurately quantify different DNA modifications at single - base resolution, as well as proprietary library preparation methods designed to overcome the limitations of traditional bisulfite library construction, and to improve the yield and quality of epigenetic data.

Her research team found that cellular oxidative stress (arising because of reactive oxygen species) increases in mice exposed to THS, damaging proteins, fats and DNA, and leading to hyperglycemia (excess glucose in the blood stream) and insulinemia (excess insulin in the blood)-- a condition also called insulin resistance.

MBD4 cooperates with DNMT1 to mediate methyl - DNA repression and protects mammalian cells from oxidative stress.

Among the most interesting ones identified were those associated with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding, calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.

Similar results were obtained by electrochemical voltammetric in situ detection of DNA oxidative damage caused by the reduced anthracycline doxorubicin, a classical chemotherapeutic which intercalates into DNA [81].

Topics presented will cover mitochondrial homeostasis, including mitochondrial DNA replication and repair, oxidative stress, calcium signaling and energy metabolism.

They can not replace damaged mitochoondrial proteins, but for the most part, they are pretty resistant to oxidative damage (particularly cytochrome c oxidase which is very oxidative damage resistant, much more so than is DNA).

Increased free radical induced oxidative stress plays a pivotal role in pathogenesis of many diseases including obesity, T2D and AP [7, 39 - 43] leading to macromolecular damage (DNA, protein and lipids), inflammation, ER stress and necrosis of acinar cells [44].

In the summer of 2010, we posted an entry about a significant advance in basic mitochondrial biology that held within it a tantalizing promise: a potentially new approach to obviating the problem of age - related accumulation of mutations in mitochondrial DNA (mtDNA), which are widely suspected to play an important role in the age - related rise in oxidative stress, Parkinson's disease, and age - related muscle degeneration.

Despite the protection offered by the cellular environment, the integrity of DNA is continuously challenged by a variety of endogenous and exogenous agents (e.g. ultraviolet light, cigarette smoke, environmental pollution, oxidative damage, etc...) that cause DNA lesions, interfering with proper cellular functions, such as transcription, inducing premature cellular death and finally premature ageing and organs dysfunctions.

Furthermore, its preventive effects against oxidative stress and DNA damage are well described [6].

A series of new mouse models have recently been developed in the laboratory that will allow us to dissect how DNA damage, oxidative stress and chromatin remodeling impact on mitochondrial integrity and stem cell decline during aging.

These off - target effects may actually be beneficial in treating IBD, primary sclerosing cholangitis, primary sclerosing cholangitis / IBD - related CRC, and asthma, whereby a multitude of abnormal signaling involving inflammation, oxidative damage, DNA damage, and apoptotic abnormalities exists to manifest itself into a diseased state.

This DNA becomes damaged in the course of normal cellular processes, and certain forms of mitochondrial DNA damage - to the thirteen genes needed for oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating more readily or being more resistant to quality control mechanisms.

Feb. 22, 2018 — New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.

Such diseases are believed to be initiated by mutations and rearrangements of the DNA sequence.DNA damage generated by ionising radiation, simple alkylating agents or endogenously hydrolytic and oxidative processes is corrected by the base excision repair (BER) pathway.

In response to a variety of stress signals, including nutrient deprivation, oxidative stress, dysfunctional telomeres, DNA damage and oncogene overexpression, normally dividing cells can permanently withdraw from the typical cell cycle.

Antioxidant consumption is especially important during pregnancy, helping protect fetal DNA from damage and also reduce maternal tissue damage associated with inflammation and oxidative stress.

Over time the amount of DNA / RNA diminish and become damaged due to increased oxidative stress and will consequently produce flawed copies of our own genetic blueprint.

This marker, which indicates oxidative damage to DNA, is also linked to aging and cancer (10, 11).

Not only is glyphosate toxic in and of itself, causing the inflammation, oxidative stress and DNA mutations that can trigger cancer, but — in a sort of biological «Catch - 22» — the chemical cripples the body's natural defense mechanisms that could otherwise help to detoxify and neutralize it.

«Energy deficits created through both CR and EX reduce DNA and RNA damage to WBC, potentially by reducing systemic oxidative stress», the researchers conclude.

DNA damage accumulates with age in the brain.55 - 56 Saturated fats and fats from cod liver oil are extremely helpful in regulating the oxidative stress in the brain as we age.

Both UVA and UVB promote premature skin aging (photo - aging), although UVA is the one that penetrates skin causing oxidative stress and damage of DNA, collagen and elastin, resulting in skin damage and ageing.

Cancer causing mutations may be due to impaired mitochondrial metabolism by the production of reactive oxidative species that cause DNA damage.

He Shou Wu stimulates the production of Superoxide Dismutase (SOD), the most powerful antioxidant in the human body, which works to protect to cellular DNA from oxidative damage, which is widely believed to be one of the primary causes of aging.

One reason might be the role of fat in inducing oxidative stress and creating free radicals, which are highly reactive atoms and molecules that damage DNA and cellular walls, ultimately killing heart muscle cells.