Not exact matches
«We also showed that TCL1 inhibits a mitochondrial enzyme required
for in
oxidative phosphorylation, leading to a reduction in oxygen consumption of the cells,» co-first author Shiho Aizawa explains.
This discovery provided the physiological basis
for subsequent development of fMRI and caused researchers to reconsider the dogma that brain uses
oxidative phosphorylation exclusively to fuel its functional activities.
van der Lee R, Szklarczyk R, Smeitink J, Smeets HJ, Huynen MA, Vogel R. Transcriptome analysis of complex I - deficient patients reveals distinct expression programs
for subunits and assembly factors of the
oxidative phosphorylation system.
Thirteen of these genes provide instructions
for making enzymes involved in
oxidative phosphorylation.
Modifications
for Mitochondrial MEDEVAC However, when they then went on to attempt to use their system to introduce WT mitochondrial tRNAs into MELAS and MERRF cybrids — and thus rescue
oxidative phosphorylation (OXPHOS)-- Teitell's group encountered a series of hurdles requiring additional modification of their constructs.
For this, the cells use the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle and as
oxidative phosphorylation.
Lin28a bound to and enhanced the translation of mRNAs
for several metabolic enzymes, thereby increasing glycolysis and
oxidative phosphorylation (OxPhos).
This DNA becomes damaged in the course of normal cellular processes, and certain forms of mitochondrial DNA damage - to the thirteen genes needed
for oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating more readily or being more resistant to quality control mechanisms.
Iron is useful
for participating in lots of different chemical reactions in the body, as part of normal metabolism, but it's also important
for caring oxygen to our tissues and oxygen is what we need in a process called
oxidative phosphorylation, which gives us energy.
This high demand
for energy in the brain is mainly achieved by ATP production during oxidation of glucose or
oxidative phosphorylation in the mitochondria.
Magnesium is required
for energy production,
oxidative phosphorylation, and glycolysis.