Sentences with phrase «oxidative signaling»

A fashionable contrary view has arisen: antioxidants not only don't help, they can do harm by interfering with oxidative signaling pathways.

But lack of antioxidants can make normal oxidative signaling tissue - damaging.

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

The oxidative signals produced by mitochondria are delicately balanced by the antioxidant defenses in healthy cells.

«What we've done is figure out that mitochondria need to produce a very specific oxidative signal in response to muscle damage in order to help injured muscles repair.»

The oxidative signals are also involved in growing the new blood vessels needed by the cancer tissues.

Not exact matches

Although much less research exists on monk fruit and its components, preliminary studies show promise for improving insulin signaling by protecting the pancreatic insulin - releasing cells from oxidative stress (3, 4).

Analysis of signaling pathways that were affected pointed to changes in mitochondrial function and oxidative phosphorylation, consistent with a number of studies showing perturbations of these pathways in neurodegenerative disorders.

«The animal and cell work suggest a number of possibilities, including disruption of sex hormone signaling, changes in adiponectin release, oxidative damage, and direct effects on muscle cells,» Melzer says.

Mice deficient in critical innate immune functions such as Toll - like receptor signaling or oxidative burst production spontaneously produce high - titer serum antibodies against their commensal microbiota.

«Our previous work has shown that obesity is associated with oxidative stress and inflammation, and inflammatory mediators are known to interfere with insulin signaling.»

The removal of BRCA1 from the cells, which simulated what could happen in the cells of a person with a BRCA1 mutation, resulted in increased lipid storage, decreased insulin signaling, reduced mitochondrial function and increased oxidative stress.

Although reactive oxygen species can damage cells when produced in high amounts, according to a study published online Sept. 5, 2017 by Science Signaling and featured on the journal's cover, these oxidative species are crucial signals that start the process of repairing myofiber.

Rats born of hypoxic pregnancy with no vitamin C treatment showed increased thickening of the walls of the aorta — up to 170 % above normal — and molecular markers of disease, such as an increase in the heart's heat shock proteins, a signal of cardiac oxidative stress.

Among the most interesting ones identified were those associated with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding, calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.

Topics presented will cover mitochondrial homeostasis, including mitochondrial DNA replication and repair, oxidative stress, calcium signaling and energy metabolism.

In Ames dwarrf, Snell Dwarf mice, Klotho mice, GHKO mice who have little IGF and GH; and live longer than wild - type; we see that indeed insulin and glucose / nutrient / energy pathways (which create oxidative stress through excessive nutrient via elevated glycation blood glucose creating high glycated albumin and hemoglobin), that aging is acted on by IGF through hormones, GFs, GHs, acting on insulin signals, which act on survival genes (DAF / SIRT / FOXO).

Each volunteer's blood was tested for the presence of molecules that signal oxidative stress, others that act as antioxidants, and nitric oxide metabolites.

Besides lipotoxicity (see section V.N) many other molecular mechanisms are involved, including mitochondrial dysfunction, oxidative stress, intramyocardial inflammation, involvement of the reninangiotensin system, altered insulin signaling or female - specific cardiac glycogen handling as a response to metabolic stress (308), and sex - hormone related myocardial calcium handling (309).

We showed that a chronic oxidative stress accelerates aging through accumulation of HIF (Hypoxia - Inducible Factor) and modulation of insulin signaling (Gerald, Cell, 2004; Laurent, Cell Metabolism, 2008).

Symposia II: Oxidative Stress and Sympathetic Regulation Experts will discuss how oxidative stress - associated signals regulate sympathetic activity and blood pressure, as well as nanoforumulated antiOxidative Stress and Sympathetic Regulation Experts will discuss how oxidative stress - associated signals regulate sympathetic activity and blood pressure, as well as nanoforumulated antioxidative stress - associated signals regulate sympathetic activity and blood pressure, as well as nanoforumulated antioxidants.

These off - target effects may actually be beneficial in treating IBD, primary sclerosing cholangitis, primary sclerosing cholangitis / IBD - related CRC, and asthma, whereby a multitude of abnormal signaling involving inflammation, oxidative damage, DNA damage, and apoptotic abnormalities exists to manifest itself into a diseased state.

The expression of micro-RNA miR - 663 was induced by mitochondrial reactive oxygen species production, an apoptotic signal and oxidative stress response, and miR - 663 induced the expression of nuclear - encoded mitochondrial respiratory chain subunits.

«They concluded that genetic differences and type of fat in the roundworm diet appears to be associated with longevity, and that the reason roundworms lived longer with MUFA might relate to less oxidative stress, or alteration in signalling pathways at cell level that improved their longevity.

In response to a variety of stress signals, including nutrient deprivation, oxidative stress, dysfunctional telomeres, DNA damage and oncogene overexpression, normally dividing cells can permanently withdraw from the typical cell cycle.

A number of studies have implicated the immune system (responsive to oxidative stress signals) in postpartum depression.

Nutraceutical modulation of GSH with a humanized native milk serum protein isolate, Immunocal: Application AIDS and cancer is oxidative stress and redox regulation: Cellular signaling, AIDS, cancer and other diseases.

Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation, establishing a vicious cycle of events in which saturated fat - induced free radicals cause dysfunction in the little power plants within our muscle cells, which causes an increase in free radical production and the impairment of insulin signaling.

Involvement of PI3K / PKG / ERK1 / 2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl - L - carnitine and alpha - lipoic acid against HNE - mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.

The insulin - independent oxidative upregulation of insulin receptor signaling activity (basic IRS) results in inhibition of autophagic removal of damaged cell structures (Autophagy) and ability to maintain post-absorptive plasma cysteine concentrations.

With age, ROS - induced aberrant triggering of the insulin signaling mechanism in the postabsorptive state inhibits autophagy, preventing maintenance of plasma cysteine and intracellular glutathione levels throughout the night and early morning hours, and initiating a vicious cycle of progressively increasing oxidative stress and mitochondrial dysfunction.

But in older individuals in whom basal levels of oxidative stress are already increased, aberrant insulin signaling during the fasting state that militates against mitophagy and further decreases glutathione stores, becomes the final straw.

Ketogenic diets have a long history of efficacy for disorders of the CNS, most notably epilepsy.46, 47 KBs are more efficient than glucose and induce less oxidative damage.47 Additionally, KBs are brought into the brain by monocarboxylate transporters — independently of glucose and insulin — so their uptake is not hindered when insulin signaling fails.51

«In addition, the role of mitochondrial dysfunctions, defects of the endolysosomal and autophagic systems, neuroinflammation, oxidative stress, altered insulin signaling in the brain, and increased permeability of the blood - brain barrier in AD - related neuropathology has been investigated as well.»

Nrf2 / ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS.

Take - home: Oxidative stress during exercise sends signals that increase mitochondrial number and efficiency to support the energy demands of exercise.

The Nrf2 - ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders.

Oxidative stress in tissue cells may trigger an inflammatory response by the NF - kappa B nuclear signaling pathway.

It also reduces oxidative stress and damage, lowers cholesterol, reduces inflammatory signaling molecules, promotes cleanup and induces protective mechanisms within the brain.

A number of studies have implicated the immune system (responsive to oxidative stress signals) in postpartum depression, as well as associated inflammatory markers like CRP and IL6.

An Overview of the Primary Signaling Pathways Related to Exercise, Oxidative Stress and Antioxidant Intake Via Nutritional Habits and Supplementation