Exposure to low -
oxygen air sends EPO levels soaring in normal mice, but these
conditions did not
induce a rise in the hormone in the animals without HIF - 1α, the researchers report in the 18 April issue of Cell.
Creating his own tools and conducting a series of surgical procedures on canine hearts, Thomas
induced a similar level of
oxygen deprivation in the dogs and, by correcting the abnormality, reversed their
condition.