Not exact matches
Hepatitis C Virus
Regulates Transforming Growth Factor [beta] 1 Production Through the Generation of Reactive
Oxygen Species in a Nuclear Factor [kappa] B - Dependent Manner.
Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive
oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that
regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.
We also don't want to down
regulate an immune response at times with the body is using reactive
oxygen species to say fight a pathogen.
Moreover, reactive nitrogen and
oxygen species (RNOS) are used extensively in cellular signalling, and cells adaptively
regulate endogenous antioxidants on short time scales to respond to deletorious spikes of RNOS faster than we could ever achieve with dietary antioxidants.
But pollution also covers hundreds of chemicals which are fine or even beneficial at low levels but which if released in large quantities or in problematic circumstances cause «harm» — like phosphorus (grows your veges but also leads to toxic cyanobacterial blooms which kill cattle), nitrogen (grows crops kills many native
species of plants and promotes weed growth costing farmers), copper (used as an
oxygen carrier by gastropods but in high concentrations kills the life in sediments which feed fish), hormones like oestrogen (essential for
regulating bodies but in high concentrations confuse reproductive cycles especially with marine life) or maybe molasses from a sugar mill (good for rum but when dumped into east coast estuaries used to cause
oxygen sag in estuaries leading to massive fish kills).